20 Result(s)
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Article
CREB1 Silencing Protects Against Inflammatory Response in Rats with Deep Vein Thrombosis Through Reducing RPL9 Expression and Blocking NF-κB Signaling
Apoptosis and inflammation of vascular endothelial cells (VECs) are the most important causes of deep vein thrombosis (DVT). cAMP response element binding protein 1 (CREB1) encodes a transcription factor that ...
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Article
Correlative Mn-Co catalyst excels Pt in oxygen reduction reaction of quasi-solid-state zinc-air batteries
Zn-air batteries (ZABs) as a class of promising energy storage setups are generally powered by efficient and robust catalysts at the oxygen-involving cathode. Although the existing non-noble catalysts have out...
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Open AccessImpact of preoperative transcatheter arterial chemoembolization (TACE) on postoperative long-term survival in patients with nonsmall hepatocellular carcinoma: a propensity score matching analysis
The purpose of this propensity score matching (PSM) analysis was to compare the effects of preoperative transcatheter arterial chemoembolization (TACE) and non-TACE on the long-term survival of patients who un...
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Article
Open AccessContrast media extravasation injury: a prospective observational cohort study
To identify the risk factors for moderate and severe contrast media extravasation and provide effective guidance to reduce the degree of extravasation injuries.
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Article
Artificial intelligence-assisted colorimetry for urine glucose detection towards enhanced sensitivity, accuracy, resolution, and anti-illuminating capability
Colorimetry often suffers from deficiency in quantitative determination, susceptibility to ambient illuminance, and low sensitivity and visual resolution to tiny color changes. To offset these deficiencies, we...
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FOXO1-miR-506 axis promotes chemosensitivity to temozolomide and suppresses invasiveness in glioblastoma through a feedback loop of FOXO1/miR-506/ETS1/FOXO1
To explore the role of forkhead box protein O1 (FOXO1) in the progression of glioblastoma multiforme (GBM) and related drug resistance, we deciphered the roles of FOXO1 and miR-506 in proliferation, apoptosis,...
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Genomic profiling informs diagnoses and treatment in vascular anomalies
Vascular anomalies are malformations or tumors of the blood or lymphatic vasculature and can be life-threatening. Although molecularly targeted therapies can be life-saving, identification of the molecular eti...
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Article
Open AccessApoE4 associated with severe COVID-19 outcomes via downregulation of ACE2 and imbalanced RAS pathway
Recent numerous epidemiology and clinical association studies reported that ApoE polymorphism might be associated with the risk and severity of coronavirus disease 2019 (COVID-19), and yielded inconsistent result...
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Open AccessTie1 contributes to the development of ovarian hyperstimulation syndrome under the regulation of EGR1 in granulosa cells
The expression of tyrosine kinase with immunoglobulin-like and epidermal growth factor-like domains 1 (Tie1), a transmembrane protein expressed almost exclusively by endothelial cells, has been reported in gra...
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Article
Prediction of drug efficacy from transcriptional profiles with deep learning
Drug discovery focused on target proteins has been a successful strategy, but many diseases and biological processes lack obvious targets to enable such approaches. Here, to overcome this challenge, we describ...
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Open AccessTargeting of IL-10R on acute myeloid leukemia blasts with chimeric antigen receptor-expressing T cells
Acute myeloid leukemia (AML) is a biologically and clinically heterogeneous disease with a dismal prognosis and limited treatment options. Chimeric antigen receptor (CAR) T cells have achieved unprecedented cl...
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Article
Comparison of Metabolic Profiling of Arabidopsis Inflorescences Between Landsberg erecta and Columbia, and Meiosis-Defective Mutants by 1H-NMR Spectroscopy
With the rapid development of omics technologies during the last several decades, genomics, transcriptomics, and proteomics have been extensively used to characterize gene or protein functions in many organism...
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Article
Multiple Non-coding ANRIL Transcripts Are Associated with Risk of Coronary Artery Disease: a Promising Circulating Biomarker
Multiple ANRIL transcriptional isoforms, such as lncANRIL and circANRIL have been identified. We sought to explore their diagnostic value in patients with coronary artery disease (CAD). First, we selected six ...
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Article
Open AccessObesity is associated with increased severity of disease in COVID-19 pneumonia: a systematic review and meta-analysis
Obesity has been widely reported to be associated with the disease progression of coronavirus disease 2019 (COVID-19); however, some studies have reported different findings. We conducted a systematic review a...
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Evaluation of a cell model expressing βKlotho for screening FGF21 analogues
βKlotho as the major role is a necessary auxiliary protein when fibroblast growth factor 21 (FGF21) binds FGF21 receptors (FGFR) for activating intracellular signaling pathways that ultimately generate biologi...
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Article
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases
A meta-analysis across ten pediatric autoimmune diseases reveals shared genetic architecture and novel susceptibility loci.
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Article
Open AccessLeptomeningeal metastasis from hepatocellular carcinoma with other unusual metastases: a case report
Leptomeningeal metastasis, which results from metastasis of tumors to the arachnoid and pia mater, can lead to the dissemination of tumor cells throughout the subarachnoid space via the cerebral spinal fluid, ...
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Article
A Label-Free Oligonucleotide Based Thioflavin-T Fluorescent Switch for Ag+ Detection with low Background Emission
A novel fluorescent Ag+ sensor was developed based on the label-free silver (I) specific oligonucleotide (SSO) and Thioflavine T (ThT) monomer-excimer switch. C-rich SSO which contain C-C mismatched base pairs ca...
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Article
Photobleaching-Based Quantitative Analysis of Fluorescence Resonance Energy Transfer inside Single Living Cell
The current advances of fluorescence microscopy and new fluorescent probes make fluorescence resonance energy transfer (FRET) a powerful technique for studying protein-protein interactions inside living cells....
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Article
Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes
The latency of human immunodeficiency virus type 1 (HIV-1) in resting primary CD4+ T cells is the major barrier for the eradication of the virus in patients on suppressive highly active antiretroviral therapy (HA...
