33 Result(s)
within
Science, Humanities and Social Sciences, multidisciplinary
**angxi Wang
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Article
Open AccessQuantitative analysis and stochastic modeling of osteophyte formation and growth process on human vertebrae based on radiographs: a follow-up study
Osteophytes are frequently observed in elderly people and most commonly appear at the anterior edge of the cervical and lumbar vertebrae body. The anterior osteophytes keep develo** and will lead to neck/bac...
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Article
Open AccessNon-linear relationship between pulse pressure and the risk of prediabetes: a 5-year cohort study in Chinese adults
Previous research has established a strong link between pulse pressure (PP) and diabetes, but there is limited investigation into the connection between PP and prediabetes. This study aims to explore the poten...
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Article
Open AccessStructural and functional insights into the lipid regulation of human anion exchanger 2
Anion exchanger 2 (AE2) is an electroneutral Na+-independent Cl-/HCO3- exchanger belongs to the SLC4 transporter family. The widely expressed AE2 participates in a variety of physiological processes, including tr...
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Article
Open AccessA Machine Learning-Driven Virtual Biopsy System For Kidney Transplant Patients
In kidney transplantation, day-zero biopsies are used to assess organ quality and discriminate between donor-inherited lesions and those acquired post-transplantation. However, many centers do not perform such...
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Article
Open AccessClose relatives of MERS-CoV in bats use ACE2 as their functional receptors
Middle East respiratory syndrome coronavirus (MERS-CoV) and several bat coronaviruses use dipeptidyl peptidase-4 (DPP4) as an entry receptor1–4. However, the receptor for NeoCoV—the closest known MERS-CoV relativ...
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Article
Open AccessBA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages BA.2.12.1, BA.4 and BA.5 exhibit higher transmissibility than the BA.2 lineage1. The receptor binding and immune-evasion capability...
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Article
Open AccessMemory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants
Omicron (B.1.1.529), the most heavily mutated SARS-CoV-2 variant so far, is highly resistant to neutralizing antibodies, raising concerns about the effectiveness of antibody therapies and vaccines1,2. Here we exa...
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Article
Open AccessOmicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies
The SARS-CoV-2 B.1.1.529 (Omicron) variant contains 15 mutations of the receptor-binding domain (RBD). How Omicron evades RBD-targeted neutralizing antibodies requires immediate investigation. Here we use high...
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Article
Open AccessCharacterization and structural basis of a lethal mouse-adapted SARS-CoV-2
There is an urgent need for animal models to study SARS-CoV-2 pathogenicity. Here, we generate and characterize a novel mouse-adapted SARS-CoV-2 strain, MASCp36, that causes severe respiratory symptoms, and mo...
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Article
Open AccessThe architecture of the SARS-CoV-2 RNA genome inside virion
SARS-CoV-2 carries the largest single-stranded RNA genome and is the causal pathogen of the ongoing COVID-19 pandemic. How the SARS-CoV-2 RNA genome is folded in the virion remains unknown. To fill the knowled...
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Article
Open AccessConserved regulatory logic at accessible and inaccessible chromatin during the acute inflammatory response in mammals
The regulatory elements controlling gene expression during acute inflammation are not fully elucidated. Here we report the identification of a set of NF-κB-bound elements and common chromatin landscapes underl...
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Article
Open AccessSerotype specific epitopes identified by neutralizing antibodies underpin immunogenic differences in Enterovirus B
Echovirus 30 (E30), a serotype of Enterovirus B (EV-B), recently emerged as a major causative agent of aseptic meningitis worldwide. E30 is particularly devastating in the neonatal population and currently no vac...
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Article
Open AccessStructures of Echovirus 30 in complex with its receptors inform a rational prediction for enterovirus receptor usage
Receptor usage that determines cell tropism and drives viral classification closely correlates with the virus structure. Enterovirus B (EV-B) consists of several subgroups according to receptor usage, among which...
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Article
Open AccessHand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10
Coxsackievirus A10 (CV-A10) is responsible for an escalating number of severe infections in children, but no prophylactics or therapeutics are currently available. KREMEN1 (KRM1) is the entry receptor for the ...
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Article
Open AccessAssembly of complex viruses exemplified by a halophilic euryarchaeal virus
Many of the largest known viruses belong to the PRD1-adeno structural lineage characterised by conserved pseudo-hexameric capsomers composed of three copies of a single major capsid protein (MCP). Here, by hig...
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Article
Open AccessClonal architectures predict clinical outcome in clear cell renal cell carcinoma
The genetic landscape of clear cell renal cell carcinoma (ccRCC) had been investigated extensively but its evolution patterns remained unclear. Here we analyze the clonal architectures of 473 patients from thr...
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Article
Open AccessWhole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer
Bladder cancer is one of the most common and highly vascularized cancers. To better understand its genomic structure and underlying etiology, we conduct whole-genome and targeted sequencing in urothelial bladd...
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Article
Open AccessStructures of Coxsackievirus A10 unveil the molecular mechanisms of receptor binding and viral uncoating
Coxsackievirus A10 (CVA10), a human type-A Enterovirus (HEV-A), can cause diseases ranging from hand-foot-and-mouth disease to polio-myelitis-like disease. CVA10, together with some other HEV-As, utilizing the mo...
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Article
Open AccessStructure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component
Herpes simplex viruses (HSVs) cause human oral and genital ulcer diseases. Patients with HSV-2 have a higher risk of acquiring a human immunodeficiency virus infection. HSV-2 is a member of the α-herpesvirinae su...
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Open AccessPushing the resolution limit by correcting the Ewald sphere effect in single-particle Cryo-EM reconstructions
The Ewald sphere effect is generally neglected when using the Central Projection Theorem for cryo electron microscopy single-particle reconstructions. This can reduce the resolution of a reconstruction. Here w...
