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Article
Pharmacokinetics of nirmatrelvir/ritonavir and the drug-drug interaction with calcineurin inhibitor in renal transplant recipients
To describe the pharmacokinetic (PK) characteristics of nirmatrelvir/ritonavir in renal transplant recipients and explore the potential factors that related to the PK variance of nirmatrelvir/ritonavir and its...
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Article
Open AccessA dual RNA-seq analyses revealed dynamic arms race during the invasion of walnut by Colletotrichum gloeosporioides
Walnut anthracnose caused by Colletotrichum gloeosporioides seriously endangers the yield and quality of walnut, and has now become a catastrophic disease in the walnut industry. Therefore, understanding both pat...
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Article
Selective Activation of G Protein–Coupled Estrogen Receptor 1 (GPER1) Reduces ER Stress and Pyroptosis via AMPK Signaling Pathway in Experimental Subarachnoid Hemorrhage
Neuroinflammation is a critical pathogenic event following hemorrhagic stroke. Endoplasmic reticulum (ER) stress–induced apoptosis and nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containin...
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Article
Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms
Smc5/6 is a member of the eukaryotic structural maintenance of chromosomes (SMC) family of complexes with important roles in genome maintenance and viral restriction. However, limited structural understanding ...
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Article
Interactive and discriminative analysis dictionary learning for image classification
Dictionary learning is widely utilized in pattern recognition, and analysis dictionary learning is a prevalent image classification method. However, its classification performance still has much room for impro...
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Article
Open AccessThe effect of retirement on physical and mental health in China: a nonparametric fuzzy regression discontinuity study
With the rapid aging of the domestic population, China has a strong incentive to increase the statutory retirement age. How retirement affects the health of the elderly is crucial to this policymaking. The hea...
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Article
Open AccessQuantitative analysis and stochastic modeling of osteophyte formation and growth process on human vertebrae based on radiographs: a follow-up study
Osteophytes are frequently observed in elderly people and most commonly appear at the anterior edge of the cervical and lumbar vertebrae body. The anterior osteophytes keep develo** and will lead to neck/bac...
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Article
Multi-view clustering via dual-norm and HSIC
Fully capturing valid complementary information in multi-view data enhances the connection between similar data points and weakens the correlation between different data point categories. In this paper, we pro...
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Article
Open AccessNon-linear relationship between pulse pressure and the risk of prediabetes: a 5-year cohort study in Chinese adults
Previous research has established a strong link between pulse pressure (PP) and diabetes, but there is limited investigation into the connection between PP and prediabetes. This study aims to explore the poten...
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Article
Open AccessStructural and functional insights into the lipid regulation of human anion exchanger 2
Anion exchanger 2 (AE2) is an electroneutral Na+-independent Cl-/HCO3- exchanger belongs to the SLC4 transporter family. The widely expressed AE2 participates in a variety of physiological processes, including tr...
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Article
Open AccessA Machine Learning-Driven Virtual Biopsy System For Kidney Transplant Patients
In kidney transplantation, day-zero biopsies are used to assess organ quality and discriminate between donor-inherited lesions and those acquired post-transplantation. However, many centers do not perform such...
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Article
One-pot synthesis of novel mesoporous FeOOH modified NaZrH(PO4)2·H2O for the enhanced removal of Co(II) from aqueous solution
One-pot synthesis of a novel mesoporous hydroxyl oxidize iron functional Na-zirconium phosphate (FeOOH-NaZrH(PO4)2·H2O) composites was firstly characterized and investigated its Co(II) adsorption from aqueous sol...
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Article
Open AccessAuthor Correction: A broader neutralizing antibody against all the current VOCs and VOIs targets unique epitope of SARS-CoV-2 RBD
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Article
Open AccessAuthor Correction: Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses
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Article
Low-rank tensor multi-view subspace clustering via cooperative regularization
In order to explore the importance of the hypergraph regularization and the Tikhonov regularization in multi-view clustering, this paper proposes a novel multi-view clustering model, termed as low-rank tensor ...
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Article
Open AccessAnomaly prediction of CT equipment based on IoMT data
Large-scale medical equipment, which is extensively implemented in medical services, is of vital importance for diagnosis but vulnerable to various anomalies and failures. Most hospitals that conduct regular m...
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Article
Open AccessHost susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses
The bat coronaviruses (CoV) BANAL-20-52 and BANAL-20-236 are two newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) closely related coronaviruses (SC2r-CoV) and the genome of BANAL-2...
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Article
Open AccessDecreased left heart flow in fetal lambs causes left heart hypoplasia and pro-fibrotic tissue remodeling
Low blood flow through the fetal left heart is often conjectured as an etiology for hypoplastic left heart syndrome (HLHS). To investigate if a decrease in left heart flow results in growth failure, we generat...
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Article
RENAL nephrometry scoring system in bilateral Wilms tumor: predictive application
This study aims to explore the application of RENAL nephrometry scoring system in bilateral Wilms tumor (BWT).
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Article
Open AccessCancer metabolites: promising biomarkers for cancer liquid biopsy
Cancer exerts a multitude of effects on metabolism, including the reprogramming of cellular metabolic pathways and alterations in metabolites that facilitate inappropriate proliferation of cancer cells and ada...
