16 Result(s)
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Open AccessA Ka-band one-dimensional beam scanning leaky-wave antenna based on liquid crystal
Fixed frequency beam-scanning leaky-wave antennas have been a focus of attention for many scholars in recent years, and numerous related results have been obtained. However, these antennas suffer from several ...
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Open AccessTwo chromosome-level genomes of Smittia aterrima and Smittia pratorum (Diptera, Chironomidae)
Chironomids are one of the most abundant aquatic insects and are widely distributed in various biological communities. However, the lack of high-quality genomes has hindered our ability to study the evolution ...
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Open AccessMulti-domain-fusion deep learning for automatic modulation recognition in spatial cognitive radio
Automatic modulation recognition (AMR) is a critical technology in spatial cognitive radio (SCR), and building high-performance AMR model can achieve high classification accuracy of signals. AMR is a classific...
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Open AccessComparative mitogenome analyses of twelve non-biting flies and provide insights into the phylogeny of Chironomidae (Diptera: Culicomorpha)
The family Chironomidae is represented by seven subfamilies in China, among which Chironominae and Orthocladiinae are the most diverse. To gain a better understanding of the architecture and evolution of the m...
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Open AccessCombPDX: a unified statistical framework for evaluating drug synergism in patient-derived xenografts
Anticancer combination therapy has been developed to increase efficacy by enhancing synergy. Patient-derived xenografts (PDXs) have emerged as reliable preclinical models to develop effective treatments in tra...
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Open AccessCombined MEK/MDM2 inhibition demonstrates antitumor efficacy in TP53 wild-type thyroid and colorectal cancers with MAPK alterations
Most tumors with activating MAPK (mitogen-activated protein kinase) pathway alterations respond poorly to MEK inhibitors alone. Here, we evaluated combination therapy with MEK inhibitor selumetinib and MDM2 in...
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Open AccessAuthor Correction: Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment
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Open AccessStructure-based classification predicts drug response in EGFR-mutant NSCLC
Epidermal growth factor receptor (EGFR) mutations typically occur in exons 18–21 and are established driver mutations in non-small cell lung cancer (NSCLC)1–3. Targeted therapies are approved for patients with ‘c...
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Open AccessComprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment
Development of candidate cancer treatments is a resource-intensive process, with the research community continuing to investigate options beyond static genomic characterization. Toward this goal, we have estab...
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Author Correction: DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
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Article
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
Ferroptosis, a form of regulated cell death that is induced by excessive lipid peroxidation, is a key tumour suppression mechanism1–4. Glutathione peroxidase 4 (GPX4)5,6 and ferroptosis suppressor protein 1 (FSP1...
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Open AccessmTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
Glutathione peroxidase 4 (GPX4) utilizes glutathione (GSH) to detoxify lipid peroxidation and plays an essential role in inhibiting ferroptosis. As a selenoprotein, GPX4 protein synthesis is highly inefficient...
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Elevated NSD3 histone methylation activity drives squamous cell lung cancer
Amplification of chromosomal region 8p11–12 is a common genetic alteration that has been implicated in the aetiology of lung squamous cell carcinoma (LUSC)1–3. The FGFR1 gene is the main candidate driver of tumor...
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Open AccessPrimary-tiller panicle number is critical to achieving high grain yields in machine-transplanted hybrid rice
The development of machine-transplanted hybrid rice is a feasible approach to meet the needs of both high grain yield and high labor efficiency in China, but limited information is available on the critical pl...
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Open AccessEvolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa
Pseudomonas aeruginosa colonises the upper airway of cystic fibrosis (CF) patients, providing a reservoir of host-adapted genotypes that subsequently establish chronic lung infection. We previously experimentally...
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Open AccessTUSC2(FUS1)-erlotinib Induced Vulnerabilities in Epidermal Growth Factor Receptor(EGFR) Wildtype Non-small Cell Lung Cancer(NSCLC) Targeted by the Repurposed Drug Auranofin
Expression of the TUSC2/FUS1 tumor suppressor gene in TUSC2 deficient EGFR wildtype lung cancer cells increased sensitivity to erlotinib. Microarray mRNA expression analysis of TUSC2 inducible lung cancer cell...
