7 Result(s)
within
**angliang Fang
Life Sciences
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Article
Open AccessAuthor Correction: 3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib
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Open Access3-Phosphoinositide-dependent kinase 1 drives acquired resistance to osimertinib
Osimertinib sensitive and resistant NSCLC NCI-H1975 clones are used to model osimertinib acquired resistance in humanized and non-humanized mice and delineate potential resistance mechanisms. No new EGFR mutat...
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Open AccessThe MYEOV-MYC association promotes oncogenic miR-17/93-5p expression in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy worldwide. As metastasis and malignant progression are primarily responsible for the poor clinical outcomes of PDAC, identifying key genes ...
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Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer
SLC7A11-mediated cystine uptake is critical for maintaining redox balance and cell survival. Here we show that this comes at a significant cost for cancer cells with high levels of SLC7A11. Actively importing ...
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The Inhibitory Effects of Nitrogen Deposition on Asymbiotic Nitrogen Fixation are Divergent Between a Tropical and a Temperate Forest
Asymbiotic nitrogen (N) fixation (ANF) is an important source of N in pristine forests and is predicted to decrease with N deposition. Previous studies revealing N fixation in response to N deposition have mos...
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Systems biology guided by XCMS Online metabolomics
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Vegetation productivity consequences of human settlement growth in the eastern United States
In this study, we investigated the impact of human settlement growth on vegetation carbon uptake in the eastern United States between 1992/1993 and 2001. Human settlement growth was measured by changes in the ...
