22 Result(s)

Article

CYLD induces high oxidative stress and DNA damage through class I HDACs to promote radiosensitivity in nasopharyngeal carcinoma

Abnormal expression of Cylindromatosis (CYLD), a tumor suppressor molecule, plays an important role in tumor development and treatment. In this work, we found that CYLD binds to class I histone deacetylases (H...

Yueshuo Li, Chenxing Yang, Longlong **e, Feng Shi, Min Tang… in Cell Death & Disease (2024)

Article

Anoikis resistance and immune escape mediated by Epstein-Barr virus-encoded latent membrane protein 1-induced stabilization of PGC-1α promotes invasion and metastasis of nasopharyngeal carcinoma

Epstein-Barr virus (EBV) is the first discovered human tumor virus that is associated with a variety of malignancies of both lymphoid and epithelial origin including nasopharyngeal carcinoma (NPC). The EBV-enc...

Chaoliang Liao, Min Li, Xue Chen… in Journal of Experimental & Clinical Cancer … (2023)

Article

Protective role of nitric oxide donors on endothelium in ischemia-reperfusion injury: a meta-analysis of randomized controlled trials

Decreased bioavailability of nitric oxide (NO) under hypoxic conditions can lead to endothelial dysfunction. NO supplementation may protect endothelial function in ischemia-reperfusion (IR) injury. Therefore, ...

Chaoxun Dou, Xue Han, Hanbin **e, Haofeng Liao, Xue **ao, Ziyan Huang… in BMC Anesthesiology (2023)

Article

Correction: Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance

Longlong **e, Feng Shi, Yueshuo Li, We Li… in Signal Transduction and Targeted Therapy (2022)

Article

DHRS2 inhibits cell growth and metastasis in ovarian cancer by downregulation of CHKα to disrupt choline metabolism

The short-chain dehydrogenase/reductase (SDR) superfamily has essential roles in lipid metabolism and redox sensing. In recent years, accumulating evidence highlights the emerging association between SDR famil...

Zhenzhen Li, Yue Tan, **ang Li, **g Quan, Ann M. Bode, Ya Cao… in Cell Death & Disease (2022)

Article

CPT1A-mediated fatty acid oxidation promotes cell proliferation via nucleoside metabolism in nasopharyngeal carcinoma

As the first rate-limiting enzyme in fatty acid oxidation (FAO), CPT1 plays a significant role in metabolic adaptation in cancer pathogenesis. FAO provides an alternative energy supply for cancer cells and is ...

Min Tang, **n Dong, Lanbo **ao, Zheqiong Tan, **angjian Luo… in Cell Death & Disease (2022)

Article

Stabilization of p18 by deubiquitylase CYLD is pivotal for cell cycle progression and viral replication

p18 is a key negative regulator of cell cycle progression and mediates cell cycle arrest at the G1/S phase. Ubiquitination is the prime mechanism in regulating p18 protein abundance. However, so far no post- t...

Yueshuo Li, Feng Shi, Jianmin Hu, Longlong **e, Lin Zhao… in npj Precision Oncology (2021)

Article

Targeting the signaling in Epstein–Barr virus-associated diseases: mechanism, regulation, and clinical study

Epstein–Barr virus-associated diseases are important global health concerns. As a group I carcinogen, EBV accounts for 1.5% of human malignances, including both epithelial- and lymphatic-originated tumors. Mor...

Ya Cao, Longlong **e, Feng Shi, Min Tang… in Signal Transduction and Targeted Therapy (2021)

Article

Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistance

Latent membrane protein 1 (LMP1) is a major Epstein–Barr virus (EBV)-encoded oncoprotein involved in latency infection that regulates mitochondrial functions to facilitate cell survival. Recently, mitochondria...

Longlong **e, Feng Shi, Yueshuo Li, We Li… in Signal Transduction and Targeted Therapy (2020)

Article

Inhibition of gap junction composed of Cx43 prevents against acute kidney injury following liver transplantation

Postoperative acute kidney injury (AKI) is a severe complication after liver transplantation (LT). Its deterioration and magnification lead to the increase in mortality. Connexin43 (Cx43) mediates direct trans...

Dongdong Yuan, **aoyun Li, Chenfang Luo, **anlong Li, Nan Cheng… in Cell Death & Disease (2019)

Article

DHRS2 mediates cell growth inhibition induced by Trichothecin in nasopharyngeal carcinoma

Cancer is fundamentally a deregulation of cell growth and proliferation. Cancer cells often have perturbed metabolism that leads to the alteration of metabolic intermediates. Dehydrogenase/reductase member 2 (...

**angjian Luo, Namei Li, Xu Zhao… in Journal of Experimental & Clinical Cancer … (2019)

Article

The implications of signaling lipids in cancer metastasis

Metastasis is the most malignant stage of cancer. Lipid metabolic abnormalities are now increasingly recognized as characteristics of cancer cells. The accumulation of certain lipid species, such as signaling ...

**angjian Luo, Xu Zhao, Can Cheng, Namei Li, Ying Liu… in Experimental & Molecular Medicine (2018)

Article

DNMT1 mediates metabolic reprogramming induced by Epstein–Barr virus latent membrane protein 1 and reversed by grifolin in nasopharyngeal carcinoma

Cancer cells frequently adapt fundamentally altered metabolism to support tumorigenicity and malignancy. Epigenetic and metabolic networks are closely interactive, in which DNA methyltransferases (DNMTs) play ...

**angjian Luo, Li** Hong, Can Cheng, Namei Li, Xu Zhao, Feng Shi… in Cell Death & Disease (2018)

Article

Epstein-Barr virus encoded latent membrane protein 1 suppresses necroptosis through targeting RIPK1/3 ubiquitination

Necroptosis is an alternative programmed cell death pathway that is unleashed in the absence of apoptosis and mediated by signaling complexes containing receptor-interating protein kinase 1 (RIPK1) and RIPK3. ...

**aolan Liu, Yueshuo Li, Songling Peng, **nfang Yu, Wei Li… in Cell Death & Disease (2018)

Article

Emerging roles of lipid metabolism in cancer metastasis

Cancer cells frequently display fundamentally altered cellular metabolism, which provides the biochemical foundation and directly contributes to tumorigenicity and malignancy. Rewiring of metabolic programmes,...

**angjian Luo, Can Cheng, Zheqiong Tan, Namei Li, Min Tang, Lifang Yang… in Molecular Cancer (2017)

Article

Propofol attenuated liver transplantation-induced acute lung injury via connexin43 gap junction inhibition

Postoperative acute lung injury (ALI) is a severe complication after liver transplantation, which influences patient survival rate obviously. However, its mechanisms are unclear and effective therapies are sti...

Dongdong Yuan, Guangjie Su, Yue Liu, **n** Chi… in Journal of Translational Medicine (2016)

Article

Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells

Neural progenitor (NP) cells are the multipotent cells that produce neurons and glia in the central nervous system. Compounds regulating their proliferation are key to both understanding brain development and ...

Ji heon Rhim, **angjian Luo, Dongbing Gao, **aoyun Xu, Tieling Zhou… in Scientific Reports (2016)