66 Result(s)

Article

Correction: LncRNA SNHG1 and RNA binding protein hnRNPL form a complex and coregulate CDH1 to boost the growth and metastasis of prostate cancer

**ao Tan, Wen-bin Chen, Dao-jun Lv, Tao-wei Yang, Kai-hui Wu… in Cell Death & Disease (2024)

Article

Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy

Ketogenic diet (KD) alleviates refractory epilepsy and reduces seizures in children. However, the metabolic/cell biologic mechanisms by which the KD exerts its antiepileptic efficacy remain elusive. Herein, we...

Ya-Nan Qiao, Lei Li, Song-Hua Hu, Yuan-**n Yang, Zhen-Zhen Ma, Lin Huang… in Cell Discovery (2024)

Article

Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling

Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia, and recent epidemiological studies suggested type 2 diabetes mellitus (T2DM) is an independent risk factor for the development of AF...

Zhi-**ng Wei, **ng-**ng Cai, Yu-Dong Fei, Qian Wang… in Cellular and Molecular Life Sciences (2024)

Article

Silencing circSERPINE2 restrains mesenchymal stem cell senescence via the YBX3/PCNA/p21 axis

Increasing evidence indicates that circular RNAs (circRNAs) accumulate in aging tissues and nonproliferating cells due to their high stability. However, whether upregulation of circRNA expression mediates stem...

Fenglei Chen, Shan Wang, Chenying Zeng, Su’an Tang… in Cellular and Molecular Life Sciences (2023)

Article

Macrophage-mediated trogocytosis contributes to destroying human schistosomes in a non-susceptible rodent host, Microtus fortis

Schistosoma parasites, causing schistosomiasis, exhibit typical host specificity in host preference. Many mammals, including humans, are susceptible to infection, while the widely distributed rodent, Microtus for...

Jia Shen, Siyu Zhao, Mei Peng, Yanguo Li, Lichao Zhang, ** Li… in Cell Discovery (2023)

Article

Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1

Tumor-derived exosomes and their contents promote cancer metastasis. Phosphoglycerate mutase 1 (PGAM1) is involved in various cancer-related processes. Nevertheless, the underlying mechanism of exosomal PGAM1 ...

Jun-qi Luo, Tao-wei Yang, Jun Wu, Hou-hua Lai, Li-bin Zou… in Cell Death & Disease (2023)

Article

GATA zinc finger protein p66β promotes breast cancer cell migration by acting as a co-activator of Snail

The transcriptional repressor Snail induces EMT during embryonic development and tumor metastasis. Growing evidence indicates that Snail functions as a trans-activator to induce gene expression; however, the u...

**uqun Zou, Li Ma, Yihong Zhang, Qun Zhang, Chu Xu, Dan Zhang… in Cell Death & Disease (2023)

Article

A PPIX-binding probe facilitates discovery of PPIX-induced cell death modulation by peroxiredoxin

While heme synthesis requires the formation of a potentially lethal intermediate, protoporphyrin IX (PPIX), surprisingly little is known about the mechanism of its toxicity, aside from its phototoxicity. The c...

John Lynch, Yao Wang, Yuxin Li, Kanisha Kavdia, Yu Fukuda… in Communications Biology (2023)

Article

A live-cell image-based machine learning strategy for reducing variability in PSC differentiation systems

The differentiation of pluripotent stem cells (PSCs) into diverse functional cell types provides a promising solution to support drug discovery, disease modeling, and regenerative medicine. However, functional...

**aochun Yang, Daichao Chen, Qiushi Sun, Yao Wang, Yu **a, **yu Yang… in Cell Discovery (2023)

Article

Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis

The discovery and characterization of antigen-specific CD8⁺ T cell clonotypes typically involves the labor-intensive synthesis and construction of peptide-MHC tetramers. We adapt single-chain trimer (SCT) technol...

William Chour, Jongchan Choi, **gyi **e, Mary E. Chaffee… in Communications Biology (2023)

Article

The mitochondrial protein TIMM44 is required for angiogenesis in vitro and in vivo

The mitochondrial integrity and function in endothelial cells are essential for angiogenesis. TIMM44 (translocase of inner mitochondrial membrane 44) is essential for integrity and function of mitochondria. He...

Zhou-rui Ma, Hong-Peng Li, Shi-zhong Cai, Sheng-Yang Du, **a Chen… in Cell Death & Disease (2023)

Article

Biomarkers of aging

Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although ...

Hainan Bao, Jiani Cao, Mengting Chen, Min Chen, Wei Chen… in Science China Life Sciences (2023)

Article

TPX2 enhances the transcription factor activation of PXR and enhances the resistance of hepatocellular carcinoma cells to antitumor drugs

The pregnane X receptor (PXR) is an important regulator of hepatocellular carcinoma cellular resistance to antitumor drugs. Activation of PXR was modulated by the co-regulators. The target protein for the Xeno...

Hongbo Wang, Fang Chu, **ao-feng Zhang, Peng Zhang, Li-xin Li… in Cell Death & Disease (2023)

Article

Uniform thin ice on ultraflat graphene for high-resolution cryo-EM

Cryo-electron microscopy (cryo-EM) visualizes the atomic structure of macromolecules that are embedded in vitrified thin ice at their close-to-native state. However, the homogeneity of ice thickness, a key fac...

Liming Zheng, Nan Liu, **aoyin Gao, Wenqing Zhu, Kun Liu, Cang Wu… in Nature Methods (2023)

Article

The landscape of aging

Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death. It is a major risk factor for chronic ...

Yusheng Cai, Wei Song, Jiaming Li, Ying **g, Chuqian Liang… in Science China Life Sciences (2022)