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Article
The hard X-ray nanoprobe beamline at the SSRF
The hard X-ray nanoprobe beamline BL13U is a phase-II beamline project at the Shanghai Synchrotron Radiation Facility. The beamline aims to enable comprehensive experiments at high spatial resolutions ranging ...
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Article
Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor
Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, ...
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Article
Cell-Free Supernatant of Bacillus subtilis G2B9-Q Improves Intestinal Health and Modulates Immune Response to Promote Mouse Recovery in Clostridium perfringens Infection
Clostridium perfringens is one of the critical causative agents causing diarrhea in piglets, with significant economic losses to the pig industry. Under normal gut microbiota homeostasis and well-managed barns, d...
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Article
Influence of pier height on the safety of trains running on high-speed railway bridges during earthquakes
Sudden earthquakes pose a threat to the running safety of trains on high-speed railway bridges, and the stiffness of piers is one of the factors affecting the dynamic response of train-track-bridge system. In ...
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Article
Open AccessSusceptibility gene identification and risk evaluation model construction by transcriptome-wide association analysis for salt sensitivity of blood pressure
Salt sensitivity of blood pressure (SSBP) is an intermediate phenotype of hypertension and is a predictor of long-term cardiovascular events and death. However, the genetic structures of SSBP are uncertain, an...
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Article
A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
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Article
Seismic performance of a new type of prefabricated bridge pier with cast-in-place UHPC jacketing
Accelerated bridge construction (ABC) is prevalent all over the world attributable to its technical advantages including the higher construction efficiency, less traffic disruption, and higher construction qua...
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Article
Gas-Bearing Reservoir Prediction Using k-nearest neighbor Based on Nonlinear Directional Dimension Reduction
In this study, a k-nearest neighbor (kNN) method based on nonlinear directional dimension reduction is applied to gas-bearing reservoir prediction. The kNN method can select the most relevant training samples ...
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Article
Multitask Weighted Adaptive Prestack Seismic Inversion
Traditional deep learning methods pursue complex and single network architectures without considering the petrophysical relationship between different elastic parameters. The mathematical and statistical signi...
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Article
Comprehensive Glycosylation Characterization of Recombinant Human Erythropoietin by Electron-Activated Dissociation Mass Spectrometry
Recombinant human erythropoietin (rhEPO) is a glycoprotein that acts as the main hormone involved in regulating red blood cell production to treat anemia caused by chronic kidney disease or chemotherapy, which...
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Article
Desloratadine alleviates ALS-like pathology in hSOD1G93A mice via targeting 5HTR2A on activated spinal astrocytes
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with progressive loss of motor neurons in the spinal cord, cerebral cortex and brain stem. ALS is characterized by gradual muscle atroph...
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Article
Open AccessPhotocatalytic Z/E isomerization unlocking the stereodivergent construction of axially chiral alkene frameworks
The past century has witnessed a large number of reports on the Z/E isomerization of alkenes. However, the vast majority of them are still limited to the isomerization of di- and tri-substituted alkenes. The ster...
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Article
Open AccessHigh-throughput sequencing-based analysis of the composition and diversity of the endophyte community in roots of Stellera chamaejasme
Stellera chamaejasme (S. chamaejasme) is an important medicinal plant with heat-clearing, detoxifying, swelling and anti-inflammatory effects. At the same time, it is also one of the iconic plants of natural gras...
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Article
Open AccessDeficiency of the HGF/Met pathway leads to thyroid dysgenesis by impeding late thyroid expansion
The mechanisms of bifurcation, a key step in thyroid development, are largely unknown. Here we find three zebrafish lines from a forward genetic screening with similar thyroid dysgenesis phenotypes and identif...
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Article
Environmental exposure to per- and polyfluoroalkyl substances mixture and asthma in adolescents
Previous epidemiological studies about the relationship between per- and polyfluoroalkyl substances (PFAS) concentrations and adolescent asthma have typically examined single PFAS, without considering the mixt...
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Article
Gastric intestinal metaplasia: progress and remaining challenges
Most gastric cancers arise in the setting of chronic inflammation which alters gland organization, such that acid-pum** parietal cells are lost, and remaining cells undergo metaplastic change in differentiat...
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Article
Vanishing viscosity limit to the planar rarefaction wave with vacuum for 3-D full compressible Navier–Stokes equations with temperature-dependent transport coefficients
In this paper, we construct a family of global-in-time solutions of the 3-D full compressible Navier–Stokes (N-S) equations with temperature-dependent transport coefficients (including viscosity and heat-condu...
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Article
The efficacy and safety of PD-1 inhibitor combined with TACE in the first-line treatment of unresectable hepatocellular carcinoma
The application of immune checkpoint inhibitors (ICIs) has changed the treatment of advanced hepatocellular carcinoma. Transcatheter arterial chemoembolization (TACE) is a first-line treatment for intermediate...
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Article
Open AccessPan-cancer analysis of NUP155 and validation of its role in breast cancer cell proliferation, migration, and apoptosis
NUP155 is reported to be correlated with tumor development. However, the role of NUP155 in tumor physiology and the tumor immune microenvironment (TIME) has not been previously examined. This study comprehensivel...
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Article
A seismic response prediction method based on a self-optimized Bayesian Bi-LSTM mixed network for high-speed railway track-bridge system
The construction of China’s high-speed railway (HSR) network has reached earthquake-prone regions, necessitating a timely and accurate post-disaster quick prediction approach to ensure the safety of the HSR sy...
