4,045 Result(s)
within
**ang-Lin Liu
-
Article
Raddeanin A Protects the BRB Through Inhibiting Inflammation and Apoptosis in the Retina of Alzheimer’s Disease
Neuroinflammation and endothelial cell apoptosis are prominent features of blood–brain barrier (BBB) disruption, which have been described in Alzheimer’s disease (AD) and can predict cognitive decline. Recent ...
-
Article
Open AccessAn 18-gene signature of recurrence-associated endothelial cells predicts tumor progression and castration resistance in prostate cancer
The prognostic and therapeutic implications of endothelial cells (ECs) heterogeneity in prostate cancer (PCa) are poorly understood.
-
Article
Open AccessNeutrophil-derived migrasomes are an essential part of the coagulation system
Migrasomes are organelles that are generated by migrating cells. Here we report the key role of neutrophil-derived migrasomes in haemostasis. We found that a large number of neutrophil-derived migrasomes exist...
-
Article
Open AccessSafety of embryo cryopreservation: insights from mid-term placental transcriptional changes
In recent years, with benefits from the continuous improvement of clinical technology and the advantage of fertility preservation, the application of embryo cryopreservation has been growing rapidly worldwide....
-
Article
Open AccessSynthetic macrolides overcoming MLSBK-resistant pathogens
Conventional macrolide-lincosamide-streptogramin B-ketolide (MLSBK) antibiotics are unable to counter the growing challenge of antibiotic resistance that is conferred by the constitutive methylation of rRNA base ...
-
Article
Open AccessCPEB2-activated axonal translation of VGLUT2 mRNA promotes glutamatergic transmission and presynaptic plasticity
Local translation at synapses is important for rapidly remodeling the synaptic proteome to sustain long-term plasticity and memory. While the regulatory mechanisms underlying memory-associated local translatio...
-
Article
Cobalt selenide confined in nitrogen-doped carbon skeleton as high-rated capability anode for sodium-ion batteries
硒化钴 (CoSe2) 因其高氧化还原反应活性和理论容量引起研究者广泛关注。然而, 其反应过程中较大的体积效应导致结构不稳定, 循环性能较差。本研究以采用溶剂热法合成的Co-沸石咪唑酯骨架为前驱体, 经过硒化处理得到CoSe2纳米颗粒。而沸石咪唑酯骨架在高温煅烧过程中原位转化为氮掺杂的碳层, 可以在充放电过程中起到导电和维持结构稳定性的作用。所得到的氮掺杂的碳骨架支撑的CoSe2(CoSe2@NC) 复合材料在0.2 A...
-
Article
Remote site-selective arene C–H functionalization enabled by N-heterocyclic carbene organocatalysis
Catalytic site-selective functionalization of distal C–H bonds represents a formidable challenge in organic synthesis. Particularly, the precise functionalization of distal aromatic C(sp2)–H bonds remains largely...
-
Article
Open AccessEpidemiological trends of subarachnoid hemorrhage at global, regional, and national level: a trend analysis study from 1990 to 2021
Subarachnoid hemorrhage (SAH) is a subtype of hemorrhagic stroke characterized by high mortality and low rates of full recovery. This study aimed to investigate the epidemiological characteristics of SAH betwe...
-
Article
Stable generation of Core-Shell droplets in Coaxial Electrohydrodynamic Printing by Numerical Simulation and Jet Mode Recognition
Core-shell droplets exhibit advantageous physical and chemical properties attributed to their unique structural composition, thereby presenting broader prospects for application in diverse fields including bio...
-
Article
Phylogenomics, divergence times and notes of orders in Basidiomycota
Basidiomycota is one of the major phyla in the fungal tree of life. The outline of Basidiomycota provides essential taxonomic information for researchers and workers in mycology. In this study, we present a ti...
-
Article
Open AccessPartitioning and aggregating cross-tissue and tissue-specific genetic effects to identify gene-trait associations
TWAS have shown great promise in extending GWAS loci to a functional understanding of disease mechanisms. In an effort to fully unleash the TWAS and GWAS information, we propose MTWAS, a statistical framework ...
-
Article
Towards long-life 500 Wh kg−1 lithium metal pouch cells via compact ion-pair aggregate electrolytes
The development of practical lithium metal cells is plagued by their limited lifespan, primarily due to the poor interfacial stability of the electrolytes. Here we present a compact ion-pair aggregate (CIPA) e...
-
Article
Open AccessReformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation
Fully targeted mRNA therapeutics necessitate simultaneous organ-specific accumulation and effective translation. Despite some progress, delivery systems are still unable to fully achieve this. Here, we reformu...
-
Article
Benefits of Hepatitis C Viral Eradication: A Real-World Nationwide Cohort Study in Taiwan
Chronic hepatitis C (CHC) increases the risk of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). This nationwide cohort study assessed the effectiveness of viral eradication of CHC.
-
Article
Antibody–drug conjugates in gastric cancer: from molecular landscape to clinical strategies
Antibody–drug conjugates (ADCs) represent a crucial component of targeted therapies in gastric cancer, potentially altering traditional treatment paradigms. Many ADCs have entered rigorous clinical trials base...
-
Article
Open AccessABE-ultramax for high-efficiency biallelic adenine base editing in zebrafish
Advancements in CRISPR technology, particularly the development of base editors, revolutionize genetic variant research. When combined with model organisms like zebrafish, base editors significantly accelerate...
-
Article
Open AccessArtificial sweeteners and risk of incident cardiovascular disease and mortality: evidence from UK Biobank
Artificial sweeteners are widely popular worldwide as substitutes for sugar or caloric sweeteners, but there are still several important unknowns and controversies regarding their associations with cardiovascu...
-
Article
Open AccessEarly change of plasma Epstein-Barr virus DNA load and the viral lytic genome level could positively predict clinical outcome in recurrent or metastatic nasopharyngeal carcinoma receiving anti-programmed cell death 1 monotherapy
Patients with recurrent or metastatic nasopharyngeal carcinoma (RM-NPC) have proven benefit from anti-programmed cell death 1 (anti-PD-1) monotherapy. Here, we retrospectively analyze the association of plasma...
-
Article
Distribution, risk evaluation, and source allocation of cesium and strontium in surface soil in a mining city
Radioactive nuclides cesium (Cs) and strontium (Sr) possess long half-lives, with 135Cs at approximately 2.3 million years and 87Sr at about 49 billion years. Their persistent accumulation can result in long-last...
