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Article
Phase field modeling of grain stability of nanocrystalline alloys by explicitly incorporating mismatch strain
Nanocrystalline materials exhibit unique properties due to their extremely high grain boundary (GB) density. However, this high-density characteristic induces grain coarsening at elevated temperatures, thereby...
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Article
Open AccessWhich factors are associated with adverse prognosis in multiple myeloma patients after surgery? - preliminary establishment and validation of the nomogram
To investigate the prognosis of patients with Multiple Myeloma (MM) after surgery, analyze the risk factors leading to adverse postoperative outcomes, and establish a nomogram.
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Article
Open AccessCold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy
Recently, environmental temperature has been shown to regulate bone homeostasis. However, the mechanisms by which cold exposure affects bone mass remain unclear. In our present study, we observed that exposure...
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Article
Dahuang Zhechong Pill Alleviates Liver Fibrosis Progression by Regulating p38 MAPK/NF-κ B/TGF-β1 Pathway
To explore the effect and mechanism of Dahuang Zhechong Pill (DHZCP) on liver fibrosis.
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Article
Unveiling the Re, Cr, and I diffusion in saturated compacted bentonite using machine-learning methods
The safety assessment of high-level radioactive waste repositories requires a high predictive accuracy for radionuclide diffusion and a comprehensive understanding of the diffusion mechanism. In this study, a ...
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Article
Correction: Comparing Sonazoid contrast-enhanced ultrasound to contrast-enhanced CT and MRI for differentially diagnosing renal lesions: a prospective multicenter study
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Article
Kv3.1 Interaction with UBR5 Is Required for Chronic Inflammatory Pain
Chronic inflammatory pain caused by neuronal hyperactivity is a common and refractory disease. Kv3.1, a member of the Kv3 family of voltage-dependent K+ channels, is a major determinant of the ability of neurons ...
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Article
Light-induced stepped thermal relaxation in a Hofmann-type metal-organic framework
Spin-crossover (SCO) materials with light-induced multistability have potential applications in multi-addressable opto-magnetic memory devices and multiple switches. Here, we reported a three-dimensional Hofma...
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Article
Open AccessHBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis
The root of Aconitum carmichaelii Debx. (Fuzi) is an herbal medicine used in China that exerts significant efficacy in rescuing patients from severe diseases. A key toxic compound in Fuzi, aconitine (AC), could t...
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Article
Open AccessUnveiling the role of HP1α-HDAC1-STAT1 axis as a therapeutic target for HP1α-positive intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma (ICCA) is a heterogeneous group of malignant tumors characterized by high recurrence rate and poor prognosis. Heterochromatin Protein 1α (HP1α) is one of the most important nonh...
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Article
Open AccessAssociation between sodium–glucose cotransporter-2 (SGLT2) inhibitors and macular degeneration in patients with diabetes: a nationwide population-based study in Taiwan
Evidence showed that SGLT2 inhibitors have greater protective effects against retinal diseases compared to other hypoglycemic agents. Thus, we explore the association between SGLT2 inhibitor usage and macular ...
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Article
Open AccessSignal enhancement ratio of multi-phase contrast-enhanced MRI: an imaging biomarker for survival in pancreatic adenocarcinoma
To evaluate signal enhancement ratio (SER) for tissue characterization and prognosis stratification in pancreatic adenocarcinoma (PDAC), with quantitative histopathological analysis (QHA) as the reference stan...
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Article
Innovative coaxial high-temperature thin-film sensor with core–shell structure surpassing traditional multilayer films
High-temperature thin-film sensors (TFSs) often suffer from inadequate tolerance to elevated temperatures. In this study, an innovative approach is presented to fabricate in situ integrated TFSs with a core–sh...
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Article
Comparing Sonazoid contrast-enhanced ultrasound to contrast-enhanced CT and MRI for differentially diagnosing renal lesions: a prospective multicenter study
To evaluate the diagnostic performance of contrast-enhanced (CE) ultrasound using Sonazoid (SNZ–CEUS) by comparing with contrast-enhanced computed tomography (CE–CT) and contrast-enhanced magnetic resonance im...
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Article
Tough Semi-interpenetrating Polyvinylpyrrolidone/Polyacrylamide Hydrogels Enabled by Bioinspired Hydrogen-bonding Induced Phase Separation
Semi-interpenetrating (semi-IPN) hydrogels formed by the continuous interpenetration of cross-linked polymer network and linear non-crosslinked polymer with multifunctionality are widely used in biomedical and...
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Article
Open AccessFn-OMV potentiates ZBP1-mediated PANoptosis triggered by oncolytic HSV-1 to fuel antitumor immunity
Oncolytic viruses (OVs) show promise as a cancer treatment by selectively replicating in tumor cells and promoting antitumor immunity. However, the current immunogenicity induced by OVs for tumor treatment is ...
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Article
The design of the front-end layout and first high-power-density masks for the hard X-ray nano-probe beamline at SSRF
The peak power density of the hard X-ray nano-probe beamline is the highest at SSRF (Shanghai Synchrotron Radiation Facility). The peak power density of the front-end is 77.43 kW/mrad2, which is about 1.7 times h...
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Article
Open AccessOTUB1/NDUFS2 axis promotes pancreatic tumorigenesis through protecting against mitochondrial cell death
Pancreatic cancer is one of the most fatal cancers in the world. A growing number of studies have begun to demonstrate that mitochondria play a key role in tumorigenesis. Our previous study reveals that NDUFS2 (N...
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Article
Open AccessThe impact of environmental regulation on green investment efficiency of thermal power enterprises in China-based on a three-stage exogenous variable model
Due to the increased frequency of extreme weather events and the implementation of the China’s dual-carbon target, thermal power companies have been under pressure to construct green infrastructure and to acti...
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Article
Open AccessXELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial
Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...
