48 Result(s)

Article

Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease

Endoplasmic reticulum (ER)-mitochondria contacts are critical for the regulation of lipid transport, synthesis, and metabolism. However, the molecular mechanism and physiological function of endoplasmic reticu...

Jun Dong, Li Chen, Fei Ye, Junhui Tang, Bing Liu, Jiacheng Lin… in Nature Communications (2024)

Article

Gankyrin inhibits ferroptosis through the p53/SLC7A11/GPX4 axis in triple-negative breast cancer cells

Gankyrin is found in high levels in triple-negative breast cancer (TNBC) and has been established to form a complex with the E3 ubiquitin ligase MDM2 and p53, resulting in the degradation of p53 in hepatocarci...

Ming Lei, Yun-Long Zhang, Feng-Ying Huang, Heng-Yu Chen… in Scientific Reports (2023)

Article

Proteomic characterization of epithelial ovarian cancer delineates molecular signatures and therapeutic targets in distinct histological subtypes

Clear cell carcinoma (CCC), endometrioid carcinoma (EC), and serous carcinoma (SC) are the major histological subtypes of epithelial ovarian cancer (EOC), whose differences in carcinogenesis are still unclear....

Ting-Ting Gong, Shuang Guo, Fang-Hua Liu, Yun-Long Huo, Meng Zhang… in Nature Communications (2023)

Article

A single-cell transcriptional landscape of immune cells shows disease-specific changes of T cell and macrophage populations in human achalasia

Achalasia is a rare motility disorder of the esophagus caused by the gradual degeneration of myenteric neurons. Immune-mediated ganglionitis has been proposed to underlie the loss of myenteric neurons. Here, w...

Zu-Qiang Liu, Hao Dai, Lu Yao, Wei-Feng Chen, Yun Wang, Li-Yun Ma… in Nature Communications (2023)

Article

A multi-omics dataset of human transcriptome and proteome stable reference

The development of high-throughput omics technology has greatly promoted the development of biomedicine. However, the poor reproducibility of omics techniques limits their application. It is necessary to use s...

Shaohua Lu, Hong Lu, Tingkai Zheng, Huiming Yuan, Hongli Du, Youhe Gao… in Scientific Data (2023)

Article

The effectiveness of optimal exercise-based strategy for patients with hip fracture: a systematic review and Bayesian network meta-analysis

The implementation of exercise intervention (EI) presents a promising and economical way for patients with hip fracture. However, the optimal type of EI remains unclear. The objective of this study is to evalu...

Rong-jia Pan, Si-jie Gui, Yu-Lian He, Fang Nian, **ao-Yan Ni… in Scientific Reports (2023)

Article

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study o...

Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo… in Nature Communications (2023)

Article

Single-cell analysis of peripheral blood from high-altitude pulmonary hypertension patients identifies a distinct monocyte phenotype

Immune and inflammatory responses have an important function in the pathophysiology of pulmonary hypertension (PH). However, little is known about the immune landscape in peripheral circulation in patients wit...

**n-Hua Wu, Yang-Yang He, Zhang-Rong Chen, Ze-Yuan He, Yi Yan… in Nature Communications (2023)

Article

Author Correction: Genomic basis for RNA alterations in cancer

Claudia Calabrese, Natalie R. Davidson, Deniz Demircioğlu, Nuno A. Fonseca… in Nature (2023)

Article

Short term outcomes of extremely low birth weight infants from a multicenter cohort study in Guangdong of China

With the increase in extremely low birth weight (ELBW) infants, their outcome attracted worldwide attention. However, in China, the related studies are rare. The hospitalized records of ELBW infants discharged...

Chun-Hong Jia, Zhou-Shan Feng, **ao-Jun Lin, Qi-Liang Cui… in Scientific Reports (2022)

Article

Comprehensive profiling of 1015 patients’ exomes reveals genomic-clinical associations in colorectal cancer

The genetic basis of colorectal cancer (CRC) and its clinical associations remain poorly understood due to limited samples or targeted genes in current studies. Here, we perform ultradeep whole-exome sequencin...

Qi Zhao, Feng Wang, Yan-**ng Chen, Shifu Chen, Yi-Chen Yao… in Nature Communications (2022)

Article

Retraction Note: Acupuncture elicits neuroprotective effect by inhibiting NAPDH oxidase-mediated reactive oxygen species production in cerebral ischaemia

Guang-**a Shi, Xue-Rui Wang, Chao-Qun Yan, Tian He, **g-Wen Yang… in Scientific Reports (2022)

Article

Identification and regulatory network analysis of SPL family transcription factors in Populus euphratica Oliv. heteromorphic leaves

The SQUAMOSA promoter-binding protein-like (SPL) family play a key role in guiding the switch of plant growth from juvenile to adult phases. Populus euphratica Oliv. exhibit typical heterophylly, and is therefore...

Shao-Wei Qin, Liang-Hong Bao, Zhi-Gui He, Cai-Lin Li, Hong-gui La… in Scientific Reports (2022)

Article

Author Correction: Acupuncture elicits neuroprotective effect by inhibiting NAPDH oxidase-mediated reactive oxygen species production in cerebral ischaemia

Guang-**a Shi, Xue-Rui Wang, Chao-Qun Yan, Tian He, **g-Wen Yang… in Scientific Reports (2021)

Article

Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting

Esophageal cancer (EC) is a type of aggressive cancer without clinically relevant molecular subtypes, hindering the development of effective strategies for treatment. To define molecular subtypes of EC, we per...

Wei Liu, Lei **e, Yao-Hui He, Zhi-Yong Wu, Lu-**n Liu… in Nature Communications (2021)

Article

Insulin signaling regulates longevity through protein phosphorylation in Caenorhabditis elegans

Insulin/IGF-1 Signaling (IIS) is known to constrain longevity by inhibiting the transcription factor FOXO. How phosphorylation mediated by IIS kinases regulates lifespan beyond FOXO remains unclear. Here, we p...

Wen-Jun Li, Chen-Wei Wang, Li Tao, Yong-Hong Yan, Mei-Jun Zhang… in Nature Communications (2021)

Article

Gallium nitride catalyzed the direct hydrogenation of carbon dioxide to dimethyl ether as primary product

The selective hydrogenation of CO₂ to value-added chemicals is attractive but still challenged by the high-performance catalyst. In this work, we report that gallium nitride (GaN) catalyzes the direct hydrogenati...

Chang Liu, **can Kang, Zheng-Qing Huang, Yong-Hong Song… in Nature Communications (2021)

Article

CRISPRi screens reveal a DNA methylation-mediated 3D genome dependent causal mechanism in prostate cancer

Prostate cancer (PCa) risk-associated SNPs are enriched in noncoding cis-regulatory elements (rCREs), yet their modi operandi and clinical impact remain elusive. Here, we perform CRISPRi screens of 260 rCREs i...

Musaddeque Ahmed, Fraser Soares, Ji-Han **a, Yue Yang, **g Li… in Nature Communications (2021)

Article

Bimetallic nickel-molybdenum/tungsten nanoalloys for high-efficiency hydrogen oxidation catalysis in alkaline electrolytes

Hydroxide exchange membrane fuel cells offer possibility of adopting platinum-group-metal-free catalysts to negotiate sluggish oxygen reduction reaction. Unfortunately, the ultrafast hydrogen oxidation reactio...

Yu Duan, Zi-You Yu, Li Yang, Li-Rong Zheng, Chu-Tian Zhang… in Nature Communications (2020)

Article

Isolation of two rare N-glycosides from Ginkgo biloba and their anti-inflammatory activities

Two rare N-β-D-glucopyranosyl-1H-indole-3-acetic acid conjugates, N-[2-(1-β-D-glucopyranosyl)-1H-indol-3-yl)acetyl]-L-glutamic acid (1) and N-[2-(1-β-D-glucopyranosyl)-1H-indol-3-yl)acetyl]-L-aspartic acid (2) we...

**-Tang Cheng, Cong Guo, Wen-** Cui, Qing Zhang, Shu-Hui Wang… in Scientific Reports (2020)