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Article
Design and prototy** of the readout electronics for the transition radiation detector in the high energy cosmic radiation detection facility
The high energy cosmic-radiation detection (HERD) facility is planned to launch in 2027 and scheduled to be installed on the China Space Station. It serves as a dark matter particle detector, a cosmic ray inst...
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Article
Feature Analysis Network: An Interpretable Idea in Deep Learning
Deep Learning (DL) stands out as a leading model for processing high-dimensional data, where the nonlinear transformation of hidden layers effectively extracts features. However, these unexplainable features m...
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Article
Open AccessLiquid-liquid phase separation in DNA double-strand breaks repair
DNA double-strand breaks (DSBs) are the fatal type of DNA damage mostly induced by exposure genome to ionizing radiation or genotoxic chemicals. DSBs are mainly repaired by homologous recombination (HR) and no...
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Article
Open AccessUpregulation of WDR6 drives hepatic de novo lipogenesis in insulin resistance in mice
Under normal conditions, insulin promotes hepatic de novo lipogenesis (DNL). However, during insulin resistance (IR), when insulin signalling is blunted and accompanied by hyperinsulinaemia, the promotion of h...
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Article
Effect and Mechanism of Sodium Butyrate on Neuronal Recovery and Prognosis in Diabetic Stroke
Ischemic stroke is a cerebrovascular lesion caused by local ischemia and hypoxia. Diabetes mellitus (DM) is a chronic inflammatory disease that disturbs immune homeostasis and predisposes patients to ischemic ...
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Article
Development and Verification of Fatigue Testing Device for Rail Fastening Clamps
The rail fastening clamp (or clip) is a crucial part of the rail fastening system that links the rail to the sleeper and transmits the trainload to the substructure. Due to the large tensile stress that occurs...
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Article
Open AccessEffects of neoadjuvant radiochemotherapy for anorectal function in locally advanced rectal cancer patients: a study protocol for a prospective, observational, controlled, multicentre study
Neoadjuvant chemoradiotherapy (NCRT) and total mesorectal excision are standard treatment regimen for patients with locally advanced rectal cancer (LARC). This sphincter-saving treatment strategy may be accomp...
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Article
Open AccessA randomized trial of Trendelenburg position for acute moderate ischemic stroke
We aim to explore the effect of head-down position (HDP), initiated within 24 hours of onset, in moderate anterior circulation stroke patients with probable large artery atherosclerosis (LAA) etiology. This in...
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Article
Geodynamic processes of the southeastern Neo-Tethys Ocean and the formation mechanism of the curved subduction system in Southeast Asia
Southeast Asia is located at the intersection of the Tethys and Pacific domains. The superimposed effects of the two tectonic domains have resulted in complicated deep structure, surface magma responses, and d...
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Article
Effect of Wrist-Ankle Acupuncture on Postoperative Analgesia after Total Knee Arthroplasty
To evaluate the effect of wrist-ankle acupuncture (WAA) in pain and functional recovery after total knee arthroplasty (TKA).
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Article
Open AccessRecognizing and monitoring infectious sources of schistosomiasis by develo** deep learning models with high-resolution remote sensing images
China is progressing towards the goal of schistosomiasis elimination, but there are still some problems, such as difficult management of infection source and snail control. This study aimed to develop deep lea...
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Article
Laser irradiation of graphite foils as robust current collectors for high-mass loaded electrodes of supercapacitors
Conductive substrates with low cost, lightweight, and chemical stability have been highly recognized as alternative current collectors for energy storage devices. Graphite foil is promising to fulfill these re...
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Article
Open AccessDNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0
Paraspeckles are mammal-specific membraneless nuclear bodies that participate in various biological processes. NONO, a central paraspeckle component, has been shown to play pivotal roles in DNA double-strand b...
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Article
A pyroptosis nanotuner for cancer therapy
Pyroptosis is a gasdermin-mediated programmed necrosis that occurs via membrane perforation and that can be exploited for biomedical applications in cancer therapy. However, inducing specific pyroptotic cancer...
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Article
Open AccessSandstorms cause shrinkage of Haloxylon ammodendron shrubs and limit their self-renewal
Haloxylon ammodendron is an excellent windproof and sand-fixing species whose shrubs are widely cultivated in arid desert areas of northwest China but are now at risk of degradation and shrinkage. Using the chlor...
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Article
Open AccessMRNIP condensates promote DNA double-strand break sensing and end resection
The rapid recognition of DNA double-strand breaks (DSBs) by the MRE11/RAD50/NBS1 (MRN) complex is critical for the initiation of DNA damage response and DSB end resection. Here, we show that MRN complex intera...
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Article
Molecular Epidemiology and Risk Factors of Carbapenem-Resistant Klebsiella Pneumoniae Bloodstream Infections in Wuhan, China
The clinical characteristics and microbiological data of patients with K. pneumoniae bloodstream infections (BSI) from January 2018 to December 2020 were retrospectively analyzed to study the molecular epidemiolo...
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Article
mTOR regulates cocaine-induced behavioural sensitization through the SynDIG1–GluA2 interaction in the nucleus accumbens
Behavioral sensitization is a progressive increase in locomotor or stereotypic behaviours in response to drugs. It is believed to contribute to the reinforcing properties of drugs and to play an important role...
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Chapter and Conference Paper
Research on Big Data Ad Hoc Queries Technology Based on Social Network Information Cognitive Model
In order to improve the efficiency of big data ad hoc query, a big data ad hoc query technology based on social network information cognitive model is designed. Firstly, the hierarchical structure of data quer...
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Article
Open AccessHematopoietic stem cell transplantation activity in China 2019: a report from the Chinese Blood and Marrow Transplantation Registry Group
Between 2008 and 2019, 58,914 hematopoietic stem cell transplantations (HSCTs) were reported to the Chinese Blood and Marrow Transplantation Registry Group (CBMTRG) throughout China. In this report, we focus o...
