130 Result(s)
-
Chapter
Fluid Transport by Human Nonpigmented Ciliary Epithelial Monolayer
Ciliary epithelium is responsible for the secretion of aqueous humor into posterior chamber of the eye. Most of aqueous humor secretion is driven by the active transport of ions from plasma into the posterior ...
-
Article
Functional characterization of β-ketoacyl-CoA synthase genes from Brassica napus L.
Seed-specifically expressed β-ketoacyl-CoA synthase genes of Brassica napus (Bn-FAE1.1 genes) were cloned from two cultivars, namely Askari, a high-erucic-acid type, and Drakkar, a low-erucic-acid type. The genes...
-
Chapter
Cloning of Human Intestinal Taurine Transporter and Production of Polyclonal Antibody
Taurine (2-ethaneaminosulfonic acid, +NH3CH2CH2SO3) is an endogenous amino acid which functions as a modulator of transmembrane calcium transport, an osmoregulator and, putatively a free radical scavenger1. In ut...
-
Chapter
Brassica KCS is Capable of Elongating Polyunsaturated Fatty Acids
Polyunsaturated fatty acids (PUFAs) with more than 18 carbons in length are essential constituents functioning in membrane fluidity, signal transduction, and eicosanoid production. The biosynthesis of PUFAs re...
-
Article
Biodegradation of exploded cotton stalk by Bacillus sp.
The exploded bast, branch and stem of cotton stalk were degraded by alkalophilic Bacillus NT-19, with weight losses of 24%, 20% and 14%, respectively, after 14 d. Compared with a white-rot fungus (Phanerochaete c...
-
Article
A novel recently evolved gene C19orf24 encodes a non-classical secreted protein
Secreted proteins play important roles in many crucial biological processes, and can be new agents or targets for drug therapies. Here, we report on the isolation and characterization of a novel human non-clas...
-
Article
ZBTB34, a novel human BTB/POZ zinc finger protein, is a potential transcriptional repressor
BTB/POZ protein family plays a key role in many biological processes both in Drosophila and vertebrates through regulating the transcriptional activities of some downstream genes. Here, we obtained a novel member...
-
Article
Involvement of MGr1-Ag/37LRP in the vincristine-induced HIF-1 expression in gastric cancer cells
Drug resistance is a major obstacle in the development of effective cancer therapy. It was reported that many chemotherapeutic drugs such as vincristine (VCR), a potent anti-tumor agent that associates with mi...
-
Article
Hypoxia induced HIF-1 accumulation and VEGF expression in gastric epithelial mucosa cells: Involvement of ERK1/2 and PI3K/Akt
Hypoxia is a common environmental stress that influences signaling pathways and cell function, which through initiates intracellular signaling pathways and hence leads to the activation of the transcription fa...
-
Article
hBolA, novel non-classical secreted proteins, belonging to different BolA family with functional divergence
This study reported that all three human BolA proteins (hBolA1, hBolA2, and hBolA3) are novel non-classical secreted proteins identified with bioinformatics and molecular biology experiments. The three BolA fu...
-
Article
Liver-specific ZP domain-containing protein (LZP) as a new partner of Tamm-Horsfall protein harbors on renal tubules
Liver-specific ZP domain-containing protein (LZP) was recently identified as a secreted protein that is specifically expressed in liver. However, the physiological effects of LZP are largely unknown. In this s...
-
Article
Ankrd7, a novel gene specifically expressed in Sertoli cells and its potential roles in Sertoli cell maturation
The somatic Sertoli cells play an essential role in testis determination and spermatogenesis by providing nutrition and structural support. In the current study, we report on the novel Ankrd7 gene that contain...
-
Article
Expression of a novel gene FAM43B repressing cell proliferation is regulated by DNA methylation in hepatocellular carcinoma cell lines
The epigenetic dysregulation of tumor suppressor genes plays an important role in many cancers, including hepatocellular carcinoma (HCC). In this study, we identified a new gene, family with sequence similarit...
-
Article
Design, synthesis and 3D-QSAR study of cytotoxic flavonoid derivatives
Three series of flavonoid derivatives were designed and synthesized. All synthesized compounds were evaluated for cytotoxic activities against five human cancer cell lines, including K562, PC-3, MCF-7, A549, a...
-
Article
Antiviral resistance mutations potentiate HBV surface antigen-induced transcription of hfgl2 prothrombinase gene
Antiviral resistance mutations in the hepatitis B virus (HBV) polymerase (pol) gene have been demonstrated to play an important role in the progression of liver disease and the development of hepatocellular carci...
-
Article
Parallel synthesis of novel antitumor agents: 1,2,3-triazoles bearing biologically active sulfonamide moiety and their 3D-QSAR
A 60-member 1,2,3-triazoles bearing biologically active sulfonamide moiety library was synthesized via azide–alkyne cycloaddition and examined for cytotoxic activity against human leukemia cell line HL-60. 25 ...
-
Article
Selection and optimization of asymmetric siRNA targeting the human c-MET gene
The silencing of specific oncogenes via RNA interference (RNAi) holds great promise for the future of cancer therapy. RNAi is commonly carried out using small interfering RNA (siRNA) composed of a 19 bp duplex...
-
Article
Comparison of the structural basis for thermal stability between archaeal and bacterial proteins
In this study, the structural basis for thermal stability in archaeal and bacterial proteins was investigated. There were many common factors that confer resistance to high temperature in both archaeal and bac...
-
Article
Meridian is a Three-Dimensional Network from Bio-Electromagnetic Radiation Interference: An Interference Hypothesis of Meridian
An electromagnetic radiation field within a biological organism is characterized by non-local interference. The interfering beams form a unitary tridimensional network with beams of varying intensity, also cal...
-
Article
Mathematical Model of Biological Order State or Syndrome in Traditional Chinese Medicine: Based on Electromagnetic Radiation within the Human Body
In this study, based on the resonator model and exciplex model of electromagnetic radiation within the human body, mathematical model of biological order state, also referred to as syndrome in traditional Chin...
