37 Result(s)

Article

USP47 deficiency in mice modulates tumor infiltrating immune cells and enhances antitumor immune responses in prostate cancer

This study investigates the role of USP47, a deubiquitinating enzyme, in the tumor microenvironment and its impact on antitumor immune responses. Analysis of TCGA database revealed distinct expression patterns...

Qian-Lan Wang, Shun-Yuan Lu, Dan-Dan Xu, **-**a Ma… in Cancer Immunology, Immunotherapy (2024)

Article

Contrast-enhanced CT radiomics features to preoperatively identify differences between tumor and proximal tumor-adjacent and tumor-distant tissues of resectable esophageal squamous cell carcinoma

Esophagectomy is the main treatment for esophageal squamous cell carcinoma (ESCC), and patients with histopathologically negative margins still have a relatively higher recurrence rate. Contrast-enhanced CT (C...

Dan Gao, Bang-guo Tan, **ao-qian Chen, Chuanqinyuan Zhou, **g Ou… in Cancer Imaging (2024)

Article

LncRNA expression signature identified using genome-wide transcriptomic profiling to predict lymph node metastasis in patients with stage T1 and T2 gastric cancer

Lymph node (LN) status is vital to evaluate the curative potential of relatively early gastric cancer (GC; T1–T2) treatment (endoscopic or surgery). Currently, there is a lack of robust and convenient methods ...

Zhe-bin Dong, Han-ting **ang, Heng-miao Wu, **an-lei Cai, Zheng-wei Chen… in Gastric Cancer (2023)

Article

Predictors for delayed awakening in adult glioma patients receiving awake craniotomy under monitored anesthesia care

Delayed awakening after anesthetic discontinuation during awake craniotomy is associated with somnolence during functional brain map**. However, predictors of delayed awakening in patients receiving monitore...

Huan-Tang Lin, Chun-Ming Lin, Yah-Yuan Wu, Wei-Han Chang… in Journal of Neuro-Oncology (2023)

Article

Decreased B4GALT1 promotes hepatocellular carcinoma cell invasiveness by regulating the laminin-integrin pathway

Beta1,4-galactosyltransferases (B4GALTs) play a crucial role in several diseases, including cancer. B4GALT1 is highly expressed in the liver, and patients with mutations in B4GALT1 exhibit hepatopathy. However, t...

Po-Da Chen, Ying-Yu Liao, Yu-Chia Cheng, Hsin-Yi Wu, Yao-Ming Wu… in Oncogenesis (2023)

Article

Plasma cell-free tumor DNA, PIK3CA and TP53 mutations predicted inferior endocrine-based treatment outcome in endocrine receptor-positive metastatic breast cancer

How to factor both tumor burden and oncogenic genomic mutations as variables to predict the outcome of endocrine-based therapy (ET) in ER-positive/HER2-negative metastatic breast cancer patients (MBC) remains ...

Tom Wei-Wu Chen, Wen Hsiao, Ming-Shen Dai… in Breast Cancer Research and Treatment (2023)

Article

Real-world evidence of osimertinib in Chinese patients with EGFR T790M-positive non-small cell lung cancer: a subgroup analysis from ASTRIS study

ASTRIS study aimed the largest to evaluate the effectiveness and safety of second- or higher-line osimertinib in patients with advanced/metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive n...

Qing Zhou, He-Long Zhang, Li-Yan Jiang… in Journal of Cancer Research and Clinical On… (2023)

Article

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...

Hai-Dong Zhu, Hai-Liang Li, Ming-Sheng Huang… in Signal Transduction and Targeted Therapy (2023)

Article

The development of a cSMART-based integrated model for hepatocellular carcinoma diagnosis

Hepatocellular carcinoma (HCC) generally arises from a background of liver cirrhosis (LC). Patients with cirrhosis and suspected HCC are recommended to undergo serum biomarker tests and imaging diagnostic eval...

Tong Wu, Rong Fan, Jian Bai, Zhao Yang, Yun-Song Qian… in Journal of Hematology & Oncology (2023)

Article

Targeted demethylation at ZNF154 promotor upregulates ZNF154 expression and inhibits the proliferation and migration of Esophageal Squamous Carcinoma cells

Zinc finger protein 154 (ZNF154) is hypermethylated at the promoter in many epithelial-derived solid tumors. However, its methylation status and function in esophageal squamous carcinoma (ESCC) are poorly unde...

Wenting He, Shiyong Lin, Yi Guo, Yuanzhong Wu, Lu-Lu Zhang, Qiling Deng… in Oncogene (2022)

Article

Correction to: Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1

Chen-Fei Zhou, **g Ma, Lei Huang, Hong-Yan Yi, Yan-Mei Zhang, **ang-Guang Wu… in Oncogene (2022)

Article

Benefit of [18F]-FDG PET/CT for treatment-naïve nasopharyngeal carcinoma

To test the advantages of positron emission tomography and computed tomography (PET/CT) for diagnosing lymph nodes and staging nasopharyngeal carcinoma and to investigate its benefits for survival and treatmen...

Shan-Shan Yang, Yi-Shan Wu, Wei-Chao Chen… in European Journal of Nuclear Medicine and M… (2022)

Article

The Long-Term Clinical Impact of Thoracic Endovascular Aortic Repair (TEVAR) for Advanced Esophageal Cancer Invading Aorta

Advanced esophageal cancer invading the aorta is considered unsuitable for surgery with definitive chemotherapy or chemoradiation as the treatments of choice. In the current study, we evaluated the long-term c...

Ke-Cheng Chen MD, PhD, I-Hui Wu MD, PhD… in Annals of Surgical Oncology (2021)

Article

Safety and efficacy of thalidomide in patients with transfusion-dependent β-thalassemia: a randomized clinical trial

Thalidomide induces γ-globin expression in erythroid progenitor cells, but its efficacy on patients with transfusion-dependent β-thalassemia (TDT) remains unclear. In this phase 2, multi-center, randomized, do...

Jiang-Ming Chen, Wei-Jian Zhu, Jie Liu… in Signal Transduction and Targeted Therapy (2021)

Article

Development and validation of a novel online calculator for estimating survival benefit of adjuvant transcatheter arterial chemoembolization in patients undergoing surgery for hepatocellular carcinoma

Although adjuvant transcatheter arterial chemoembolization (TACE) for resected hepatocellular carcinoma (HCC) may improve survival for some patients, identifying which patients can benefit remains challenging....

Lei Liang, Chao Li, Ming-Da Wang, Hong Wang… in Journal of Hematology & Oncology (2021)

Article

NR4A3 and CCL20 clusters dominate the genetic networks in CD146⁺ blood cells during acute myocardial infarction in humans

CD146 is a tight junction-associated molecule involved in maintaining endothelial barrier, and balancing immune–inflammation response, in cardiovascular disease. Notably, peripheral CD146⁺ cells significantly ups...

Yan-hui Wang, Chen-xin Li, Jessica M. Stephenson… in European Journal of Medical Research (2021)

Article

The consensus from The Chinese Society of Hematology on indications, conditioning regimens and donor selection for allogeneic hematopoietic stem cell transplantation: 2021 update

The consensus recommendations in 2018 from The Chinese Society of Hematology (CSH) on indications, conditioning regimens and donor selection for allogeneic hematopoietic stem cell transplantation (allo-HSCT) f...

**ao-hui Zhang, **g Chen, Ming-Zhe Han, He Huang… in Journal of Hematology & Oncology (2021)

Article

Clinical characteristics and immunological abnormalities of Castleman disease complicated with autoimmune diseases

To explore the clinical features and immunological mechanisms of Castleman disease (CD) complicated with autoimmune diseases (AID).

Dao-** Sun, Wen-Ming Chen, Li Wang… in Journal of Cancer Research and Clinical On… (2021)

Article

Small molecules in targeted cancer therapy: advances, challenges, and future perspectives

Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs, targeted therapeutic drugs have become mainstream cancer treatments. Since the first tyrosine kinase inhibitor imatini...

Lei Zhong, Yueshan Li, Liang **ong… in Signal Transduction and Targeted Therapy (2021)

Article

The M1/M2 spectrum and plasticity of malignant pleural effusion-macrophage in advanced lung cancer

Malignant pleural effusion (MPE)-macrophage (Mφ) of lung cancer patients within unique M1/M2 spectrum showed plasticity in M1–M2 transition. The M1/M2 features of MPE-Mφ and their significance to patient outco...

Ming-Fang Wu, Chih-An Lin, Tzu-Hang Yuan… in Cancer Immunology, Immunotherapy (2021)