14 Result(s)

Article

Decreased B4GALT1 promotes hepatocellular carcinoma cell invasiveness by regulating the laminin-integrin pathway

Beta1,4-galactosyltransferases (B4GALTs) play a crucial role in several diseases, including cancer. B4GALT1 is highly expressed in the liver, and patients with mutations in B4GALT1 exhibit hepatopathy. However, t...

Po-Da Chen, Ying-Yu Liao, Yu-Chia Cheng, Hsin-Yi Wu, Yao-Ming Wu… in Oncogenesis (2023)

Article

Real-world evidence of osimertinib in Chinese patients with EGFR T790M-positive non-small cell lung cancer: a subgroup analysis from ASTRIS study

ASTRIS study aimed the largest to evaluate the effectiveness and safety of second- or higher-line osimertinib in patients with advanced/metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive n...

Qing Zhou, He-Long Zhang, Li-Yan Jiang… in Journal of Cancer Research and Clinical On… (2023)

Article

Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma (CHANCE001)

There is considerable potential for integrating transarterial chemoembolization (TACE), programmed death-(ligand)1 (PD-[L]1) inhibitors, and molecular targeted treatments (MTT) in hepatocellular carcinoma (HCC...

Hai-Dong Zhu, Hai-Liang Li, Ming-Sheng Huang… in Signal Transduction and Targeted Therapy (2023)

Article

Targeted demethylation at ZNF154 promotor upregulates ZNF154 expression and inhibits the proliferation and migration of Esophageal Squamous Carcinoma cells

Zinc finger protein 154 (ZNF154) is hypermethylated at the promoter in many epithelial-derived solid tumors. However, its methylation status and function in esophageal squamous carcinoma (ESCC) are poorly unde...

Wenting He, Shiyong Lin, Yi Guo, Yuanzhong Wu, Lu-Lu Zhang, Qiling Deng… in Oncogene (2022)

Article

Correction to: Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1

Chen-Fei Zhou, **g Ma, Lei Huang, Hong-Yan Yi, Yan-Mei Zhang, **ang-Guang Wu… in Oncogene (2022)

Article

Safety and efficacy of thalidomide in patients with transfusion-dependent β-thalassemia: a randomized clinical trial

Thalidomide induces γ-globin expression in erythroid progenitor cells, but its efficacy on patients with transfusion-dependent β-thalassemia (TDT) remains unclear. In this phase 2, multi-center, randomized, do...

Jiang-Ming Chen, Wei-Jian Zhu, Jie Liu… in Signal Transduction and Targeted Therapy (2021)

Article

NR4A3 and CCL20 clusters dominate the genetic networks in CD146⁺ blood cells during acute myocardial infarction in humans

CD146 is a tight junction-associated molecule involved in maintaining endothelial barrier, and balancing immune–inflammation response, in cardiovascular disease. Notably, peripheral CD146⁺ cells significantly ups...

Yan-hui Wang, Chen-xin Li, Jessica M. Stephenson… in European Journal of Medical Research (2021)

Article

Clinical characteristics and immunological abnormalities of Castleman disease complicated with autoimmune diseases

To explore the clinical features and immunological mechanisms of Castleman disease (CD) complicated with autoimmune diseases (AID).

Dao-** Sun, Wen-Ming Chen, Li Wang… in Journal of Cancer Research and Clinical On… (2021)

Article

Small molecules in targeted cancer therapy: advances, challenges, and future perspectives

Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs, targeted therapeutic drugs have become mainstream cancer treatments. Since the first tyrosine kinase inhibitor imatini...

Lei Zhong, Yueshan Li, Liang **ong… in Signal Transduction and Targeted Therapy (2021)

Article

Targeting autophagy as a therapeutic strategy for identification of liganans from Peristrophe japonica in Parkinson’s disease

An-Guo Wu, Rong Pan, Betty Yuen-Kwan Law… in Signal Transduction and Targeted Therapy (2021)

Article

Validation of nomogram-revised risk index and comparison with other models for extranodal nasal-type NK/T-cell lymphoma in the modern chemotherapy era: indication for prognostication and clinical decision-making

Derived from our original nomogram study by using the risk variables from multivariable analyses in the derivation cohort of 1383 patients with extranodal NK/T-cell lymphoma, nasal-type (ENKTCL) who were mostl...

Si-Ye Chen, Yong Yang, Shu-Nan Qi, Ying Wang, Chen Hu, **a He, Li-Ling Zhang… in Leukemia (2021)

Article

Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1

Cancer-secreted exosomal miRNAs are emerging mediators of cancer-stromal cross-talk in the tumor environment. Our previous miRNAs array of cervical squamous cell carcinoma (CSCC) clinical specimens identified ...

Chen-Fei Zhou, **g Ma, Lei Huang, Hong-Yan Yi, Yan-Mei Zhang, **ang-Guang Wu… in Oncogene (2019)

Article

An analysis of the association between a polymorphism of KCNJ11 and diabetic retinopathy in a Chinese Han population

Genome-wide association studies (GWAS) have reported that the polymorphism rs5219 of the potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) is associated with type 2 diabetes mellitus (T2DM). ...

Nai-Jia Liu, Hui-Hui Wu, Yan-Liang Li, Zhen Yang… in European Journal of Medical Research (2015)

Article

IGF2BP2 and obesity interaction analysis for type 2 diabetes mellitus in Chinese Han population

The objective of this study was to systematically evaluate the contribution of the insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) to type 2 diabetes mellitus (T2DM) and its interaction with obesity...

Hui-Hui Wu, Nai-Jia Liu, Zhen Yang, **ao-Ming Tao… in European Journal of Medical Research (2014)