1,538 Result(s)
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**an-Yang Wang
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Article
Navβ2 Intracellular Fragments Contribute to Aβ1-42-Induced Cognitive Impairment and Synaptic Deficit Through Transcriptional Suppression of BDNF
A pathological hallmark of Alzheimer’s disease (AD) is the region-specific accumulation of the amyloid-beta protein (Aβ), which triggers aberrant neuronal excitability, synaptic impairment, and progressive cog...
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A new tau dephosphorylation-targeting chimera for the treatment of tauopathies
Abnormal accumulation of hyperphosphorylated tau protein plays a pivotal role in a collection of neurodegenerative diseases named tauopathies, including Alzheimer’s disease (AD). We have recently conceptualize...
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Acetylcytidine modification of Amotl1 by N-acetyltransferase 10 contributes to cardiac fibrotic expansion in mice after myocardial infarction
Cardiac fibrosis is a pathological scarring process that impairs cardiac function. N-acetyltransferase 10 (Nat10) is recently identified as the key enzyme for the N4-acetylcytidine (ac4C) modification of mRNAs...
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Epstein-Barr virus causes vascular abnormalities in epithelial malignancies through upregulating ANXA3-HIF-1α-VEGF pathway
Angiogenesis is one of the characteristics of malignant tumors, and persistent generation of abnormal tumor blood vessels is an important factor contributing to tumor treatment resistance. Epstein-Barr virus (...
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Plastome structure, phylogeny and evolution of plastid genes in Reevesia (Helicteroideae, Malvaceae)
Reevesia is an eastern Asian-eastern North American disjunction genus in the family Malvaceae s.l. and comprises approximately 25 species. The relationships within the genus are not well understood. Here, 15 plas...
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Open AccessNotoginsenoside R1 promotes Lgr5+ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling
Inflammatory bowel disease (IBD) is characterized by persistent damage to the intestinal barrier and excessive inflammation, leading to increased intestinal permeability. Current treatments of IBD primarily ad...
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Clinical implications of CSF-ctDNA positivity in newly diagnosed diffuse large B cell lymphoma
The clinical implications of CSF-ctDNA positivity in newly diagnosed diffuse large B cell lymphoma (ND-DLBCL) remains largely unexplored. One hundred ND-DLBCL patients were consecutively enrolled as training c...
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Open AccessYAP inhibition overcomes adaptive resistance in HER2-positive gastric cancer treated with trastuzumab via the AKT/mTOR and ERK/mTOR axis
Human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC) is a heterogeneous GC subtype characterized by the overexpression of HER2. To date, few specific targeted therapies have demonstrate...
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Article
An Improved Grey Relational Theory Evaluation Method: Considering the Comprehensive Performance of Autonomous Vehicles in Virtual Test
Reasonable test scenarios and objective evaluation methods can rapidly promote the development of autonomous vehicle technology. A new quantitative evaluation method for the comprehensive performance of autono...
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Open AccessMocFormer: A Two-Stage Pre-training-Driven Transformer for Drug–Target Interactions Prediction
Drug–target interactions is essential for advancing pharmaceuticals. Traditional drug–target interaction studies rely on labor-intensive laboratory techniques. Still, recent advancements in computing power hav...
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Open AccessCold exposure-induced plasma exosomes impair bone mass by inhibiting autophagy
Recently, environmental temperature has been shown to regulate bone homeostasis. However, the mechanisms by which cold exposure affects bone mass remain unclear. In our present study, we observed that exposure...
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Open AccessCorrection: Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson’s disease
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Role of inclination angle on columnar-to-equiaxed transition in the eutectic Al-5Mg-2Si alloy fabricated by laser powder bed fusion
In this study, the effect of inclination angles relative to the building direction in the additively manufactured eutectic Al-5Mg-2Si alloy was investigated through the laser powder bed fusion (LPBF). The micr...
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Influence of pier height on the safety of trains running on high-speed railway bridges during earthquakes
Sudden earthquakes pose a threat to the running safety of trains on high-speed railway bridges, and the stiffness of piers is one of the factors affecting the dynamic response of train-track-bridge system. In ...
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Open AccessSusceptibility gene identification and risk evaluation model construction by transcriptome-wide association analysis for salt sensitivity of blood pressure
Salt sensitivity of blood pressure (SSBP) is an intermediate phenotype of hypertension and is a predictor of long-term cardiovascular events and death. However, the genetic structures of SSBP are uncertain, an...
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Open AccessThe role of transforming growth factor-β (TGF-β) in the formation of exhausted CD8 + T cells
CD8 + T cells exert a critical role in eliminating cancers and chronic infections, and can provide long-term protective immunity. However, under the exposure of persistent antigen, CD8 + T cells can differenti...
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A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
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Effect of mineralized dentin matrix on the prognosis of bone defect and retained root after coronectomy
To investigate the impact of mineralized dentin matrix (MDM) on the prognosis on bone regeneration and migration of retained roots after coronectomy.
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Open AccessGenome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers
Dysregulation of enhancer transcription occurs in multiple cancers. Enhancer RNAs (eRNAs) are transcribed products from enhancers that play critical roles in transcriptional control. Characterizing the genetic...
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Metabolomics efficiently discriminates monozygotic twins in peripheral blood
Monozygotic (MZ) twins cannot be distinguished using conventional forensic STR ty** because they present identical STR genoty**s. However, MZ twins do not always live in the same environment and often have...
