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  1. Article

    Open Access

    Herbal medicine formula Huazhuo Tiaozhi granule ameliorates dyslipidaemia via regulating histone lactylation and miR-155-5p biogenesis

    Huazhuo Tiaozhi granule (HTG) is a herbal medicine formula widely used in clinical practice for hypolipidaemic effects. However, the molecular mechanisms underlying dyslipidaemia treatment have not been well e...

    **angjun Yin, Min Li, Yongzhi Wang, Guifang Zhao, Tao Yang… in Clinical Epigenetics (2023)

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    Article

    Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer

    To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loc...

    **young Byun, Younghun Han, Yafang Li, Jun **a, Er** Long… in Nature Genetics (2022)

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    Article

    Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

    We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the...

    Anubha Mahajan, Cassandra N. Spracklen, Weihua Zhang, Maggie C. Y. Ng… in Nature Genetics (2022)

  4. No Access

    Article

    Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma

    Zhu Chen, Sai-Juan Chen, Wei-Li Zhao and colleagues identify recurrent loss-of-function mutations in the RNA helicase gene DDX3X in 20% of subjects with natural killer/T-cell lymphoma (NKTCL) in their study. The ...

    Lu Jiang, Zhao-Hui Gu, Zi-Xun Yan, **a Zhao, Yin-Yin **e, Zi-Guan Zhang… in Nature Genetics (2015)

  5. No Access

    Article

    Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations

    Dongxin Lin, Philip Taylor, Li-Dong Wang and colleagues have now pooled three genome-wide association analyses of esophageal squamous cell carcinoma, finding two new risk loci at genome-wide significance and a...

    Chen Wu, Zhaoming Wang, **n Song, **ao-Shan Feng, Christian C Abnet… in Nature Genetics (2014)

  6. No Access

    Article

    The genomic landscape of nasopharyngeal carcinoma

    De-Chen Lin and colleagues report whole-exome sequencing, targeted sequencing and SNP array analysis of 128 cases of nasopharyngeal carcinoma (NPC), a tumor type connected to Epstein-Barr virus infection. Thei...

    De-Chen Lin, Xuan Meng, Masaharu Hazawa, Yasunobu Nagata… in Nature Genetics (2014)

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    Article

    A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

    Montserrat Garcia-Closas and colleagues report a genome-wide association study for bladder cancer. They identify three new susceptibility loci on chromosomes 22q13.1, 19q12 and 2q37.1.

    Nathaniel Rothman, Montserrat Garcia-Closas, Nilanjan Chatterjee… in Nature Genetics (2010)

  8. No Access

    Article

    Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC

    Youwen Zhou and Xue-Jun Zhang and colleagues report a genome-wide association study of generalized vitiligo, a common autoimmune disorder characterized by loss of melanocytes and depigmentation. The authors id...

    Cheng Quan, Yun-Qing Ren, Lei-Hong **ang, Liang-Dan Sun, Ai-E Xu… in Nature Genetics (2010)

  9. No Access

    Article

    Genetics of osteoporosis: accelerating pace in gene identification and validation

    Osteoporosis is characterized by low bone mineral density and structural deterioration of bone tissue, leading to an increased risk of fractures. It is the most common metabolic bone disorder worldwide, affect...

    Wen-Feng Li, Shu-Xun Hou, Bin Yu, Meng-Meng Li, Claude Férec… in Human Genetics (2010)