-
Article
Multiplex cerebrospinal fluid proteomics identifies biomarkers for diagnosis and prediction of Alzheimer’s disease
Recent expansion of proteomic coverage opens unparalleled avenues to unveil new biomarkers of Alzheimer’s disease (AD). Among 6,361 cerebrospinal fluid (CSF) proteins analysed from the ADNI database, YWHAG per...
-
Article
Rhenium-boosted electrocatalytic activity and durability of pyrolytic IrO2 for acidic oxygen evolution
-
Article
The Effect of Antihyperglycemic Medications on COVID-19: A Meta-analysis and Systematic Review from Observational Studies
Diabetes, a chronic disease worldwide, may be associated with a poorer prognosis in patients with coronavirus disease 2019 (COVID-19). While some antihyperglycemic medications may be beneficial, others may inc...
-
Article
Microstructures and mechanical properties of laser-directed energy deposited CrCoNi medium-entropy alloy
The distinctive intrinsic heat treatment (IHT) originating from cyclic reheating in the laser-directed energy deposition (LDED) has attracted growing attention in recent years. In this investigation, simulatio...
-
Article
Response Mechanism of Dynamic Tensile Mechanics in Granite Under Microwave Irradiation: Insights from Experiments and Simulations
Microwave-assisted mechanical rock-breaking can effectively solve the problems of low efficiency of hard rock-breaking and severe wear and tear of equipment. This study used granite as the research object and ...
-
Article
Interweaving of self-regulated learning and game-based learning in higher education: a review of academic publications from 2009 to 2020
Researchers have indicated the importance of engaging learners in self-regulated learning (SRL) states when situated in game-based learning contexts; however, it remains a challenge for both educational and ed...
-
Article
Open AccessLandform and lithospheric development contribute to the assembly of mountain floras in China
Although it is well documented that mountains tend to exhibit high biodiversity, how geological processes affect the assemblage of montane floras is a matter of ongoing research. Here, we explore landform-spec...
-
Article
Urolithin A promotes atherosclerotic plaque stability by limiting inflammation and hypercholesteremia in Apolipoprotein E–deficient mice
Urolithin A (UroA), a dietary phytochemical, is produced by gut bacteria from fruits rich in natural polyphenols ellagitannins (ETs). The efficiency of ETs metabolism to UroA in humans depends on gut microbiot...
-
Article
Open AccessGenome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers
Dysregulation of enhancer transcription occurs in multiple cancers. Enhancer RNAs (eRNAs) are transcribed products from enhancers that play critical roles in transcriptional control. Characterizing the genetic...
-
Article
Open AccessLeptin receptor neurons in the ventral premammillary nucleus modulate emotion-induced insomnia
-
Article
Exploring the Interplay between Local Chain Structure and Stress Distribution in Polymer Networks
The mechanical behavior of polymer networks is intrinsically correlated with the local chain topology and chain connectivity. In this study, we delve into this relationship through the lens of coarse-grained m...
-
Article
Radical involved reactive wetting and retarding mechanism of alumina refractory ceramic by molten slags under weak static magnetic field
High alumina slag will cause severe corrosion at the interface of alumina refractory, and the wetting behavior of slag is a key factor influencing the corrosion resistance of refractory ceramics. The static ma...
-
Article
Open AccessAdvancing skeletal health and disease research with single-cell RNA sequencing
Orthopedic conditions have emerged as global health concerns, impacting approximately 1.7 billion individuals worldwide. However, the limited understanding of the underlying pathological processes at the cellu...
-
Article
Open AccessPhysical frailty, genetic predisposition, and incident dementia: a large prospective cohort study
Physical frailty and genetic factors are both risk factors for increased dementia; nevertheless, the joint effect remains unclear. This study aimed to investigated the long-term relationship between physical f...
-
Article
Open AccessCirc-0075305 hinders gastric cancer stem cells by indirectly disrupting TCF4–β-catenin complex and downregulation of SOX9
CircRNAs are covalently closed, single-stranded RNA that form continuous loops and play a crucial role in the initiation and progression of tumors. Cancer stem cells (CSCs) are indispensable for cancer develop...
-
Article
Metagenomic analysis of individual mosquito viromes reveals the geographical patterns and drivers of viral diversity
Mosquito transmitted viruses are responsible for an increasing burden of human disease. Despite this, little is known about the diversity and ecology of viruses within individual mosquito hosts. Here, using a ...
-
Article
Open AccessStructural mechanism of voltage-gated sodium channel slow inactivation
Voltage-gated sodium (NaV) channels mediate a plethora of electrical activities. NaV channels govern cellular excitability in response to depolarizing stimuli. Inactivation is an intrinsic property of NaV channel...
-
Article
Defining the land use area threshold and optimizing its structure to improve supply-demand balance state of ecosystem services
Improving the supply-demand balance of ecosystem services (SDBES) from the perspective of land use is essential for managing regional ecosystem and realizing sustainable development. By combining land use with...
-
Article
Load transfer mechanism of geotextile-reinforced sand layer over semirigid column-improved soft soil
Many design guidelines have been proposed for piled embankments, most of which consider piles or columns as rigid inclusions. In this study, a small-scale physical model test was performed to investigate the l...
-
Article
Open AccessAltered mucosal bacteria and metabolomics in patients with Peutz–Jeghers syndrome
Peutz–Jeghers syndrome (PJS) is a rare genetic disorder characterized by the development of pigmented spots, gastrointestinal polyps and increased susceptibility to cancers. Currently, most studies have invest...
