12,475 Result(s)

Article

Water-Soluble Se-Containing Proteins from Chicken Alleviate DSS-Induced Ulcerative Colitis in Mice via Inhibiting TLR4/MyD88 Pathway and Protecting the Goblet Cell Pathway

The influence of water-soluble selenium-containing proteins (WSSeP) in chicken on ulcerative colitis (UC) is not known. This work aims to investigate the effect of two WSSeP including h-Se with 1.78 μg Se/g an...

Yuancheng Li, Yanlong Xu, **n Hu, Chenxi Li, Lulu Wei… in Biological Trace Element Research (2024)

Article

Combination of Selenite and Butyrate Enhances Efficacy Against Colon Cancer by Targeting ASCT2-Mediated Amino Acid Metabolism

Drug combination is considered to be an effective approach to improve the efficacy of cancer therapy and chemoprevention. Selenite, a representative of inorganic form of selenium, and butyrate, a major short-c...

**ling Cui, **gsi Li, Shuang Zhao, Lihong Fan… in Biological Trace Element Research (2024)

Article

FEZF2 inhibits the growth of triple-negative breast cancer cells through EZH2/PD-L1 and enhances anti-tumor immunity in vivo

Triple-negative breast cancer (TNBC) is characterized by high aggressiveness, heterogeneity, and poor prognosis. Programmed cell death 1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors, a crucial type of i...

Wenyu Li, Hu Liu, Wenjuan Li, Qiujun Zhang, Qianyu Zhang… in Molecular & Cellular Toxicology (2024)

Article

Analysis of the droplet size and distribution for micro-sprinkling hose based on the LPM

A micro-sprinkling hose is promising water-saving irrigation equipment due to its low cost and ease of installation and dismantlement during operation. The performance of the micro-sprinkling hose depends on t...

Wenjuan Wang, Hui Wang, Shilei Wang, Wene Wang, Mingyu Hu, **aotao Hu in Irrigation Science (2024)

Article

YTHDC1 inhibits cell proliferation and angiogenesis in cervical cancer by regulating m6A modification of SOCS4 mRNA

Cervical cancer (CC) is one of the most common tumors in women, with a high mortality rate. YTHDC1 has been discovered to be involved in the progression of several cancers by acting as a tumor suppressor. Howe...

Sihe Chen, Yongheng Chen, Lanting Yu, **angmei Hu in Molecular & Cellular Toxicology (2024)

Article

GCGR: novel potential therapeutic target for chronic kidney disease

Yan Hu, Hao Huang, Rong **ang in Science China Life Sciences (2024)

Article

Nickel Induces Pyroptosis via the Nrf2/NLRP3 Pathway in Kidney of Mice

Nickel (Ni) is considered a toxic metal, and excessive exposure can cause kidney damage. This study was designed to explore whether nickel chloride (NiCl₂) can induce cell pyroptosis and its possible mechanism. H...

**g Li, **aoyu Dai, Shide Hu, Qiaolan Yang… in Biological Trace Element Research (2024)

Article

Hi-TOM 2.0: an improved platform for high-throughput mutation detection

Tingting Sun, Qing Liu, ** Chen, Fengyue Hu, Kejian Wang in Science China Life Sciences (2024)

Article

Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor

Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, ...

Luo-Yuan **a, Xue-Feng Wang, **ao-Ming Cui, Yi-Ming Zhang… in Science China Life Sciences (2024)

Article

Plant regeneration in the new era: from molecular mechanisms to biotechnology applications

Plants or tissues can be regenerated through various pathways. Like animal regeneration, cell totipotency and pluripotency are the molecular basis of plant regeneration. Detailed systematic studies on Arabidopsis...

Chunli Chen, Yuxin Hu, Momoko Ikeuchi, Yuling Jiao… in Science China Life Sciences (2024)

Article

Association Between Circulating Zinc Levels and Risk Factors of Metabolic Syndrome: Insights from a Bi-directional Mendelian Randomization Analysis and Cross-Sectional Study

Previous studies on the relationship between zinc and metabolic syndrome (MetS) have yielded inconsistent results. This comprehensive study aimed to elaborately explore the impact of zinc on MetS risk factors....

Yuanyuan Wu, Guoqiong Xu, Ruixue Bai, **** Yu… in Biological Trace Element Research (2024)

Article

Pioglitazone ameliorates ischemia/reperfusion-induced acute kidney injury via oxidative stress attenuation and NLRP3 inflammasome

Acute kidney injury (AKI) induced by renal ischemia/reperfusion injury (IRI) is a severe clinical condition. ROS accumulation, antioxidant pathways deficiency, and inflammation are involved in IRI. Pioglitazon...

Zhenfeng Ye, **g Zhang, Zhou Xu, Zhangwang Li, Gaomin Huang, Bin Tong… in Human Cell (2024)

Article

The key role of myostatin b in somatic growth in fishes derived from distant hybridization

The basic mechanism of heterosis has not been systematically and completely characterized. In previous studies, we obtained three economically important fishes that exhibit rapid growth, WR (WCC ♀ × RCC ♂), WR...

Qingfeng Liu, Lujiao Duan, Bei Li, Xuanyi Zhang, Fanglei Liu… in Science China Life Sciences (2024)

Article

Integrated multi-omics analysis and machine learning to refine molecular subtypes, prognosis, and immunotherapy in lung adenocarcinoma

Lung adenocarcinoma (LUAD) has a malignant characteristic that is highly aggressive and prone to metastasis. There is still a lack of suitable biomarkers to facilitate the refinement of precision-based therape...

Tao Han, Ying Bai, Yafeng Liu, Yunjia Dong, Chao Liang… in Functional & Integrative Genomics (2024)

Article

Responses of Rice Photosynthesis and Yield to Elevated CO₂ Concentrations: A Quantitative Analysis via Chlorophyll Fluorescence Technology

Scientific evidence indicates that elevated atmospheric CO₂ concentrations (e[CO₂]) have a significant impact on rice production. Further systematic exploration is necessary to understand the effects of e[CO₂] on...

Hao He, Chao Liu, Zhurong Wu, Mingjie Chen… in Journal of Soil Science and Plant Nutrition (2024)