26 Result(s)
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Biomedicine
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Article
Design of a total wrist prosthesis
Diseased wrist joints, in such cases as rheumatoid arthritis, are often required to be replaced by a prosthesis to relieve pain and to recover the wrist function.
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Article
Structural stiffness of the hoffmann simple anterior tibial external fixation frame
Tibial external fixation frames were constructed on aluminum tube simulating tibia bone. A 20-mm gap was left at the fracture site in order to measure the structural stiffness of the frame rather than the alum...
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Article
Blockade of HERG channels expressed in Xenopus oocytes by external H+
We have investigated the effect of external H+ concentration ([H+]o)on the human-ether-a-go-go-related gene (HERG) current (I HERG), the molecular equivalent of the cardiac delayed rectifier potassium current (I
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Article
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Obesity is generally considered an inflammatory state. Vishwa Dixit and his colleagues have now shown that excess dietary lipids leads to the activation of the Nlrp3 inflammasome, a sensor of the innate immune...
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Article
The angiotensin receptor blocker and PPAR-γ agonist, telmisartan, delays inactivation of voltage-gated sodium channel in rat heart: novel mechanism of drug action
Telmisartan is an angiotensin II receptor blocker and partial peroxisome proliferator-activated receptor gamma agonist that modulates the renin–angiotensin–aldosterone system. It is used primarily to manage hy...
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Article
Non-genomic effect of glucocorticoids on cardiovascular system
Glucocorticoids (GCs) are essential steroid hormones for homeostasis, development, metabolism, and cognition and possess anti-inflammatory and immunosuppressive actions. Since glucocorticoid receptor II (GR) i...
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Protocol
Quantification of Adipose Tissue Leukocytosis in Obesity
The infiltration of immune cell subsets in adipose tissue termed “adipose tissue leukocytosis” is a critical event in the development of chronic inflammation and obesity-associated comorbidities. Given that a ...
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Article
Class 3 inhibition of hERG K+ channel by caffeic acid phenethyl ester (CAPE) and curcumin
Human ether-á-go-go-related gene (hERG) K+ channel current (I hERG ) is inhibited by various compounds and genetic mutations, potentially resulting in cardiac ar...
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Article
Open AccessCombination treatment with 2-methoxyestradiol overcomes bortezomib resistance of multiple myeloma cells
Bortezomib is a proteasome inhibitor used for the treatment of relapsed/refractory multiple myeloma (MM). However, intrinsic and acquired resistance to bortezomib has already been observed in MM patients. In a...
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Article
A KCNQ1 mutation causes age-dependant bradycardia and persistent atrial fibrillation
Atrial fibrillation (AF) is the most common arrhythmia. Gain-of-function mutations in KCNQ1, the pore-forming α-subunit of the slow delayed rectifier K current (I Ks) channel, have been associated...
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Article
Influence of Surface Chemistry on Cytotoxicity and Cellular Uptake of Nanocapsules in Breast Cancer and Phagocytic Cells
The present work tests the hypothesis that stabilizers have a critical role on nanocarrier stealthiness and anticancer drug efficacy. Two different types of docetaxel (Doc)-loaded nanocapsules (NCs) stabilized...
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Article
Uptake and Cytotoxicity of Docetaxel-Loaded Hyaluronic Acid-Grafted Oily Core Nanocapsules in MDA-MB 231 Cancer Cells
It is hypothesized that docetaxel (Doc)-loaded hyaluronic acid (HA)-polyethylene glycol/poly(ε-caprolactone)-grafted oily core nanocapsules (NCs) can enhance the drug cytotoxicity and uptake in CD44 expressing...
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Article
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
Ketone bodies are elevated in response to fasting, a low-carbohydrate ketogenic diet or high-intensity exercise. Vishwa Deep Dixit and colleagues report that one metabolite, β-hydroxybutyrate, inhibits the NLR...
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Article
Open AccessIdentifying a low-risk group for parametrial involvement in microscopic Stage IB1 cervical cancer using criteria from ongoing studies and a new MRI criterion
There are currently three ongoing studies on less radical surgery in cervical cancer: ConCerv, GOG-278, and SHAPE. The aim of this study was to evaluate the performance of the criteria used in ongoing studies ...
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Article
Effects of streptozotocin and unilateral nephrectomy on L-type Ca2+ channels and membrane capacitance in arteriolar smooth muscle cells
Diabetes mellitus and hypertension are common diseases frequently coexisting. Although augmentation of L-type Ca2+ channel (ICaL) activity has been reported in vascular smooth muscle cells (VSMCs) of a spontaneou...
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Article
Echinochrome A regulates phosphorylation of phospholamban Ser16 and Thr17 suppressing cardiac SERCA2A Ca2+ reuptake
Echinochrome A (Ech A), a marine bio-product isolated from sea urchin eggs, is known to have cardioprotective effects through its strong antioxidant and ATP-sparing capabilities. However, the effects of Ech A ...
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Article
Spontaneous inward currents reflecting oscillatory activation of Na+/Ca2+ exchangers in human embryonic stem cell-derived cardiomyocytes
Na+/Ca2+ exchanger current (INCX) triggered by spontaneous Ca2+ release from sarcoplasmic reticulum (SR) has been suggested as one of the cardiac pacemaker mechanisms (“Ca2+ clock model”). In human embryonic stem...
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Article
Erratum to: Spontaneous inward currents reflecting oscillatory activation of Na+/Ca2+ exchangers in human embryonic stem cell-derived cardiomyocytes
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Article
Open AccessMitochondrial pyruvate dehydrogenase phosphatase 1 regulates the early differentiation of cardiomyocytes from mouse embryonic stem cells
Mitochondria are crucial for maintaining the properties of embryonic stem cells (ESCs) and for regulating their subsequent differentiation into diverse cell lineages, including cardiomyocytes. However, mitocho...
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Article
Open AccessCardiac inotropy, lusitropy, and Ca2+ handling with major metabolic substrates in rat heart
Fatty acid (FA)-dependent oxidation is the predominant process for energy supply in normal heart. Impaired FA metabolism and metabolic insufficiency underlie the failing of the myocardium. So far, FA metabolis...
