12 Result(s)
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**a Youm
Biomedicine
Human Physiology
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Article
Circadian modulation of the cardiac proteome underpins differential adaptation to morning and evening exercise training: an LC-MS/MS analysis
All living beings on earth are influenced by the circadian rhythm, the rising and the setting of the sun. The ubiquitous effect of exercise is widely believed to maximize health benefits but has not been forma...
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Resistance exercise improves cardiac function and mitochondrial efficiency in diabetic rat hearts
Metabolic disturbance and mitochondrial dysfunction are a hallmark of diabetic cardiomyopathy (DC). Resistance exercise (RE) not only enhances the condition of healthy individuals but could also improve the st...
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Article
Open AccessCardiac inotropy, lusitropy, and Ca2+ handling with major metabolic substrates in rat heart
Fatty acid (FA)-dependent oxidation is the predominant process for energy supply in normal heart. Impaired FA metabolism and metabolic insufficiency underlie the failing of the myocardium. So far, FA metabolis...
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Erratum to: Spontaneous inward currents reflecting oscillatory activation of Na+/Ca2+ exchangers in human embryonic stem cell-derived cardiomyocytes
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Article
Spontaneous inward currents reflecting oscillatory activation of Na+/Ca2+ exchangers in human embryonic stem cell-derived cardiomyocytes
Na+/Ca2+ exchanger current (INCX) triggered by spontaneous Ca2+ release from sarcoplasmic reticulum (SR) has been suggested as one of the cardiac pacemaker mechanisms (“Ca2+ clock model”). In human embryonic stem...
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Echinochrome A regulates phosphorylation of phospholamban Ser16 and Thr17 suppressing cardiac SERCA2A Ca2+ reuptake
Echinochrome A (Ech A), a marine bio-product isolated from sea urchin eggs, is known to have cardioprotective effects through its strong antioxidant and ATP-sparing capabilities. However, the effects of Ech A ...
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Article
Effects of streptozotocin and unilateral nephrectomy on L-type Ca2+ channels and membrane capacitance in arteriolar smooth muscle cells
Diabetes mellitus and hypertension are common diseases frequently coexisting. Although augmentation of L-type Ca2+ channel (ICaL) activity has been reported in vascular smooth muscle cells (VSMCs) of a spontaneou...
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A KCNQ1 mutation causes age-dependant bradycardia and persistent atrial fibrillation
Atrial fibrillation (AF) is the most common arrhythmia. Gain-of-function mutations in KCNQ1, the pore-forming α-subunit of the slow delayed rectifier K current (I Ks) channel, have been associated...
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Class 3 inhibition of hERG K+ channel by caffeic acid phenethyl ester (CAPE) and curcumin
Human ether-á-go-go-related gene (hERG) K+ channel current (I hERG ) is inhibited by various compounds and genetic mutations, potentially resulting in cardiac ar...
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Article
The angiotensin receptor blocker and PPAR-γ agonist, telmisartan, delays inactivation of voltage-gated sodium channel in rat heart: novel mechanism of drug action
Telmisartan is an angiotensin II receptor blocker and partial peroxisome proliferator-activated receptor gamma agonist that modulates the renin–angiotensin–aldosterone system. It is used primarily to manage hy...
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Article
Non-genomic effect of glucocorticoids on cardiovascular system
Glucocorticoids (GCs) are essential steroid hormones for homeostasis, development, metabolism, and cognition and possess anti-inflammatory and immunosuppressive actions. Since glucocorticoid receptor II (GR) i...
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Blockade of HERG channels expressed in Xenopus oocytes by external H+
We have investigated the effect of external H+ concentration ([H+]o)on the human-ether-a-go-go-related gene (HERG) current (I HERG), the molecular equivalent of the cardiac delayed rectifier potassium current (I
