26 Result(s)
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Biomedicine
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Article
Open AccessTomatidine-stimulated maturation of human embryonic stem cell-derived cardiomyocytes for modeling mitochondrial dysfunction
Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) have been reported to exhibit immature embryonic or fetal cardiomyocyte-like phenotypes. To enhance the maturation of hESC-CMs, we identified a natur...
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Open AccessClassification of Parkinson’s disease with freezing of gait based on 360° turning analysis using 36 kinematic features
Freezing of gait (FOG) is a sensitive problem, which is caused by motor control deficits and requires greater attention during postural transitions such as turning in people with Parkinson’s disease (PD). Howe...
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Article
Circadian modulation of the cardiac proteome underpins differential adaptation to morning and evening exercise training: an LC-MS/MS analysis
All living beings on earth are influenced by the circadian rhythm, the rising and the setting of the sun. The ubiquitous effect of exercise is widely believed to maximize health benefits but has not been forma...
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Open AccessValidity of shoe-type inertial measurement units for Parkinson’s disease patients during treadmill walking
When examining participants with pathologies, a shoe-type inertial measurement unit (IMU) system with sensors mounted on both the left and right outsoles may be more useful for analysis and provide better stab...
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Article
Resistance exercise improves cardiac function and mitochondrial efficiency in diabetic rat hearts
Metabolic disturbance and mitochondrial dysfunction are a hallmark of diabetic cardiomyopathy (DC). Resistance exercise (RE) not only enhances the condition of healthy individuals but could also improve the st...
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Advances in Targeted Drug Delivery Approaches for the Central Nervous System Tumors: The Inspiration of Nanobiotechnology
At present, brain tumor is among the most challenging diseases to treat and the therapy is limited by the lack of effective methods to deliver anticancer agents across the blood-brain barrier (BBB). BBB is a s...
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Open AccessCardiac inotropy, lusitropy, and Ca2+ handling with major metabolic substrates in rat heart
Fatty acid (FA)-dependent oxidation is the predominant process for energy supply in normal heart. Impaired FA metabolism and metabolic insufficiency underlie the failing of the myocardium. So far, FA metabolis...
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Article
Open AccessMitochondrial pyruvate dehydrogenase phosphatase 1 regulates the early differentiation of cardiomyocytes from mouse embryonic stem cells
Mitochondria are crucial for maintaining the properties of embryonic stem cells (ESCs) and for regulating their subsequent differentiation into diverse cell lineages, including cardiomyocytes. However, mitocho...
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Erratum to: Spontaneous inward currents reflecting oscillatory activation of Na+/Ca2+ exchangers in human embryonic stem cell-derived cardiomyocytes
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Article
Spontaneous inward currents reflecting oscillatory activation of Na+/Ca2+ exchangers in human embryonic stem cell-derived cardiomyocytes
Na+/Ca2+ exchanger current (INCX) triggered by spontaneous Ca2+ release from sarcoplasmic reticulum (SR) has been suggested as one of the cardiac pacemaker mechanisms (“Ca2+ clock model”). In human embryonic stem...
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Article
Echinochrome A regulates phosphorylation of phospholamban Ser16 and Thr17 suppressing cardiac SERCA2A Ca2+ reuptake
Echinochrome A (Ech A), a marine bio-product isolated from sea urchin eggs, is known to have cardioprotective effects through its strong antioxidant and ATP-sparing capabilities. However, the effects of Ech A ...
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Article
Effects of streptozotocin and unilateral nephrectomy on L-type Ca2+ channels and membrane capacitance in arteriolar smooth muscle cells
Diabetes mellitus and hypertension are common diseases frequently coexisting. Although augmentation of L-type Ca2+ channel (ICaL) activity has been reported in vascular smooth muscle cells (VSMCs) of a spontaneou...
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Article
Open AccessIdentifying a low-risk group for parametrial involvement in microscopic Stage IB1 cervical cancer using criteria from ongoing studies and a new MRI criterion
There are currently three ongoing studies on less radical surgery in cervical cancer: ConCerv, GOG-278, and SHAPE. The aim of this study was to evaluate the performance of the criteria used in ongoing studies ...
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Article
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
Ketone bodies are elevated in response to fasting, a low-carbohydrate ketogenic diet or high-intensity exercise. Vishwa Deep Dixit and colleagues report that one metabolite, β-hydroxybutyrate, inhibits the NLR...
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Article
Uptake and Cytotoxicity of Docetaxel-Loaded Hyaluronic Acid-Grafted Oily Core Nanocapsules in MDA-MB 231 Cancer Cells
It is hypothesized that docetaxel (Doc)-loaded hyaluronic acid (HA)-polyethylene glycol/poly(ε-caprolactone)-grafted oily core nanocapsules (NCs) can enhance the drug cytotoxicity and uptake in CD44 expressing...
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Article
Influence of Surface Chemistry on Cytotoxicity and Cellular Uptake of Nanocapsules in Breast Cancer and Phagocytic Cells
The present work tests the hypothesis that stabilizers have a critical role on nanocarrier stealthiness and anticancer drug efficacy. Two different types of docetaxel (Doc)-loaded nanocapsules (NCs) stabilized...
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Article
A KCNQ1 mutation causes age-dependant bradycardia and persistent atrial fibrillation
Atrial fibrillation (AF) is the most common arrhythmia. Gain-of-function mutations in KCNQ1, the pore-forming α-subunit of the slow delayed rectifier K current (I Ks) channel, have been associated...
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Open AccessCombination treatment with 2-methoxyestradiol overcomes bortezomib resistance of multiple myeloma cells
Bortezomib is a proteasome inhibitor used for the treatment of relapsed/refractory multiple myeloma (MM). However, intrinsic and acquired resistance to bortezomib has already been observed in MM patients. In a...
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Article
Class 3 inhibition of hERG K+ channel by caffeic acid phenethyl ester (CAPE) and curcumin
Human ether-á-go-go-related gene (hERG) K+ channel current (I hERG ) is inhibited by various compounds and genetic mutations, potentially resulting in cardiac ar...
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Protocol
Quantification of Adipose Tissue Leukocytosis in Obesity
The infiltration of immune cell subsets in adipose tissue termed “adipose tissue leukocytosis” is a critical event in the development of chronic inflammation and obesity-associated comorbidities. Given that a ...
