89 Result(s)

Article

Nicotinate-curcumin improves NASH by inhibiting the AKR1B10/ACCα-mediated triglyceride synthesis

Nonalcoholic steatohepatitis (NASH) is a prevalent chronic liver condition. However, the potential therapeutic benefits and underlying mechanism of nicotinate-curcumin (NC) in the treatment of NASH remain unce...

**u-lian Lin, Ya-ling Zeng, Jie Ning, Zhe Cao, Lan-lan Bu… in Lipids in Health and Disease (2024)

Article

TMC6 functions as a GPCR-like receptor to sense noxious heat via Gαq signaling

Thermosensation is vital for the survival, propagation, and adaption of all organisms, but its mechanism is not fully understood yet. Here, we find that TMC6, a membrane protein of unknown function, is highly ...

Chen Zhang, Fang Tong, Bin Zhou, Mingdong He, Shuai Liu, **aomeng Zhou… in Cell Discovery (2024)

Article

PE/PPE mutations in the transmission of Mycobacterium tuberculosis in China revealed by whole genome sequencing

This study aims to examine the impact of PE/PPE gene mutations on the transmission of Mycobacterium tuberculosis (M. tuberculosis) in China.

Wei-wei Fang, **ang-long Kong, Jie-yu Yang, Ning-ning Tao, Ya-meng Li… in BMC Microbiology (2024)

Article

Genome-wide identification and expression analysis of the KNOX family and its diverse roles in response to growth and abiotic tolerance in sweet potato and its two diploid relatives

KNOXs, a type of homeobox genes that encode atypical homeobox proteins, play an essential role in the regulation of growth and development, hormonal response, and abiotic stress in plants. However, the KNOX gene ...

Li-Cong Jia, Zi-Tong Yang, Li-Li Shang, Shao-Zhen He, Huan Zhang, Xu Li… in BMC Genomics (2024)

Article

Author Correction: Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy

Ya-Nan Qiao, Lei Li, Song-Hua Hu, Yuan-**n Yang, Zhen-Zhen Ma, Lin Huang… in Cell Discovery (2024)

Article

Thrombomodulin reduces α-synuclein generation and ameliorates neuropathology in a mouse model of Parkinson’s disease

The neurotoxic α-synuclein (α-syn) oligomers play an important role in the occurrence and development of Parkinson’s disease (PD), but the factors affecting α-syn generation and neurotoxicity remain unclear. W...

**ao-yun Niu, **-xiu **e, Hou-zhen Tuo, Cui-** Lv, Ya-ru Huang… in Cell Death Discovery (2024)

Article

Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model

Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate ...

Yang Fu, Yong-Song Chen, Dai-Yang **a, **ao-Dan Luo… in npj Biofilms and Microbiomes (2024)

Article

Advanced oxidation protein products attenuate the autophagy-lysosome pathway in ovarian granulosa cells by modulating the ROS-dependent mTOR-TFEB pathway

Oxidative stress dysfunction has recently been found to be involved in the pathogenesis of premature ovarian insufficiency (POI). Previously, we found that advanced oxidation protein products (AOPPs) in plasma...

**ng-Yu Zhou, Yun-Hui Lai, Jun Zhang, Ying Li, **ao-Min Wu… in Cell Death & Disease (2024)

Article

Ketogenic diet-produced β-hydroxybutyric acid accumulates brain GABA and increases GABA/glutamate ratio to inhibit epilepsy

Ketogenic diet (KD) alleviates refractory epilepsy and reduces seizures in children. However, the metabolic/cell biologic mechanisms by which the KD exerts its antiepileptic efficacy remain elusive. Herein, we...

Ya-Nan Qiao, Lei Li, Song-Hua Hu, Yuan-**n Yang, Zhen-Zhen Ma, Lin Huang… in Cell Discovery (2024)

Article

CIP2A induces PKM2 tetramer formation and oxidative phosphorylation in non-small cell lung cancer

Tumor cells are usually considered defective in mitochondrial respiration, but human non-small cell lung cancer (NSCLC) tumor tissues are shown to have enhanced glucose oxidation relative to adjacent benign lu...

Li-Jun Liang, Fu-Ying Yang, Di Wang, Yan-Fei Zhang, Hong Yu, Zheng Wang… in Cell Discovery (2024)

Article

Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel

Wenxuan Zhen, Zhijun Zhao, Shenghai Chang, **aoying Chen, Yangzhuoqun Wan… in Cell Discovery (2023)

Article

The mitochondrial protein TIMM44 is required for angiogenesis in vitro and in vivo

The mitochondrial integrity and function in endothelial cells are essential for angiogenesis. TIMM44 (translocase of inner mitochondrial membrane 44) is essential for integrity and function of mitochondria. He...

Zhou-rui Ma, Hong-Peng Li, Shi-zhong Cai, Sheng-Yang Du, **a Chen… in Cell Death & Disease (2023)

Article

Author Correction: Comprehensive characterization of three classes of Arabidopsis SWI/SNF chromatin remodelling complexes

**g Guo, Guang Cai, Yong-Qiang Li, Yi-Xuan Zhang, Yin-Na Su… in Nature Plants (2023)

Article

A novel microRNA-182/Interleukin-8 regulatory axis controls osteolytic bone metastasis of lung cancer

Bone metastasis is one of the main complications of lung cancer and most important factors that lead to poor life quality and low survival rate in lung cancer patients. However, the regulatory mechanisms under...

Ming-Na Zhao, Ling-Fei Zhang, Zhen Sun, Li-Hua Qiao, Tao Yang… in Cell Death & Disease (2023)

Article

TM4SF1 upregulates MYH9 to activate the NOTCH pathway to promote cancer stemness and lenvatinib resistance in HCC

TM4SF1, a member of the transmembrane 4 superfamily, is crucial for both healthy and malignant human tissues. The significant function of TM4SF1 in the incidence and progression of cancer has been widely recog...

Si-bo Yang, Zi-han Zhou, ** Lei, **ao-wen Li, Qian Chen, Bo Li… in Biology Direct (2023)

Article

Molecular and physiological mechanisms of tea (Camellia sinensis (L.) O. Kuntze) leaf and root in response to nitrogen deficiency

As an economically important crop, tea is strongly nitrogen (N)-dependent. However, the physiological and molecular mechanisms underlying the response of N deficiency in tea are not fully understood. Tea culti...

Zheng-He Lin, Chang-Song Chen, Shui-Qing Zhao, Yuan Liu, Qiu-Sheng Zhong… in BMC Genomics (2023)

Article

TMT-based quantitative proteomics analysis of the effects of Jiawei Danshen decoction myocardial ischemia-reperfusion injury

Every year, approximately 17 million people worldwide die due to coronary heart disease, with China ranking second in terms of the death toll. Myocardial ischemia-reperfusion injury (MIRI) significantly influe...

**ang-Mei Zhu, Yang Tan, Yu-He Shi, Qing Li, Jue Zhu, **ang-Dan Liu… in Proteome Science (2022)

Article

An IGF1-expressing endometrial stromal cell population is associated with human decidualization

Decidualization refers to the process of transformation of endometrial stromal fibroblast cells into specialized decidual stromal cells that provide a nutritive and immunoprivileged matrix essential for blasto...

Jia-Wei Shi, Zhen-Zhen Lai, Hui-Li Yang, Wen-Jie Zhou, **ao-Ya Zhao… in BMC Biology (2022)

Article

Correction: CRISPR FISHer enables high-sensitivity imaging of nonrepetitive DNA in living cells through phase separation-mediated signal amplification

**n-Yuan Lyu, Yuan Deng, **ao-Yan Huang, Zhen-Zhen Li, Guo-Qing Fang… in Cell Research (2022)

Article

Loss of function of CMPK2 causes mitochondria deficiency and brain calcification

Brain calcification is a critical aging-associated pathology and can cause multifaceted neurological symptoms. Cerebral phosphate homeostasis dysregulation, blood-brain barrier defects, and immune dysregulatio...

Miao Zhao, Hui-Zhen Su, Yi-Heng Zeng, Yuan Sun, **n-**n Guo, Yun-Lu Li… in Cell Discovery (2022)