42 Result(s)

Article

AAA237, an SKP2 inhibitor, suppresses glioblastoma by inducing BNIP3-dependent autophagy through the mTOR pathway

Glioblastoma (GBM) is the most common brain tumor with the worst prognosis. Temozolomide is the only first-line drug for GBM. Unfortunately, the resistance issue is a classic problem. Therefore, it is essentia...

Yizhi Zhang, Wan Li, Yihui Yang, Sen Zhang, Hong Yang, Yue Hao… in Cancer Cell International (2024)

Article

Cuproptosis related gene PDHB is identified as a biomarker inversely associated with the progression of clear cell renal cell carcinoma

Cuproptosis is a newly discovered programmed cell death dependent on mitochondrial respiratory disorder induced by copper overload. Pyruvate dehydrogenase E1 subunit beta (PDHB) is one of the cuproptosis genes...

Hu Wang, Zhan Yang, **ngyu He, Fengran Guo, Hao Sun, Sen Xu, Chao Xu… in BMC Cancer (2023)

Article

Targeting a vulnerable septum-hippocampus cholinergic circuit in a critical time window ameliorates tau-impaired memory consolidation

Abnormal tau accumulation and cholinergic degeneration are hallmark pathologies in the brains of patients with Alzheimer’s disease (AD). However, the sensitivity of cholinergic neurons to AD-like tau accumulat...

Dongqin Wu, Nana Yu, Yang Gao, Rui **ong, Lu** Liu… in Molecular Neurodegeneration (2023)

Article

Association of novel and conventional obesity indices with colorectal cancer risk in older Chinese: a 14-year follow-up of the Guangzhou Biobank Cohort Study

Visceral adiposity index (VAI) and a body shape index (ABSI) were newly developed indices for visceral fat mass. Whether they are superior to conventional obesity indices in predicting colorectal cancer (CRC) ...

Shu Yi Wang, Wei Sen Zhang, Chao Qiang Jiang, Ya Li **, Tong Zhu, Feng Zhu… in BMC Cancer (2023)

Article

Effects of non-invasive brain stimulation on motor function after spinal cord injury: a systematic review and meta-analysis

In recent years, non-invasive brain stimulation (NIBS) has been used for motor function recovery. However, the effects of NIBS in populations with spinal cord injury (SCI) remain unclear. This study aims to co...

Jian-Min Chen, **ao-Lu Li, Qin-He Pan… in Journal of NeuroEngineering and Rehabilita… (2023)

Article

Identification of TARDBP Gly298Ser as a founder mutation for amyotrophic lateral sclerosis in Southern China

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by predominant impairment of upper and lower motor neurons. Over 50 TARDBP mutations have been reported in both familia...

Fanxi Xu, Sen Huang, Xu-Ying Li, Jianing Lin, **uli Feng, Shu **e… in BMC Medical Genomics (2022)

Article

PLXDC2 enhances invadopodium formation to promote invasion and metastasis of gastric cancer cells via interacting with PTP1B

Plexin-domain containing 2 (PLXDC2) has been reported as an oncoprotein in several human malignancies. However, its expression and roles in gastric cancer remain largely unclear. In this study, we found that P...

Bin Wu, Yan-xia Wang, Jun-jie Wang, Dong-fang **ang… in Clinical & Experimental Metastasis (2022)

Article

Amelioration of Alzheimer’s disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow

A reduced removal of dysfunctional mitochondria is common to aging and age-related neurodegenerative pathologies such as Alzheimer’s disease (AD). Strategies for treating such impaired mitophagy would benefit ...

Chenglong **e, Xu-Xu Zhuang, Zhangming Niu, Ruixue Ai… in Nature Biomedical Engineering (2022)

Article

Development and validation of a radiomics-based model to predict local progression-free survival after chemo-radiotherapy in patients with esophageal squamous cell cancer

To develop a nomogram model for predicting local progress-free survival (LPFS) in esophageal squamous cell carcinoma (ESCC) patients treated with concurrent chemo-radiotherapy (CCRT).

He-San Luo, Ying-Ying Chen, Wei-Zhen Huang, Sheng-** Wu… in Radiation Oncology (2021)

Article

RETRACTED ARTICLE: Astrocytes Regulate Differentiation and Glutamate Uptake of Glioma Stem Cells via Formyl Peptide Receptor

Ya-Wen Xu, **-Shan Yang, De-Zhi Kang, Pei-Sen Yao in Cellular and Molecular Neurobiology (2021)

Article

CircFAM73A promotes the cancer stem cell-like properties of gastric cancer through the miR-490-3p/HMGA2 positive feedback loop and HNRNPK-mediated β-catenin stabilization

Circular RNAs (circRNAs) have emerged as a new subclass of regulatory RNAs that play critical roles in various cancers. Cancer stem cells (CSCs), a small subset of cancer cells, are believed to possess the cap...

Yiwen **a, Jialun Lv, Tianlu Jiang, Bowen Li… in Journal of Experimental & Clinical Cancer … (2021)

Article

Genome-wide cell-free DNA methylation analyses improve accuracy of non-invasive diagnostic imaging for early-stage breast cancer

Early detection is crucial to improve breast cancer (BC) patients’ outcomes and survival. Mammogram and ultrasound adopting the Breast Imaging Reporting and Data System (BI-RADS) categorization are widely used...

Jiaqi Liu, Hengqiang Zhao, Yukuan Huang, Shou** Xu, Yan Zhou… in Molecular Cancer (2021)

Article

HDAC2 inhibits EMT-mediated cancer metastasis by downregulating the long noncoding RNA H19 in colorectal cancer

Emerging evidence suggests that epithelial mesenchymal transition (EMT) and epigenetic mechanisms promote metastasis. Histone deacetylases (HDACs) and noncoding RNAs (ncRNAs) are important epigenetic regulators. ...

Xue-ting Hu, Wei **ng, Rong-sen Zhao… in Journal of Experimental & Clinical Cancer … (2020)

Article

Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression

Cisplatin (CDDP) is the first-line chemotherapy for gastric cancer (GC). The poor prognosis of GC patients is partially due to the development of CDDP resistance. Circular RNAs (circRNAs) are a subclass of non...

Guangli Sun, Zheng Li, Zhongyuan He… in Journal of Experimental & Clinical Cancer … (2020)

Article

p63⁺Krt5⁺ basal cells are increased in the squamous metaplastic epithelium of patients with radiation-induced chronic Rhinosinusitis

Squamous metaplasia (SM) is an irreversible form of airway epithelial remodeling. Hyperproliferation of basal cells was observed in squamous metaplastic epithelium of chronically inflamed airway. However, the ...

Hongming Huang, Kai Sen Tan, Suizi Zhou, Tian Yuan, **g Liu… in Radiation Oncology (2020)

Article

High-brightness anterograde transneuronal HSV1 H129 tracer modified using a Trojan horse-like strategy

Neurotropic viral transsynaptic tracing is an increasingly powerful technique for dissecting the structure and function of neural circuits. Herpes simplex virus type 1 strain H129 has been widely used as an an...

Peng Su, Min Ying, Zengpeng Han, **** **a, Sen **, Yingli Li… in Molecular Brain (2020)

Article

Impact of sex on the prognosis of patients with esophageal squamous cell cancer underwent definitive radiotherapy: a propensity score-matched analysis

The impact of sex on prognosis of patients with esophageal squamous cell cancer (ESCC) who underwent definitive radiotherapy remained unclear. The present study aimed to determine the impact of sex on the prog...

He-San Luo, Hong-Yao Xu, Ze-Sen Du, Xu-Yuan Li, Sheng-** Wu… in Radiation Oncology (2019)

Article

Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression

Cisplatin (CDDP) treatment is one of the most predominant chemotherapeutic strategies for patients with gastric cancer (GC). A better understanding of the mechanisms of CDDP resistance can greatly improve ther...

**aoxu Huang, Zheng Li, Qiang Zhang, Weizhi Wang, Bowen Li, Lu Wang… in Molecular Cancer (2019)

Article

Development and In Vivo Evaluation of Ziyuglycoside I–Loaded Self-Microemulsifying Formulation for Activity of Increasing Leukocyte

Ziyuglycoside I (ZgI), a major effective ingredient of Sanguisorba officinalis L, has shown good activity in increasing leukocyte of myelosuppression mice. However, oral ZgI therapy has been deterred by poor bioa...

Yongai **ong, Ya Zou, Li Chen, Yingshu Xu, Sen Wang in AAPS PharmSciTech (2019)

Article

Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway

CircRNA has emerged as a new non-coding RNA that plays crucial roles in tumour initiation and development. ‘MiRNA sponge’ is the most reported role played by circRNAs in many tumours. The AKT/mTOR axis is a cl...

**ng Zhang, Sen Wang, Haixiao Wang, Jiacheng Cao, **aoxu Huang… in Molecular Cancer (2019)