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**-ming Li
Oncology
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Article
Different effects of selenium on cyclic AMP metabolism in hepatoma cells and normal liver cells
Sodium selenite administered to normal and hepatoma (HA)-bearing mice sc (2 mg/kg) or ip (1 mg/kg) led to a significant increase in cyclic AMP (cAMP) level and a decrease in cAMP phosphodiesterase (PDE) activi...
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Abstracts
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Article
Selenium effects on camp metabolism in hepatoma cells and normal liver cells
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Chapter
Etiology of Carcinoma of the Esophagus
In recent years considerable progress has been made in research into the etiologic factors of esophageal cancer. The most striking feature of the distribution of this cancer is the existence of high-risk areas...
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Stimulation of cell growth ofTetrahymena pyriformis andChlamydomonas reinhardtii by trace elements
Tetrahymena pyriformis, S1 andBJ11, andChlamydomonas reinhardtii CR were employed to study the stimulation of cell proliferation induced by a number of elements. It was observed that traces of Ga, As, Se, Rb, Sr,...
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Article
The effect of ara-C-induced inhibition of DNA synthesis on its cellular pharmacology
The cytotoxicity of ara-C is believed to result from incorporation of ara-CTP into DNA and inhibition of DNA synthesis. Since complete inhibition of DNA synthesis would prevent further incorporation of ara-CTP...
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Interaction between endotoxin and the antitumour agent 5,6-dimethylxanthenone-4-acetic acid in the induction of tumour necrosis factor and haemorrhagic necrosis of colon 38 tumours
The investigational antitumour agent 5,6-dimethyl-xanthenone-4-acetic acid (5,6-MeXAA) induced dosedependent haemorrhagic necrosis of colon 38 tumours to a similar extent to that induced using bacterial lipopo...
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Combination chemotherapy with carmustine and cisplatin before, during, and after radiotherapy for adult malignant gliomas
Twenty-two patients, aged 16 to 67, who had malignant gliomas after surgical resection were treated with carmustine and cisplatin intravenous infusion before, during, and after radiotherapy. All patients had s...
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High seroprevalence of IgG againstHelicobacter pylori among endoscopists in Taiwan
A prospective survey to investigate the seroprevalence of IgG againstHelicobacter pylori among endoscopists in Taiwan was conducted by analyzing blood samples of 70 study subjects and 64 nonendoscopist physicians...
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Evaluation of in vitro chemosensitivity of antitumor drugs using the MTT assay in fresh human breast cancer
Practical criteria were developed in this paper for the purpose of evaluating chemosensitivity of fresh human breast cancer by the MTT assay. The survival rates at maximum inhibition (Imax %) and the concentra...
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Predictive chemotherapy of advanced breast cancer directed by MTT assay in vitro
In order to investigate the predictive value of in vitro MTT assay for directing chemotherapy of breast cancer patients, from 1992 to 1995, 156 advanced breast cancer patients who had evaluable lesions were re...
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Topoisomerase I and II Activity Assays
DNA topoisomerases I and II (top1 and top2, respectively) are ubiquitous enzymes that play an essential role in transcription, replication, chromosome segregation, and DNA repair. The basic enzymatic reaction ...
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High frequency of p16INK4A gene alterations in hepatocellular carcinoma
The tumor suppressor gene p16 (CDKN2/MTS-1/INK4A) is an important component of the cell cycle and inactivation of the gene has been found in a variety of human cancers. In order to investigate the role of p16 ...
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Neo-adjuvant chemotherapy for operable breast cancer induces apoptosis
The use of neo-adjuvant chemotherapy (often referred to as pre-operative or primary chemotherapy) represents a major change in the management of breast cancer as a systemic disease. Laboratory studies have sho...
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Microvessel density of hepatocellular carcinoma: its relationship with prognosis
Purpose: To elucidate the relationship between angiogenesis and prognosis after curative resection of hepatocellular carcinoma (HCC). Methods: An immunohistochemical study using anti-CD34 monoclonal antibody was...
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Expression of platelet-derived endothelial cell growth factor and vascular endothelial growth factor in hepatocellular carcinoma and portal vein tumor thrombus
Purpose: Both platelet-derived endothelial cell growth factor (PD-ECGF) and vascular endothelial growth factor (VEGF) are known to promote the development of new blood vessels, which are fundamental to tumor gro...
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Effects of the serotonin receptor antagonist cyproheptadine on the activity and pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
Background: DMXAA (5,6-dimethylxanthenone-4-acetic acid) is a new drug synthesized in this laboratory and currently in phase I clinical trial. In mice it acts as an antivascular drug, selectively inhibiting tumo...
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Article
Structural alterations of sugar chains in urine fibronectin from bladder cancer patients and its enzymatic mechanism
Purpose: To study the structural alterations of asparagine-linked sugar chains (N-glycans) on urine fibronectin (Fn) from bladder cancer (BCa) patients and its enzymatic mechanism. Methods: Eight pairs of urine ...
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Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G2/M arrest or apoptosis
The lats gene encodes a family of proteins conserved from insects to humans. Drosophila carrying lats mutant cells or mice deficient for Lats1 develop tumors in various tissues. The mammalian LATS1 protein was pr...
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Evidence that a burst of DNA depurination in SENCAR mouse skin induces error-prone repair and forms mutations in the H-ras gene
Treatment of SENCAR mouse skin with dibenzo[a,l]pyrene results in abundant formation of abasic sites that undergo error-prone excision repair, forming oncogenic H-ras mutations in the early preneoplastic period. ...
