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Open AccessChiral dinitrogen ligand enabled asymmetric Pd/norbornene cooperative catalysis toward the assembly of C–N axially chiral scaffolds
C − N axially chiral compounds have recently attracted significant interest among synthetic chemistry community due to their widespread application in pharmaceuticals, advanced materials and organic synthesis....
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Article
Open AccessSerum sex hormones correlate with pathological features of papillary thyroid cancer
Sex hormones are thought to be responsible for the unique gender differences in papillary thyroid cancer(PTC). Most previous studies on these have focused on the expression of estrogen receptors, or have been ...
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Open AccessA clinical study of non-bioartificial liver DPMAES support system in hepatitis B-related acute-on-chronic liver failure
This study aims to observe the clinical efficacy of the dual plasma molecular adsorption exchange system (DPMAES) in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF), with a fo...
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Open AccessMyeloid cells interact with a subset of thyrocytes to promote their migration and follicle formation through NF-κB
The pathogenesis of thyroid dysgenesis (TD) is not well understood. Here, using a combination of single-cell RNA and spatial transcriptome sequencing, we identify a subgroup of NF-κB-activated thyrocytes locat...
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Open AccessPrevalence and molecular characterization of Giardia duodenalis in dairy cattle in Central Inner Mongolia, Northern China
Giardia duodenalis is a gastrointestinal protozoan ubiquitous in nature. It is a confirmed zoonotic pathogen, and cattle are considered a source of giardiasis outbreaks in humans. This study aimed to evaluate the...
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Liver tumour immune microenvironment subtypes and neutrophil heterogeneity
The heterogeneity of the tumour immune microenvironment (TIME), organized by various immune and stromal cells, is a major contributing factor of tumour metastasis, relapse and drug resistance1–3, but how differen...
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Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency
Diabetes mellitus is prevalent among women of reproductive age, and many women are left undiagnosed or untreated1. Gestational diabetes has profound and enduring effects on the long-term health of the offspring2,
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Observing polymerization in 2D dynamic covalent polymers
The quality of crystalline two-dimensional (2D) polymers1–6 is intimately related to the elusive polymerization and crystallization processes. Understanding the mechanism of such processes at the (sub)molecular l...
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Open AccessStructural control of a novel hierarchical porous carbon material and its adsorption properties
Novel hierarchical porous carbon materials (HPCs) were fabricated via a reactive template-induced in situ hypercrosslinking procedure. The effects of carbonization conditions on the microstructure and morpholo...
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Global map** of crop-specific emission factors highlights hotspots of nitrous oxide mitigation
Mitigating soil nitrous oxide (N2O) emissions is essential for staying below a 2 °C warming threshold. However, accurate assessments of mitigation potential are limited by uncertainty and variability in direct em...
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Open AccessSubnanometer high-entropy alloy nanowires enable remarkable hydrogen oxidation catalysis
High-entropy alloys (HEAs) with unique physicochemical properties have attracted tremendous attention in many fields, yet the precise control on dimension and morphology at atomic level remains formidable chal...
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Open AccessRNA-seq profiling reveals PBMC RNA as a potential biomarker for hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors and has extremely high morbidity and mortality. Although many existing studies have focused on the identification of biomarkers, little...
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Open AccessManganese-mediated reductive functionalization of activated aliphatic acids and primary amines
Alkyl carboxylic acids as well as primary amines are ubiquitous in all facets of biological science, pharmaceutical science, chemical science and materials science. By chemical conversion to redox-active ester...
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Open AccessHigher-order quantum spin Hall effect in a photonic crystal
The quantum spin Hall effect lays the foundation for the topologically protected manipulation of waves, but is restricted to one-dimensional-lower boundaries of systems and hence limits the diversity and integ...
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Open AccessObserving atomic layer electrodeposition on single nanocrystals surface by dark field spectroscopy
Underpotential deposition offers a predominant way to tailor the electronic structure of the catalytic surface at the atomic level, which is key to engineering materials with a high activity for (electro)catal...
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Open AccessSymmetry-protected hierarchy of anomalous multipole topological band gaps in nonsymmorphic metacrystals
Symmetry and topology are two fundamental aspects of many quantum states of matter. Recently new topological materials, higher-order topological insulators, were discovered, featuring bulk–edge–corner correspo...
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Open AccessPreoperative Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio are Associated with the Prognosis of Group 3 and Group 4 Medulloblastoma
Inflammation and immunoreaction markers were correlated with the survival of patients in many tumors. However, there were no reports investigating the relationships between preoperative hematological markers a...
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Open AccessIdentification and characterization of the MADS-box genes highly expressed in the laticifer cells of Hevea brasiliensis
MADS-box transcription factors possess many functions in plant reproduction and development. However, few MADS-box genes related to secondary metabolites regulation have been identified. In Hevea brasiliensis, na...
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Open AccessLiver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases
Cardiovascular and metabolic disease (CMD) remains a main cause of premature death worldwide. Berberine (BBR), a lipid-lowering botanic compound with diversified potency against metabolic disorders, is a promi...
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Open AccessGmSYP24, a putative syntaxin gene, confers osmotic/drought, salt stress tolerances and ABA signal pathway
As major environment factors, drought or high salinity affect crop growth, development and yield. Transgenic approach is an effective way to improve abiotic stress tolerance of crops. In this study, we compara...