18 Result(s)

Article

Integrating genomic and multiomic data for Angelica sinensis provides insights into the evolution and biosynthesis of pharmaceutically bioactive compounds

Angelica sinensis roots (Angelica roots) are rich in many bioactive compounds, including phthalides, coumarins, lignans, and terpenoids. However, the molecular bases for their biosynthesis are still poorly unders...

Shiming Li, Tsan-Yu Chiu, **n **, Dong Cao, Meng Xu, Mingzhi Zhu… in Communications Biology (2023)

Article

Oncometabolite D-2-hydroxyglutarate—dependent metabolic reprogramming induces skeletal muscle atrophy during cancer cachexia

Cancer cachexia is characterized by weight loss and skeletal muscle wasting. Based on the up-regulation of catabolism and down-regulation of anabolism, here we showed genetic mutation-mediated metabolic reprog...

**nting Zhu, Juan Hao, Hong Zhang, Mengyi Chi, Yaxian Wang… in Communications Biology (2023)

Article

Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids

Studies of cultured embryos have provided insights into human peri-implantation development. However, detailed knowledge of peri-implantation lineage development as well as underlying mechanisms remains obscur...

Zongyong Ai, Baohua Niu, Yu Yin, Lifeng **ang, Gaohui Shi, Kui Duan… in Cell Research (2023)

Article

Differences in foot shape when wearing wedge-heeled shoes with elevated forefoot height and heel height

Wedge-heeled shoes, which are formed by elevating both the forefoot and heel, have been popular among young women. However, research on the foot shape in wedge-heeled shoes is lacking. This study aimed to acce...

Ao Zhu, Yu-Chi Lee in Fashion and Textiles (2023)

Article

Comparative genome anatomy reveals evolutionary insights into a unique amphitriploid fish

Triploids are rare in nature because of difficulties in meiotic and gametogenic processes, especially in vertebrates. The Carassius complex of cyprinid teleosts contains sexual tetraploid crucian carp/goldfish (C...

Yang Wang, **-Yin Li, Wen-Jie Xu, Kun Wang, Bin Wu, Meng Xu… in Nature Ecology & Evolution (2022)

Article

Osteocrin, a novel myokine, prevents diabetic cardiomyopathy via restoring proteasomal activity

Proteasomal activity is compromised in diabetic hearts that contributes to proteotoxic stresses and cardiac dysfunction. Osteocrin (OSTN) acts as a novel exercise-responsive myokine and is implicated in variou...

**n Zhang, Can Hu, **ao-Pin Yuan, Yu-Pei Yuan, Peng Song… in Cell Death & Disease (2021)

Article

CAMK2A supported tumor initiating cells of lung adenocarcinoma by upregulating SOX2 through EZH2 phosphorylation

Tumor initiating cells (TIC) of lung cancer are mainly induced by stress-related plasticity. Calcium/Calmodulin dependent protein kinase II alpha (CAMK2A) is a key calcium signaling molecule activated by exoge...

Si-Qi Wang, **g Liu, **g Qin, Yun Zhu, Vicky Pui-Chi Tin… in Cell Death & Disease (2020)

Article

FNDC5 alleviates oxidative stress and cardiomyocyte apoptosis in doxorubicin-induced cardiotoxicity via activating AKT

Oxidative stress and cardiomyocyte apoptosis play critical roles in doxorubicin (DOX)-induced cardiotoxicity. Previous studies indicated that fibronectin type III domain-containing 5 (FNDC5) and its cleaved fo...

**n Zhang, Can Hu, Chun-Yan Kong, Peng Song, Hai-Ming Wu… in Cell Death & Differentiation (2020)

Article

Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition

The response of endothelial cells to signaling stimulation is critical for vascular morphogenesis, homeostasis and function. Vascular endothelial growth factor-a (VEGFA) has been commonly recognized as a pro-a...

Wencao Zhao, Le Cao, Hanru Ying, Wenjuan Zhang, Dantong Li, **aolong Zhu… in Cell Research (2019)

Article

PPARα and PPARγ activation attenuates total free fatty acid and triglyceride accumulation in macrophages via the inhibition of Fatp1 expression

Lipid accumulation in macrophages interacts with microenvironment signals and accelerates diabetic atherosclerosis. However, the molecular mechanisms by which macrophage metabolism interacts with microenvironm...

Guozhu Ye, Han Gao, Zhichao Wang, Yi Lin, Xu Liao, Han Zhang… in Cell Death & Disease (2019)

Article

Rosmarinic acid attenuates cardiac fibrosis following long-term pressure overload via AMPKα/Smad3 signaling

Agonists of peroxisome proliferator-activated receptor gamma (PPAR-γ) can activate 5′ AMP-activated protein kinase alpha (AMPKα) and exert cardioprotective effects. A previous study has demonstrated that rosma...

**n Zhang, Zhen-Guo Ma, Yu-Pei Yuan, Si-Chi Xu, Wen-Ying Wei… in Cell Death & Disease (2018)

Article

ASIC1 and ASIC3 contribute to acidity-induced EMT of pancreatic cancer through activating Ca²⁺/RhoA pathway

Extracellular acid can have important effects on cancer cells. Acid-sensing ion channels (ASICs), which emerged as key receptors for extracellular acidic pH, are differently expressed during various diseases a...

Shuai Zhu, Hai-Yun Zhou, Shi-Chang Deng, Shi-Jiang Deng, Chi He… in Cell Death & Disease (2017)

Article

Y-chromosomes from skeletal remains of Chinese Expeditionary Force offer a clue to their paternal relatives

Shao-Qing Wen, **n-Zhu Tong, Chi-Zao Wang, Pan-**n Du, **-Yi Wang… in Science Bulletin (2016)

Article

Immunohistochemical Staining Reveals C-Reactive Protein Existing Predominantly as Altered Conformation Forms in Inflammatory Lesions

C-reactive protein (CRP) is an established marker of inflammation and has been proposed to play a proinflammatory role in pathologies of several diseases. CRP is primarily produced by the liver and released in...

** Shi, **ao-**n Li, Wei Zhu, Hong Yang, Chi Dong… in Acta Biologica Hungarica (2014)

Article

Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors

Combinatorial targeted therapies are more effective in treating cancer by blocking by-pass mechanisms or inducing synthetic lethality. However, their clinical application is hampered by resistance and toxicity...

Ozgur Sahin, Qingfei Wang, Samuel W Brady, Kenneth Ellis, Hai Wang… in Cell Research (2014)

Article

REACTIN: Regulatory activity inference of transcription factors underlying human diseases with application to breast cancer

Genetic alterations of transcription factors (TFs) have been implicated in the tumorigenesis of cancers. In many cancers, alteration of TFs results in aberrant activity of them without changing their gene expr...

Mingzhu Zhu, Chun-Chi Liu, Chao Cheng in BMC Genomics (2013)

Article

Inter-chain disulfide bond improved protein trans-splicing increases plasma coagulation activity in C57BL/6 mice following portal vein FVIII gene delivery by dual vectors

Protein trans-splicing based dual-vector factor VIII (FVIII) gene delivery is adversely affected by less efficiency of protein splicing. We sought to increase the amount of spliced FVIII protein and plasma coagul...

Fu**ang Zhu, ZeLong Liu, **aoLei Wang, **g Miao, HuiGe Qu… in Science China Life Sciences (2013)

Article

Enhanced plasma factor VIII activity in mice via cysteine mutation using dual vectors

Hemophilia A is caused by a genetic mutation in coagulation factor VIII (FVIII) gene and gene therapy is considered to be a promising strategy for its treatment. We recently demonstrated that co-delivery of tw...

Fu**ang Zhu, ZeLong Liu, **g Miao, HuiGe Qu, **aoYan Chi in Science China Life Sciences (2012)