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  1. Article

    Open Access

    Exploring the inverse relationship between serum total bilirubin and systemic immune-inflammation index: insights from NHANES data (2009–2018)

    Bilirubin is known for its multifaceted attributes, including antioxidant, anti-inflammatory, immunomodulatory, and antiapoptotic properties. The systemic immune-inflammation index (SII) is a recent marker tha...

    Shan-Shan Huang, Yi Ding, **ao-Na Yi, Hai-Yan Mao in European Journal of Medical Research (2024)

  2. Article

    Open Access

    Sodium tanshinone IIA sulfonate protects vascular relaxation in ApoE-knockout mice by inhibiting the SYK-NLRP3 inflammasome-MMP2/9 pathway

    Hyperlipidemia damages vascular wall and serves as a foundation for diseases such as atherosclerosis, hypertension and stiffness. The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is ...

    Hai-Hua Liu, Wei Wei, Fei-Fei Wu, Lu Cao, Bing-Jie Yang in BMC Cardiovascular Disorders (2024)

  3. No Access

    Article

    Psychological Status and Warfarin Therapy in Patients after Valve Replacement during the COVID-19 Pandemic: A Cross-sectional Study

    The standardization of warfarin anticoagulant therapy is the key to lifelong treatment for patients after heart valve replacement. The present study explored the possible risk factors for anxiety and depressio...

    **ao-yan Chen, Sheng He, Zhen Tan, Feng Gao, Hui Jiang, Lu Chen in Current Medical Science (2024)

  4. No Access

    Article

    Epstein-Barr virus causes vascular abnormalities in epithelial malignancies through upregulating ANXA3-HIF-1α-VEGF pathway

    Angiogenesis is one of the characteristics of malignant tumors, and persistent generation of abnormal tumor blood vessels is an important factor contributing to tumor treatment resistance. Epstein-Barr virus (...

    Yuanyuan Chen, Mu** Di, Yan Tang, **g**g Zhao, Qi**g Wang, Zhixing Guo in Oncogene (2024)

  5. Article

    Open Access

    Hemothorax caused by injury of musculophrenic artery after ultrasound-guided percutaneous liver biopsy: a case report

    Hemorrhage is the most common major complication after liver biopsy. Hemothorax is one type of bleeding and is very rare and dangerous. Several cases of hemothorax subsequent to liver biopsy have been document...

    **g-ru Yang, Sai Wu, Jian Li, **ao-juan Tian in Journal of Medical Case Reports (2024)

  6. Article

    Open Access

    Physical frailty, genetic predisposition, and incident dementia: a large prospective cohort study

    Physical frailty and genetic factors are both risk factors for increased dementia; nevertheless, the joint effect remains unclear. This study aimed to investigated the long-term relationship between physical f...

    Pei-Yang Gao, Ling-Zhi Ma, Xue-Jie Wang, Bang-Sheng Wu in Translational Psychiatry (2024)

  7. No Access

    Article

    Targeting Therapeutic Windows for Rheumatoid Arthritis Prevention

    Rheumatoid arthritis (RA) is a worldwide public health problem. Interventions to delay or prevent the onset of RA have attracted much attention in recent years, and researchers are now exploring various preven...

    Kai-xin Gao, Yi-hong Yang, Qi Liang, Li-yan Mei in Chinese Journal of Integrative Medicine (2024)

  8. No Access

    Article

    RNA m6A methylation and regulatory proteins in pulmonary arterial hypertension

    m6A (N6‑methyladenosine) is the most common and abundant apparent modification in mRNA of eukaryotes. The modification of m6A is regulated dynamically and reversibly by methyltransferase (writer), demethylase ...

    Zhe Wang, Yi-Xuan Zhang, Jun-Zhuo Shi, Yi Yan, Lu-Ling Zhao in Hypertension Research (2024)

  9. No Access

    Article

    Intraocular schwannoma: case series of 28 patients and literature review

    Intraocular schwannoma is a rare tumour, which is often misdiagnosed. We presented the demographics and clinical characteristics of patients with intraocular schwannoma.

    Li Dong, **ao-Lin Xu, He-Yan Li, Qiong Yang, Rui-Heng Zhang, Wen-Bin Wei in Eye (2024)

  10. Article

    Open Access

    Trends in prevalence of hearing loss in adults in the USA 1999–2018: a cross-sectional study

    A better understanding of how the prevalence of hearing loss and its associated factors change over time could help in develo** an appropriate program to prevent the development of hearing loss.

    Fengxin Mo, Shiheng Zhu, Hanlu Jia, Yuan **a, Li Lang, Qiutong Zheng in BMC Public Health (2024)

  11. Article

    Open Access

    XELOX (capecitabine plus oxaliplatin) plus bevacizumab (anti-VEGF-A antibody) with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer: a multicenter, open-label, randomized, controlled, phase 3 trial

    Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer (mCRC), but the prognosis remains poor. This phase 3 trial ...

    Qiu-Zhong Pan, **g-**g Zhao, Liang Liu in Signal Transduction and Targeted Therapy (2024)

  12. Article

    Open Access

    Blood leukocytes as a non-invasive diagnostic tool for thyroid nodules: a prospective cohort study

    Thyroid nodule (TN) patients in China are subject to overdiagnosis and overtreatment. The implementation of existing technologies such as thyroid ultrasonography has indeed contributed to the improved diagnost...

    Feihang Wang, Danyang Zhao, Wang-yang Xu, Yiying Liu, Huiyi Sun in BMC Medicine (2024)

  13. No Access

    Article

    Immediate Effect of Electro-acupuncture on Endometrial Blood Flow in Patients with Recurrent Implantation Failure: A Randomized Controlled Trial

    To investigate the immediate effects of electro-acupuncture (EA) on endometrial blood flow among recurrent implantation failure (RIF) patients.

    Yuan-yuan Lai, Li-ying Liu, Yong-na Wu in Chinese Journal of Integrative Medicine (2024)

  14. No Access

    Article

    Dynamic Treatment Strategy of Chinese Medicine for Metastatic Colorectal Cancer Based on Machine Learning Algorithm

    To establish the dynamic treatment strategy of Chinese medicine (CM) for metastatic colorectal cancer (mCRC) by machine learning algorithm, in order to provide a reference for the selection of CM treatment str...

    Yu-ying Xu, Qiu-yan Li, Dan-hui Yi, Yue Chen in Chinese Journal of Integrative Medicine (2024)

  15. Article

    Open Access

    A nomogram model for predicting intramyocardial hemorrhage post-PCI based on SYNTAX score and clinical features

    The aim of this study is to develop a nomogram model for predicting the occurrence of intramyocardial hemorrhage (IMH) in patients with Acute Myocardial Infarction (AMI) following Percutaneous Coronary Interve...

    Yin-shuang Yang, De-yang **, Yang Duan, Miao Yu, Kai Liu in BMC Cardiovascular Disorders (2024)

  16. Article

    Open Access

    Risk assessment of imported malaria in China: a machine learning perspective

    Following China’s official designation as malaria-free country by WHO, the imported malaria has emerged as a significant determinant impacting the malaria reestablishment within China. The objective of this st...

    Shuo Yang, Ruo-yang Li, Shu-ning Yan, Han-yin Yang, Zi-you Cao in BMC Public Health (2024)

  17. No Access

    Article

    Children with severe neurological symptoms associated with SARS-CoV-2 infection during Omicron pandemic in China

    To analyze the clinical characteristics and outcomes of children with severe neurological symptoms associated with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection during the Omicron ...

    Tao Zhang, Qiao-Feng Zhang, Hong-Mei Yang, Pin Liu, Peng Sun in Pediatric Research (2024)

  18. No Access

    Article

    Ki-67 Change in Anthracyline-containing Neoadjuvant Chemotherapy Response in Breast Cancer

    Anthracycline-containing regimens are irreplaceable in neoadjuvant chemotherapy (NAC) for breast cancer (BC) at present. However, 30% of early breast cancer (EBC) patients are resistant to anthracycline-contai...

    Zi-guo Yang, Le-hao Ren, Feng Wang, Pi-lin Wang, Wen-yan Wang in Current Medical Science (2024)

  19. No Access

    Article

    Disease-Related Factors Associated with Acupuncture Response in Patients with Chronic Tension-Type Headache: A Secondary Analysis of A Randomized Controlled Trial

    To explore the demographic and disease-related factors associated with acupuncture response in patients with chronic tension-type headache (CTTH).

    Wei Cao, Lu Wang, Ting-hui Hou, Yun-zhou Shi in Chinese Journal of Integrative Medicine (2024)

  20. Article

    Open Access

    Neutrophil-to-lymphocyte ratio associated with symptomatic saccular unruptured intracranial aneurysm

    Whether symptomatic unruptured intracranial aneurysms (UIAs) lead to change in circulating inflammation remains unclear. This study aims to evaluate the role of hematological inflammatory indicators in predict...

    De-**ang Zheng, Yi-Yang Lv, **ao-**g Zhang in European Journal of Medical Research (2024)

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