26 Result(s)
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Article
Effect of Magnetic Field Intensity on Carbothermal Reduction Characteristics of Bayan Obo Iron Ore
The coal-based direct reduction process has been coupled with the magnetic field-enhanced reduction technique. The effects of the magnetic field intensity on reduction efficiency, phase changes of the iron-bea...
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Article
Open AccessCarbenoid-involved reactions integrated with scaffold-based screening generates a Nav1.7 inhibitor
The discovery of selective Nav1.7 inhibitors is a promising approach for develo** anti-nociceptive drugs. In this study, we present a novel oxindole-based readily accessible library (OREAL), which is charact...
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Article
Detection of bruised yellow peach using hyperspectral imaging combined with curvature-assisted Hough transform circle detection and improved Otsu
The quality of yellow peaches was severely reduced due to bruising. Detection of bruised areas in yellow peach is easily disturbed by the calyx and stem ends. Therefore, it is proposed to utilize hyperspectral...
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Article
Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression
Telomere dysfunction is intricately linked to the aging process and stands out as a prominent cancer hallmark. Here we demonstrate that telomerase activity is differentially regulated in cancer and normal cell...
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Article
A general copper-catalysed enantioconvergent C(sp3)–S cross-coupling via biomimetic radical homolytic substitution
Although α-chiral C(sp3)–S bonds are of enormous importance in organic synthesis and related areas, the transition-metal-catalysed enantioselective C(sp3)–S bond construction still represents an underdeveloped do...
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Article
Artemisia argyi H. Lév. & Vaniot: a comprehensive review on traditional uses, phytochemistry, and pharmacological activities
Artemisia argyi, a perennial herb of the genus Artemisia, is recorded as medicine for the treatment of various diseases, such as metrorrhagia, menorrhagia, irregular menstruation, hemorrhage, dysmenorrhea, eczema...
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Article
Facile self-oxidized Ni nano-foam as high-performance catalyst for hydrogen and oxygen evolution
Development of high-performance catalysts with facile, self-supporting, simple and noble-metal-free features for hydrogen and oxygen evolution reactions (HER and OER) is a long-lasting pursuit. Herein, a facil...
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Article
Structures of the ADGRG2–Gs complex in apo and ligand-bound forms
Adhesion G protein-coupled receptors are elusive in terms of their structural information and ligands. Here, we solved the cryogenic-electron microscopy (cryo-EM) structure of apo-ADGRG2, an essential membrane...
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Article
Effect of different drying techniques on structural characteristics and bioactivities of polysaccharides extracted from (Lithocarpus litseifolius [Hance] Chun) sweet tea leaves
Sweet tea is made from the leaves of Lithocarpus litseifolius (Hance) Chun, which is an herbal tea widely consumed in Chinese folk. In this study, five drying techniques were applied to dry sweet tea leaves, and ...
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Article
Two New Furo[3,2-c]Quinolines from the Stems of Nicotiana tabacum and Their Anti-Tobacco Mosaic Virus Activity
Two new (1 and 2), together with two known (3 and 4), quinoline alkaloids were isolated from the stems of Nicotiana tabacum. Their structures were elucidated using spectroscopic methods, including extensive 1H, 1...
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Article
A β-sheet-targeted theranostic agent for diagnosing and preventing aggregation of pathogenic peptides in Alzheimer’s disease
Amyloid-β peptide (Aβ) aggregates, particularly Aβ oligomers, are established biomarker and toxic species in Alzheimer’s disease (AD). Early detection and disaggregation of Aβ aggregates are of great importanc...
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Article
Arylbenzofuran Lignans from the Seeds of Arctium lappa and Their Bioactivity
Two new (1 and 2) and two known arylbenzofuran lignans (3 and 4) were isolated from the seeds of Arctium lappa. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniq...
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Article
Silver Nanoplates and Gold Nanospheres as Probesfor Revealing an “Interference” Phenomenon in a Simultaneous Quantitative Immunochromatographic Assay
Escherichia coli O157:H7 and Salmonella choleraesuis are two important foodborne pathogens that cause illnesses and even deaths. Rapid and convenient methods, such as immunochromatographic assays (ICAs), are usef...
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Article
Open AccessDesign, synthesis, antiviral bioactivities and interaction mechanisms of penta-1,4-diene-3-one oxime ether derivatives containing a quinazolin-4(3H)-one scaffold
penta-1,4-diene-3-one oxime ether and quinazolin-4(3H)-one derivatives possess favorable agricultural activities. Aiming to discover novel molecules with highly-efficient agricultural activities, a series of pent...
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Article
Crystal Structures, Thermal Behavior Analysis and Thermal Safety of Two Energetic Salts of Hydrazinyl-1,2,4,5-tetrazine with 3,5-Dinitrosalicylic Acid
Two energetic salts, DPHT DNS H2O(1) and DHT 2DNS 2H2O(2)[DPHT=3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-hydrazinyl-1,2,4,5-tetrazine; DHT=3,6-dihydrazinyl-1,2,4,5-tetrazine], were synthesized from S-tetrazine with 3,5-...
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Article
Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin
Signals from 800 G-protein-coupled receptors (GPCRs) to many SH3 domain-containing proteins (SH3-CPs) regulate important physiological functions. These GPCRs may share a common pathway by signaling to SH3-CPs ...
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Article
Erratum: Continuous directed evolution of aminoacyl-tRNA synthetases
Nat. Chem. Biol. 13, 1253–1260 (2017); published online 16 October 2017; corrected after print 1 December 2017 In the version of this article initially published, the label colors for p-NF and p-IF in the key ...
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Article
A Electrochemical Sensor for Melamine Detection Based on Copper-Melamine Complex Using OMC Modified Glassy Carbon Electrode
A simple sensor ordered mesoporous carbon/glassy carbon electrode (OMC/GCE) is developed in this paper for melamine (Mel) detection, which is based on conversion of Mel from non-electroactive Mel to electroact...
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Article
Continuous directed evolution of aminoacyl-tRNA synthetases
The use of phage-assisted continuous evolution (PACE) with both positive and negative selection enables the rapid development of orthogonal aminoacyl-tRNA synthetases with high activity and selectivity for non...
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Article
Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase
The N-terminal domain structure of pyrrolysyl-tRNA synthetase (PylRS) reveals details of its tRNA specificity and facilitates the improvement of its selectivity for non-canonical amino acids by phage-assisted ...
