207 Result(s)
within
**-Tao Guo
Science, Humanities and Social Sciences, multidisciplinary
-
Article
Open AccessDonor-acceptor bulk-heterojunction sensitizer for efficient solid-state infrared-to-visible photon up-conversion
Solid-state infrared-to-visible photon up-conversion is important for spectral-tailoring applications. However, existing up-conversion systems not only suffer from low efficiencies and a need for high excitati...
-
Article
Open AccessAcetylation-dependent regulation of core spliceosome modulates hepatocellular carcinoma cassette exons and sensitivity to PARP inhibitors
Despite the importance of spliceosome core components in cellular processes, their roles in cancer development, including hepatocellular carcinoma (HCC), remain poorly understood. In this study, we uncover a c...
-
Article
Open AccessMetabolic phenoty** reveals an emerging role of ammonia abnormality in Alzheimer’s disease
The metabolic implications in Alzheimer’s disease (AD) remain poorly understood. Here, we conducted a metabolomics study on a moderately aging Chinese Han cohort (n = 1397; mean age 66 years). Conjugated bile aci...
-
Article
Open AccessChromosome-level genome assembly of the threatened resource plant Cinnamomum chago
Cinnamomum chago is a tree species endemic to Yunnan province, China, with potential economic value, phylogenetic importance, and conservation priority. We assembled the genome of C. chago using multiple sequenci...
-
Article
Open AccessUsing genome and transcriptome data from African-ancestry female participants to identify putative breast cancer susceptibility genes
African-ancestry (AA) participants are underrepresented in genetics research. Here, we conducted a transcriptome-wide association study (TWAS) in AA female participants to identify putative breast cancer susce...
-
Article
Open AccessFine-map** analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unkn...
-
Article
Open AccessNarazaciclib, a novel multi-kinase inhibitor with potent activity against CSF1R, FLT3 and CDK6, shows strong anti-AML activity in defined preclinical models
CSF1R is a receptor tyrosine kinase responsible for the growth/survival/polarization of macrophages and overexpressed in some AML patients. We hypothesized that a novel multi-kinase inhibitor (TKi), narazacicl...
-
Article
Open AccessInhibition of ACSS2-mediated histone crotonylation alleviates kidney fibrosis via IL-1β-dependent macrophage activation and tubular cell senescence
Histone lysine crotonylation (Kcr), as a posttranslational modification, is widespread as acetylation (Kac); however, its roles are largely unknown in kidney fibrosis. In this study, we report that histone Kcr...
-
Article
Open AccessA chromosome-level genome assembly of the spider mite Tetranychus piercei McGregor
Despite the rapid advances in sequencing technology, limited genomic resources are currently available for phytophagous spider mites, which include many important agricultural pests. One of these pests is Tetrany...
-
Article
Open AccessStatins improve cardiac endothelial function to prevent heart failure with preserved ejection fraction through upregulating circRNA-RBCK1
Heart failure with preserved ejection fraction (HFpEF) is associated with endothelial dysfunction. We have previously reported that statins prevent endothelial dysfunction through inhibition of microRNA-133a (...
-
Article
Open AccessCold-induced FOXO1 nuclear transport aids cold survival and tissue storage
Cold-induced injuries severely limit opportunities and outcomes of hypothermic therapies and organ preservation, calling for better understanding of cold adaptation. Here, by surveying cold-altered chromatin a...
-
Article
Open AccessEpidemiologic changes of a longitudinal surveillance study spanning 51 years of scrub typhus in mainland China
Scrub typhus may be one of the world’s most prevalent, neglected and serious, but easily treatable, febrile diseases. It has become a significant potential threat to public health in China. In this study we us...
-
Article
Open AccessMolecular mechanism of antihistamines recognition and regulation of the histamine H1 receptor
Histamine receptors are a group of G protein-coupled receptors (GPCRs) that play important roles in various physiological and pathophysiological conditions. Antihistamines that target the histamine H1 receptor (H
-
Article
Open AccessExperimental study on failure characteristics and rheological properties of pillar-like rock samples with different shapes
The stability of coal pillar is extremely important to the control of rock strata movement and surface subsidence. It is of great significance for mining design to analyze the stability and failure characteris...
-
Article
Open AccessA toxin-antidote system contributes to interspecific reproductive isolation in rice
Breakdown of reproductive isolation facilitates flow of useful trait genes into crop plants from their wild relatives. Hybrid sterility, a major form of reproductive isolation exists between cultivated rice (Oryz...
-
Article
Open AccessA phosphoinositide switch mediates exocyst recruitment to multivesicular endosomes for exosome secretion
Exosomes are secreted to the extracellular milieu when multivesicular endosomes (MVEs) dock and fuse with the plasma membrane. However, MVEs are also known to fuse with lysosomes for degradation. How MVEs are ...
-
Article
Open AccessMCM10, a potential diagnostic, immunological, and prognostic biomarker in pan-cancer
Microchromosome maintenance (MCM) proteins are a number of nuclear proteins with significant roles in the development of cancer by influencing the process of cellular DNA replication. Of the MCM protein family...
-
Article
Open AccessChronic cough relief by allosteric modulation of P2X3 without taste disturbance
P2X receptors are cation channels that sense extracellular ATP. Many therapeutic candidates targeting P2X receptors have begun clinical trials or acquired approval for the treatment of refractory chronic cough...
-
Article
Open AccessProteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ
The progression of urothelial bladder cancer (UC) is a complicated multi-step process. We perform a comprehensive multi-omics analysis of 448 samples from 190 UC patients, covering the whole spectrum of diseas...
-
Article
Open AccessLILRB2/PirB mediates macrophage recruitment in fibrogenesis of nonalcoholic steatohepatitis
Inhibition of immunocyte infiltration and activation has been suggested to effectively ameliorate nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B (PirB) and its human ortholog recept...
