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Article
Open AccessDevelopment of a novel testis-on-a-chip that demonstrates reciprocal crosstalk between Sertoli and Leydig cells in testicular tissue
The reciprocal crosstalk between testicular Sertoli and Leydig cells plays a vital role in supporting germ cell development and maintaining testicular characteristics and spermatogenesis. Conventional 2D and t...
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Article
Predictors associated with the rate of progression of nigrostriatal degeneration in Parkinson’s disease
Parkinson’s disease (PD) manifests as a wide variety of clinical phenotypes and its progression varies greatly. However, the factors associated with different disease progression remain largely unknown.
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Article
Medium Chain Length Polyhydroxyalkanoate Production by Engineered Pseudomonas gessardii Using Acetate-formate as Carbon Sources
Production of medium chain length polyhydroxyalkanoate (mcl-PHA) was attempted using Pseudomonas gessardii NIBRBAC000509957, which was isolated from Sunchang, Jeollabuk-do, Republic of Korea (35°24′27.7"N, 127°09...
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Article
Open AccessReduction in limb-movement complexity at term-equivalent age is associated with motor developmental delay in very-preterm or very-low-birth-weight infants
Reduced complexity during the writhing period can be crucial in the spontaneous movements of high-risk infants for neurologic impairment. This study aimed to verify the association between quantified complexit...
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Article
Dual suppressive effect of p-coumaric acid on pigmentation in B16F10 cells
Hyperpigmentation, frequently triggered by an excessive production of melanin, is a common issue within the realms of dermatology and cosmetology. In addition to regulating tyrosinase activity, the autophagy p...
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Article
Open AccessIntegration of National Health Insurance claims data and animal models reveals fexofenadine as a promising repurposed drug for Parkinson’s disease
Parkinson’s disease (PD) is a common and costly progressive neurodegenerative disease of unclear etiology. A disease-modifying approach that can directly stop or slow its progression remains a major unmet need...
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Article
Open AccessDiffusing capacity as an independent predictor of acute exacerbations in chronic obstructive pulmonary disease
A weak correlation between diffusing capacity of the lung for carbon monoxide (DLCO) and emphysema has been reported. This study investigated whether impaired DLCO in chronic obstructive pulmonary disease (COPD) ...
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Article
Open AccessMitochondrial matrix RTN4IP1/OPA10 is an oxidoreductase for coenzyme Q synthesis
Targeting proximity-labeling enzymes to specific cellular locations is a viable strategy for profiling subcellular proteomes. Here, we generated transgenic mice (MAX-Tg) expressing a mitochondrial matrix-targe...
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Article
Open AccessClinical outcomes of long-term inhaled combination therapies in patients with bronchiectasis and airflow obstruction
Few studies have reported which inhaled combination therapy, either bronchodilators and/or inhaled corticosteroids (ICSs), is beneficial in patients with bronchiectasis and airflow obstruction. Our study compa...
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Article
Open AccessDevelopment of an offline OOH advertising recommendation system using negative sampling and deep interest network
The out-of-home (OOH) advertising market has been operated exclusively following the know-how of salespeople. Thus, it is difficult to make scientific decisions and systematically provide various options to ad...
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Article
Open AccessEfficacy and safety of HIP1601 (dual delayed-release esomeprazole) 40 mg in erosive esophagitis compared to HGP1705 (delayed-release esomeprazole) 40 mg: a multicenter, randomized, double-blind, non-inferiority study
Proton-pump inhibitors (PPIs) are the most effective drugs for treating acid-related disorders. However, once-daily dosing with conventional PPIs fail to fully control acid secretion over 24 h. This study aime...
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Article
Correction: Recent advancement in enhanced soil flushing for remediation of petroleum hydrocarbon‑contaminated soil: a state‑of‑the‑art review
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Article
Open AccessReal-time machine learning model to predict in-hospital cardiac arrest using heart rate variability in ICU
Predicting in-hospital cardiac arrest in patients admitted to an intensive care unit (ICU) allows prompt interventions to improve patient outcomes. We developed and validated a machine learning-based real-time...
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Article
Open AccessPulmonary artery catheter monitoring versus arterial waveform-based monitoring during liver transplantation: a retrospective cohort study
Although pulmonary artery catheter (PAC) has been used during liver transplantation surgery, the usefulness of PAC has rarely been investigated. We evaluated whether the use of PAC is associated with better cl...
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Article
Wickerhamomyces ciferrii Auxotroph and Expression Vector for Improved Production of Tetraacetyl Phytosphingosine
Tetraacetyl phytosphingosine (TAPS) is a precursor that has antibacterial and wound-healing properties and is used in the synthesis of ceramides. Wickerhamomyces ciferrii is a non-conventional yeast that has the ...
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Article
Open AccessPaedoksan ameliorates allergic disease through inhibition of the phosphorylation of STAT6 in DNCB-induced atopic dermatitis like mice
Various allergic diseases such as atopic dermatitis (AD), allergic rhinitis, and asthma are considered incurable conditions that have yet to be fully conquered. Paedoksan (PDS), an herbal preparation consistin...
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Article
Recent advancement in enhanced soil flushing for remediation of petroleum hydrocarbon-contaminated soil: a state-of-the-art review
Remediation of persistent organic pollutants in soil especially total petroleum hydrocarbon (TPH) is of global concern due to its toxicity and health implications. Soil flushing has been considered a promising...
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Article
Open AccessSerum neutrophil gelatinase-associated lipocalin and lactate level during surgery predict acute kidney injury and early allograft dysfunction after liver transplantation
Early allograft dysfunction (EAD) and acute kidney injury (AKI) are common and clinically important complications after liver transplantation. Serum lactate level at the end of surgery could predict EAD and ne...
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Article
Open AccessSARS-CoV-2 Omicron variant causes brain infection with lymphoid depletion in a mouse COVID-19 model
The Omicron variant has become the most prevalent SARS-CoV-2 variant. Omicron is known to induce milder lesions compared to the original Wuhan strain. Fatal infection of the Wuhan strain into the brain has bee...
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Article
Open AccessThe factors associated with mortality and progressive disease of nontuberculous mycobacterial lung disease: a systematic review and meta-analysis
This systematic review and meta-analysis aimed to comprehensively evaluate the factors associated with mortality and progressive disease in NTM-LD patients. We conducted a literature search to identify the eli...
