17 Result(s)
within
**-Hyuk Kwon
Cell Biology
-
Article
Open AccessEpigenetic repression of CHCHD2 enhances survival from single cell dissociation through attenuated Rho A kinase activity
During in vitro culture, human pluripotent stem cells (hPSCs) often acquire survival advantages characterized by decreased susceptibility to mitochondrial cell death, known as “culture adaptation.” This adapta...
-
Article
A synergistic partnership between IL-33/ST2 and Wnt pathway through Bcl-xL drives gastric cancer stemness and metastasis
ST2 functions as a receptor for the cytokine IL-33. It has been implicated in carcinogenesis. In this study, we sought to mechanistically determine how ST2 and IL-33 function to support cancer stem cell (CSC) ...
-
Article
Open AccessDichotomous role of Shp2 for naïve and primed pluripotency maintenance in embryonic stem cells
The requirement of the Mek1 inhibitor (iMek1) during naïve pluripotency maintenance results from the activation of the Mek1-Erk1/2 (Mek/Erk) signaling pathway upon leukemia inhibitory factor (LIF) stimulation.
-
Article
Establishment of bioreactor cultures for the production of chlorogenic acid and ferulic acid from adventitious roots by optimization of culture conditions in Angelica acutiloba (Siebold & Zucc.) Kitag
Adventitious roots were induced from root explants of Angelica acutilobaand suspension cultures were established in shake flasks. The effect of different concentrations of indole acetic acid (IBA, 0–38.4 µM), the...
-
Article
Telmisartan Inhibits the NLRP3 Inflammasome by Activating the PI3K Pathway in Neural Stem Cells Injured by Oxygen-Glucose Deprivation
Angiotensin II receptor blockers (ARBs) have been shown to exert neuroprotective effects by suppressing inflammatory and apoptotic responses. In the present study, the effects of the ARB telmisartan on the NLR...
-
Article
CD9 induces cellular senescence and aggravates atherosclerotic plaque formation
CD9, a 24 kDa tetraspanin membrane protein, is known to regulate cell adhesion and migration, cancer progression and metastasis, immune and allergic responses, and viral infection. CD9 is upregulated in senesc...
-
Article
Sirtuin 6 in preosteoclasts suppresses age- and estrogen deficiency-related bone loss by stabilizing estrogen receptor α
Emerging evidence indicates that estrogen receptor (ER) α is an important modulator of bone homeostasis, which occurs partly by promoting osteoclast apoptosis. Sirtuin 6 (Sirt6) is an anti-aging molecule, and ...
-
Article
Open AccessCep131 overexpression promotes centrosome amplification and colon cancer progression by regulating Plk4 stability
The initiation of centrosome duplication is regulated by the Plk4/STIL/hsSAS-6 axis; however, the involvement of other centrosomal proteins in this process remains unclear. In this study, we demonstrate that C...
-
Article
Recapitulation of pharmacogenomic data reveals that invalidation of SULF2 enhance sorafenib susceptibility in liver cancer
Gene mutations play critical roles during cancer development and progression, and therefore represent targets for precision medicine. Here we recapitulated the pharmacogenomic data to delineate novel candidate...
-
Article
Prdm4 induction by the small molecule butein promotes white adipose tissue browning
Microarray analysis of butein-treated adipocytes results in the identification of the PR domain containing 4 (Prdm4) transcription factor, which stimulates WAT browning and lipolysis and protects against diet-...
-
Article
γ-Glutamyl transpeptidase (GgtA) of Aspergillus nidulans is not necessary for bulk degradation of glutathione
Aspergillus nidulans exhibited high γ-glutamyl transpeptidase (γGT) activity in both carbon-starved and carbon-limited cultures. Glucose repressed, but casein peptone increased γGT production. Nu...
-
Article
A clinical and histological evaluation for healing of dehiscence defects filled with an absorbable atelocollagen sponge in dogs
The objective of this study was to evaluate the effect of absorbable atelocollagen sponge on healing of hard tissue of buccal dehiscence defects in mongrel dogs. The mandibular second and fourth premolars of 1...
-
Article
OsREL2, a rice TOPLESS homolog functions in axillary meristem development in rice inflorescence
The morphology of the rice inflorescence, called the panicle, is determined mainly by the activities of axillary meristems including primary, secondary, and spikelet meristems. Recently, in maize, the RAMOSA1 ENH...
-
Article
Generation of Cancerous Neural Stem Cells Forming Glial Tumor by Oncogenic Stimulation
Neural stem cells in the brain have been shown to be ‘cells of origin’ of certain brain cancers, most notably astrocytomas and medulloblastoma. In particular, in a mouse model, the targeting of genetic modific...
-
Article
BMP4 signaling mediates Zeb family in develo** mouse tooth
Tooth morphogenesis is regulated by sequential and reciprocal interaction between oral epithelium and neural-crest-derived ectomesenchyme. The interaction is controlled by various signal molecules such as bone...
-
Article
Association of Oxidative Stress with Postmenopausal Osteoporosis and the Effects of Hydrogen Peroxide on Osteoclast Formation in Human Bone Marrow Cell Cultures
It has been suggested that oxidative stress is associated with the pathogenesis of osteoporosis. The objective of this study was to explore the association between a marker of oxidative stress and either bone ...
-
Article
Gβγ-mediated growth and developmental control in Aspergillus fumigatus
The roles of the Gβγ subunits of the opportunistic human pathogen Aspergillus fumigatus were investigated. The predicted AfuSfaD (Gβ) protein consists of 353 amino acids and shows 94–98% similarity with other Asp...
