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1,017 Result(s)
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Article
Phylogenomics, divergence times and notes of orders in Basidiomycota
Basidiomycota is one of the major phyla in the fungal tree of life. The outline of Basidiomycota provides essential taxonomic information for researchers and workers in mycology. In this study, we present a ti...
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Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor
Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins, showing a potential threat to humans. Here we report the infectivity and pathogenicity of the SARS-CoV-2-related virus, ...
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An Improved Grey Relational Theory Evaluation Method: Considering the Comprehensive Performance of Autonomous Vehicles in Virtual Test
Reasonable test scenarios and objective evaluation methods can rapidly promote the development of autonomous vehicle technology. A new quantitative evaluation method for the comprehensive performance of autono...
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Open AccessAn ultra-short-acting benzodiazepine in thalamic nucleus reuniens undermines fear extinction via intermediation of hippocamposeptal circuits
Benzodiazepines, commonly used for anxiolytics, hinder conditioned fear extinction, and the underlying circuit mechanisms are unclear. Utilizing remimazolam, an ultra-short-acting benzodiazepine, here we revea...
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Open AccessPhylodynamics unveils invading and diffusing patterns of dengue virus serotype-1 in Guangdong, China from 1990 to 2019 under a global genoty** framework
The strong invasiveness and rapid expansion of dengue virus (DENV) pose a great challenge to global public health. However, dengue epidemic patterns and mechanisms at a genetic scale, particularly in term of c...
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Open AccessAdjuvants for cancer mRNA vaccines in the era of nanotechnology: strategies, applications, and future directions
Research into mRNA vaccines is advancing rapidly, with proven efficacy against coronavirus disease 2019 and promising therapeutic potential against a variety of solid tumors. Adjuvants, critical components of ...
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Light-induced stepped thermal relaxation in a Hofmann-type metal-organic framework
Spin-crossover (SCO) materials with light-induced multistability have potential applications in multi-addressable opto-magnetic memory devices and multiple switches. Here, we reported a three-dimensional Hofma...
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Chinese Medicine Prolongs Overall Survival of Chinese Patients with Advanced Gastric Cancer: Treatment Pattern and Survival Analysis of a 20-Year Real-World Study
To describe the treatment patterns and survival status of advanced gastric cancer (AGC) in China in the past two decades, and objectively evaluate the impact of standardized Chinese medicine (CM) treatment on ...
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Open AccessClinical significance and prospective mechanism of increased CDKN2A expression in small cell lung cancer
Although it has been shown that cyclin dependent kinase inhibitor 2A (CDKN2A) plays a significant role in a number of malignancies, its clinicopathological value and function in small cell lung cancer (SCLC) i...
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Amorphous NiMo3S13/nickel foam integrated anode for lithium-ion batteries
Although crystalline anode materials with long-range ordered lattice structure are in favor of facilitating the electron transfer, their structures are easily disrupted during long-term cycling due to the cont...
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Article
Onset of the Earth’s hydrological cycle four billion years ago or earlier
Widespread interaction between meteoric (fresh) water and emerged continental crust on the early Earth may have been key to the emergence of life, although when the hydrological cycle first started is poorly c...
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Acetylene/argon mixture plasma to build ultrathin carbon bridge of CFx/C/MnO2 for high-rate lithium primary battery
Forming an ultrathin conducting layer on a fluorinated carbon (CFx) surface for reducing severe electrochemical polarization in lithium/fluorinated carbon primary batteries (Li/CFx) remains a considerable challen...
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Open AccessMotor imagery-based brain–computer interface rehabilitation programs enhance upper extremity performance and cortical activation in stroke patients
The most challenging aspect of rehabilitation is the repurposing of residual functional plasticity in stroke patients. To achieve this, numerous plasticity-based clinical rehabilitation programs have been deve...
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Open AccessSpatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine
Aging and regeneration represent complex biological phenomena that have long captivated the scientific community. To fully comprehend these processes, it is essential to investigate molecular dynamics through ...
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Open AccessGenome assembly of Ottelia alismoides, a multiple-carbon utilisation aquatic plant
Ottelia Pers. is in the Hydrocharitaceae family. Species in the genus are aquatic, and China is their centre of origin in Asia. Ottelia alismoides (L.) Pers., which is distributed wor...
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Open AccessIntegrated and DC-powered superconducting microcomb
Frequency combs, specialized laser sources emitting multiple equidistant frequency lines, have revolutionized science and technology with unprecedented precision and versatility. Recently, integrated frequency...
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Article
Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers
Messenger RNA vaccines lack specificity for dendritic cells (DCs)—the most effective cells at antigen presentation. Here we report the design and performance of a DC-targeting virus-like particle pseudotyped w...
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Two New Anti-SARS-CoV-2 Naphthoquinones from Cigar-Tobacco-Derived Endophytic Fusarium oxysporum
In this study, two new naphthoquinones, 6-isopropyl-7-methoxy-2-(2-oxopropyl)naphthalene-1,4-dione (1) and 7-hydroxy-6-isopropyl-2-(2-oxopropyl)naphthalene-1,4-dione (2), together with five known new naphthoquino...
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Effect of Mn addition on microstructure and mechanical properties of GX40CrNiSi25-12 austenitic heat resistant steel
Three types of steels were designed on the basis of GX40CrNiSi25-12 austenitic heat resistant steel by adding different Mn contents (2wt.%, 6wt.%, and 12wt.%). Thermodynamic calculation, microstructure charact...
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Open AccessThe rise of baobab trees in Madagascar
The baobab trees (genus Adansonia) have attracted tremendous attention because of their striking shape and distinctive relationships with fauna1. These spectacular trees have also influenced human culture, inspir...