438 Result(s)
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Article
Lacticaseibacillus paracasei completely utilizes fructooligosacchrides in the human gut through β-fructosidase (FosE)
The fecal microbiota of two healthy adults was cultivated in a medium containing commercial fructooligosaccharides [FOS; 1-kestose (GF2), nystose (GF3), and 1F-fructofuranosylnystose (GF4)]. Initially, the propor...
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Article
Pleionea litopenaei sp. nov., isolated from the gastric tract of juvenile Pacific white shrimp Litopenaeus vannamei
A Gram-stain-negative, aerobic, rod-shaped and motile strain HL-JVS1T, was isolated from the gastric tract of a juvenile Pacific white shrimp. Molecular phylogenetic analysis based on 16S rRNA gene sequences of s...
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Article
Emission and Förster Resonance Energy Transfer Behaviors of Colloidal Quantum Dots in a Metal Nanohole
The reduction of the photoluminescence (PL) decay time of a colloidal quantum dot (QD) inserted into an Ag or Au surface nanohole and the efficiency enhancement of the Förster resonance energy transfer (FRET) ...
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Article
Tannic Acid Impedes the Proliferation of Bladder Cancer Cells by Elevating Mitochondrial Pathways of Apoptosis
Bladder cancer stands as a prevailing neoplasm among men globally, distinguished for its pronounced malignancy attributed to invasiveness and metastatic proclivity. Tannic acid (TA), an organic compound in man...
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Article
A Simple Structure of High Sensitivity of Plasmonic Photonic Crystal Fiber Sensors with Minimal Air Hole Density in Fiber Cladding
Surface plasmon resonance (SPR)-based photonic crystal fiber (PCF) sensors have advanced significantly in recent years, yet many proposed sensors suffer from low sensitivity or complex fabrication processes th...
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Article
Selenium Nanoparticles: Revolutionizing Nutrient Enhancement in Aquaculture – A Review
Aquaculture, a cornerstone of global food production, confronts myriad challenges including disease outbreaks and environmental degradation. Achieving nutritionally balanced aquafeed is critical for sustainabl...
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Article
Streptococcus taonis sp. nov., a novel bacterial species isolated from a blood culture of a patient
One Gram stain-positive, catalase-negative, α-hemolytic, chain-forming or paired cocci, designated ST22-14T, was isolated from a blood culture of a child with suspected infection. The results of 16S rRNA gene seq...
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Article
Role of sirtuin 1 (SIRT1) in regulation of autophagy and nuclear factor-kappa Beta (NF-ĸβ) pathways in sorafenib-resistant hepatocellular carcinoma (HCC)
Hepatocellular carcinoma (HCC) remains a major global health problem with high incidence and mortality. Diagnosis of HCC at late stages and tumour heterogeneity in patients with different genetic profiles are ...
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Article
High Sensitivity of Metasurface-Based Five-Band Terahertz Absorber
In this paper, we present a simple design of a sensing scheme based on a plasmonic metamaterial absorber operating at THz frequencies. The unit cell of the designed structure consists of a gold (Au) cross-bar-...
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Article
Experience Learned and Perspectives on Using Model-Integrated Evidence in the Regulatory Context for Generic Drug Products—a Meeting Report
This report summarizes relevant insights and discussions from a 2022 FDA public workshop titled Best Practices for Utilizing Modeling Approaches to Support Generic Product Development which illustrated how model-...
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Article
Genetic characterization of tetracycline-resistant Staphylococcus aureus with reduced vancomycin susceptibility using whole-genome sequencing
This study aimed to analyze the genetic characteristics of Staphylococcus aureus with reduced vancomycin susceptibility (RVS-SA). Whole-genome sequencing was performed on 27 RVS-SA clinical isolates, and comparat...
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Article
Glass-Based Nanobiosensor Immobilized with Oriented Antibody-Conjugated Gold Nanourchin for Targeted Detection of Breast Cancer Biomarker in Serum Using FT-NIR and SERS
A glass-based nanobiosensor is fabricated for non-destructive detection of overexpressed human epidermal growth factor receptor (HER-II) biomarker in breast cancer serum (BCS) using immobilized PEGylated gold ...
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Article
An Antibody-Dependent Cellular Cytotoxicity Assay for Detecting Ocrelizumab Neutralizing Antibody
Ocrelizumab (OCREVUS®) is a humanized anti-CD20 monoclonal antibody approved for the treatment of adult patients with relapsing multiple sclerosis (RMS) and primary progressive multiple sclerosis (PPMS). Here,...
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Article
Near- and Mid- Infrared Quintuple-Band Plasmonic Metamaterial Absorber
In nanophotonic devices, the absorption of electromagnetic waves plays a critical role. Attempting to achieve narrowband absorption with multiple operating wavelengths, particularly in the near- and mid-infrar...
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Article
Open AccessNeutralizing Antibody Validation Testing and Reporting Harmonization
Evolving immunogenicity assay performance expectations and a lack of harmonized neutralizing antibody validation testing and reporting tools have resulted in significant time spent by health authorities and sp...
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Article
Streamlining Food Effect Assessment — Are Repeated Food Effect Studies Needed? An IQ Analysis
Current regulatory guidelines on drug-food interactions recommend an early assessment of food effect to inform clinical dosing instructions, as well as a pivotal food effect study on the to-be-marketed formula...
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Article
Survey Outcome on Immunogenicity Risk Assessment Tools for Biotherapeutics: an Insight into Consensus on Methods, Application, and Utility in Drug Development
A survey conducted by the Therapeutic Product Immunogenicity (TPI) community within the American Association of Pharmaceutical Scientists (AAPS) posed questions to the participants on their immunogenicity risk...
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Article
Tunable Multiple Fano Resonance Plasmonic Nanosensor with an Oblique Path in a Pentagonal-Ring-Shaped Resonator
Multiple-mode Fano resonance-based plasmonic sensors are required and face a challenge in the wavelength range of visible/near-infrared/mid-infrared. This article proposes a multimode Fano resonance-based sens...
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Article
Screening potential polyhydroxyalkanoate-producing bacteria from wastewater sludge
We applied fluorescence staining of Nile red, polymerase chain reaction (PCR), and carbon substrate utilization and pressure tolerance analysis to execute three-stage screening for potential polyhydroxyalkanoa...
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Article
Open AccessBacillus predominates in the Ophiocordyceps pseudolloydii-infected ants, and it potentially improves protection and utilization of the host cadavers
The bacterial communities that colonize the cadaver environment of insects infected and killed by parasitic fungi can be selected by the sympatric fungi and provide novel impacts. In this study, we found that Bac...
