1,388 Result(s)
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Article
Intestinal polyps in American negroes and Nigerian africans
Forty Africans from Nigeria and 89 American negroes with colorectal polyps were analysed by age, sex and type of polyp. The Nigerians were much the younger group (mostly under 20 years of age, whereas most of ...
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Article
Effect of cholesterol on membrane Na,K-dependent adenosine triphosphatase activity
By feeding rats on a high-cholesterol diet or by treating rat brain membranes with cholesterol oxidase, preparations of membrane Na,K-ATPase differing in their cholesterol content were obtained. The cholestero...
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Article
Fatal basilar artery occlusion following cervical spine injury
A patient rendered acutely quadriplegic in an automobile accident was shown by angiography to have occlusion of the left vertebral artery. One month later, he abruptly became unconscious, apneic and died. Auto...
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A simple impregnation technique for thin and semithin enterochromaffin cells in sections
Constant, intense and precise impregnation of enterochromaffin (EC) cells was achieved simply by floating thin or semithin sections of gut mucosa, fixed in osmium tetroxide or in glutaraldehyde with postfixati...
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Application of the thiocarbohydrazide method for vicinal glycol group detection to the study of gastric mucosa endocrine cells
The thiocarbohydrazide-silver proteinate (TCH-SP) method was applied to the study of cat, rabbit and mouse gastric mucosa endocrine cells. After 24-h treatment with thiocarbohydrazide (TCH), glycogen was seen ...
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Structural and functional studies on C4b-binding protein, a regulatory component of the human complement system
The binding and cofactor activities of C4b-binding protein were examined before and after limited proteolysis by pepsin, trypsin and chymotrypsin. The major fragments generated were characterized by amino acid...
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Article
Effects of training on human tracking of electrocutaneous signals
The effects of training on a person's ability to perceive, interpret and utilize information presented via the tactile sense were examined by using a dual-channel electrocutaneous tracking approach. The electr...
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Recombinant α2 interferon is superior to doxorubicin for inoperable hepatocellular carcinoma: a prospective randomised trial
In a prospective trial of 75 Chinese patients with histologically proven inoperable hepatocellular carcinoma (HCC), 25 patients were randomised to receive doxorubicin 60-75 mg m-2 intravenously once every 3 we...
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Follow-up study on the use of leg braces issued to spinal cord injury patients
A letter questionnaire was sent to 250 spinal cord injury (SCI) patients with leg braces who were admitted to a VA Medical Centre from January 1978 to December 1984. There were 73 responses deemed to be comple...
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Article
Metabolism of methyltertiary-butyl ether by rat hepatic microsomes
Exposure to methyltertiary-butyl ether (MTBE), a commonly used octane booster in gasoline, has previously been shown to alter various muscle, kidney, and liver metabolic activities. In the present study, the meta...
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Article
Alteration of rat liver microsomal monooxygenase activities by gasoline treatment
Previous work has shown an increase in rat liver enzyme activities after chronic exposure to gasoline vapor. In the present study, male Sprague-Dawley rats were pretreated with unleaded gasoline at 1 and 5 ml/...
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Article
Fibroblasts are critical determinants in prostatic cancer growth and dissemination
Fibroblasts are important contributors to both benign and malignant growth of prostate epithelial cells in vivo. In the human prostate cancer model that we have established, we can grow human LNCaP tumors reprodu...
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Haemostatic changes and thromboembolic risk during tamoxifen therapy in normal women
Tamoxifen has been implicated as a risk factor for venous thrombosis in advanced breast cancer although the evidence for increased arterial or venous thrombosis with tamoxifen in early breast cancer is less cl...
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Article
Differential expression of cAMP-kinase subunits is correlated with growth in rat mammary carcinomas and uterus
The expression of the regulatory (RI and RII) and catalytic (C) subunits of cAMP-dependent protein kinase was found to depend on the growth-state in oestrogen-dependent DMBA-induced mammary adenocarcinomas as ...
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In vivo andin vitro approaches to study metastasis in human prostatic cancer
Prostate cancer is the most common malignancy in American males and is second only to lung cancer as a cause of death in the United States. Clinically, radical prostatectomy offers a patient with locally conta...
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A mouse model of Greig cephalo–polysyndactyly syndrome: the extra–toesJ mutation contains an intragenic deletion of the Gli3 gene
Greig cephalopolysyndactyly syndrome (GCPS) is an autosomal dominant disorder affecting limb and craniofacial development. Recently, the human GLI3 gene has been proposed to be a candidate gene for GCPS. Here we ...
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Estimation of the outcrossing rate in the chestnut blight fungus, Cryphonectria parasitica
The outcrossing rate in the chestnut blight fungus, Cryphonectria (Endothia) parasitica, was estimated in a natural population using data from six unlinked restriction fragment length polymorphism (RFLP) loci and...
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Article
Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1
Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant disorder characterized by neurodegeneration of the cerebellum, spinal cord and brainstem. A 1.2–Megabase stretch of DNA from the short arm of chrom...
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Article
Evidence for a mechanism predisposing to intergenerational CAG repeat instability in spinocerebellar ataxia type I
Spinocerebellar ataxia type I (SCAI) is an autosomal dominant neurodegenerative disease caused by the expansion of a CAG trinucleotide repeat on chromosome 6p. Normal alleles range from 19–36 repeats while SCA...
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Article
Protein kinase A (PK-A) regulatory subunit expression in colorectal cancer and related mucosa
Photoaffinity labelling (PAL) with [32P]8-azido-cAMP and polyacrylamide gel electrophoresis (PAGE) has been used to identify three specific cAMP-binding proteins (cAMP-BPs) within cytosols derived from the cen...
