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  1. No Access

    Chapter

    Mitochondrial Mutations and the Ageing Process

    We have proposed that the accumulation of random somatic gene mutations in the mitochondrial DNA (mtDNA) during life is an important contributor to the ageing process. The consequence of these mutations is the...

    Anthony W. Linnane, Alessandra Baumer… in Adenine Nucleotides in Cellular Energy Tra… (1992)

  2. No Access

    Article

    Structure of HIV-1 reverse transcriptase/DNA complex at 7 Å resolution showing active site locations

    AIDS, caused by human immunodeficiency virus (HIV), is one of the world's most serious health problems, with current protocols being inadequate for either prevention or successful long-term treatment. In retro...

    Edward Arnold, Alfredo Jacobo-Molina, Raymond G. Nanni, Roger L. Williams… in Nature (1992)

  3. No Access

    Article

    Functional expression of a rapidly inactivating neuronal calcium channel

    DIVERSE types of calcium channels in vertebrate neurons are important in linking electrical activity to transmitter release, gene expression and modulation of membrane excitability1. Four classes of Ca2+ channels...

    Patrick T. Ellinor, Ji-Fang Zhang, Andrew D. Randall, Mei Zhou, Thomas L. Schwarz… in Nature (1993)

  4. No Access

    Article

    Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels

    VOLTAGE-GATED Ca2+ channels link changes in membrane potential to the delivery of Ca2+, a key second messenger for many cellular responses1. Ca2+ channels show selectivity for Ca2+ over more plentiful ions such a...

    Jian Yang, Patrick T. Elllnor, William A. Sather, JI-Fang Zhang, Richard W. Tsien in Nature (1993)

  5. No Access

    Article

    Structural determinants of the blockade of N-type calcium channels by a peptide neurotoxin

    NEUROTOXINS that selectively block Na+, K+ or Ca2+ channels have provided valuable information about the functional diversity of the voltage-gated channel superfamily1. For Ca2+ channels, a variety of toxins have...

    Patrick T. Ellinor, Ji-Fang Zhang, William A. Horne, Richard W. Tsien in Nature (1994)

  6. No Access

    Article

    Molecular determinants of voltage-dependent inactivation in calcium channels

    VOLTAGE-DEPENDENT Ca2+ channels respond to membrane depolarization by conformational changes that control channel opening and eventual closing by inactivation1–3. The kinetics of inactivation differ considerably ...

    Ji-Fang Zhang, Patrick T. Ellinor, Richard W. Aldrich, Richard W. Tsien in Nature (1994)

  7. No Access

    Chapter and Conference Paper

    Front tracking: A parallelized approach for internal boundaries and interfaces

    Internal boundaries and interfaces are an important part of many fluid and solid modeling problems. Front Tracking contains a general interface framework, closely related to the non-manifold geometry used in C...

    James Glimm, John Grove, **ao Lin Li… in Applied Parallel Computing Computations in… (1996)

  8. No Access

    Article

    Quantum dynamics study for reaction of H2 + OD→H + HOD

    Yici Zhang, Yanbing Zhang, Desheng Zhang, Qinggang Zhang… in Chinese Science Bulletin (1997)

  9. No Access

    Article

    Uniqueness of limit cycles of quadratic system (III)m=0

    **ang Zhang, Qin Ye in Chinese Science Bulletin (1997)

  10. No Access

    Article

    Applying bases for “double control” artificial breeding of giant panda in captivity

    Dayuan Chen, **angfen Song, Chongwen Duan, Mingwen Li… in Chinese Science Bulletin (1997)

  11. No Access

    Article

    Magnetic circular dichroism of photosystem II reaction center complex

    Kunyun Yang, Chongqin Tang, Tingyun Kuang, Peisong Tang… in Chinese Science Bulletin (1997)

  12. No Access

    Article

    Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiPl

    Much of the predisposition to hereditary breast and ovarian cancer has been attributed to inherited defects in the BRCA1 tumour-suppressor gene1,2,3. The nuclear protein BRCA1 has the properties of a transcriptio...

    Kumaravel Somasundaram, Hongbing Zhang, Yi-**n Zeng, Yariv Houvras, Yi Peng… in Nature (1997)

  13. No Access

    Article

    Age distribution of the fauna 5.3 Ma B.P. and climatic deterioration events in North China

    Yunxiang Zhang, Danling Chen, **angxu Xue in Chinese Science Bulletin (1997)

  14. No Access

    Article

    Peptide bond formation by in vitro selected ribozymes

    An attractive solution to the problem of the origin of protein synthesis in an evolving ‘RNA world’ involves catalysis by nucleic acid without assistance from proteins1,2. Indeed, even the modern ribosome has bee...

    Biliang Zhang, Thomas R. Cech in Nature (1997)

  15. No Access

    Article

    A quantum mode theory of the micromaser

    Failure of the steady solution of the master equation was analysed. It was found that the state of sustained oscillation exists only when the ratio of photon decay rate γ to injection rate r is satisfied. Base...

    Renhong Liu, Weihan Tan, Wencang Xu, Jufang Zhang in Chinese Science Bulletin (1998)

  16. No Access

    Article

    Genomic organization of EDSV strain AA-2

    The genomic organization of egg drop syndrome virus strain AA-2 isolated in China is reported here. The genome was found to be 32 838 bp in length, approximately 2 kb shorter than those of the human subgenus C...

    Liyu Zeng, Qi **, **ggang Zhang, Maoxiang Li, Hong Li… in Chinese Science Bulletin (1998)

  17. No Access

    Article

    Mechanism of inversion metallogeny of quartz vein type gold deposits in the **aoqinling region

    There are a lot of important gold-bearing quartz veins in the **aoqinling metamorphic core complex. The quartz veins are strictly controlled by shear zones. Stress analysis indicates that the metallizing proce...

    Liangwei Xue, Quanzeng Shi, **angdong Yu, Yadong Zheng… in Chinese Science Bulletin (1998)

  18. No Access

    Article

    Discovery of granulite from the Fu** area in southern Qinling Mountains and its geological significance

    Two-pyroxene-bearing granulites were discovered for the first time in the Hercynian-lndosinian metamorphic belt of the southern Qinling Mountains. The granulites occur In the lower part of the Fu** complex a...

    Chun**g Wei, Chonghui Yang, Shouguang Zhang, Rongshe Li in Chinese Science Bulletin (1998)

  19. No Access

    Article

    Syn-deformationP-T paths of **aoqinling metamorphic core complex

    TheP-T paths of the **aoqinling metamorphic core complex (XMCC) have been investigated with the Gibbs method by researching the compositional changing of zoned epidotes which formed during syn-deformation metamor...

    Shuwen Liu, **jiang Zhang, Yadong Zheng in Chinese Science Bulletin (1998)

  20. No Access

    Article

    The structural model of P680

    Chunxi Zhang, **aodong Zhang, Liangbi Li, Qiyuan Zhang… in Chinese Science Bulletin (1999)

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