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  1. No Access

    Article

    Structure of HIV-1 reverse transcriptase/DNA complex at 7 Å resolution showing active site locations

    AIDS, caused by human immunodeficiency virus (HIV), is one of the world's most serious health problems, with current protocols being inadequate for either prevention or successful long-term treatment. In retro...

    Edward Arnold, Alfredo Jacobo-Molina, Raymond G. Nanni, Roger L. Williams… in Nature (1992)

  2. No Access

    Article

    Functional expression of a rapidly inactivating neuronal calcium channel

    DIVERSE types of calcium channels in vertebrate neurons are important in linking electrical activity to transmitter release, gene expression and modulation of membrane excitability1. Four classes of Ca2+ channels...

    Patrick T. Ellinor, Ji-Fang Zhang, Andrew D. Randall, Mei Zhou, Thomas L. Schwarz… in Nature (1993)

  3. No Access

    Article

    Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels

    VOLTAGE-GATED Ca2+ channels link changes in membrane potential to the delivery of Ca2+, a key second messenger for many cellular responses1. Ca2+ channels show selectivity for Ca2+ over more plentiful ions such a...

    Jian Yang, Patrick T. Elllnor, William A. Sather, JI-Fang Zhang, Richard W. Tsien in Nature (1993)

  4. No Access

    Article

    Structural determinants of the blockade of N-type calcium channels by a peptide neurotoxin

    NEUROTOXINS that selectively block Na+, K+ or Ca2+ channels have provided valuable information about the functional diversity of the voltage-gated channel superfamily1. For Ca2+ channels, a variety of toxins have...

    Patrick T. Ellinor, Ji-Fang Zhang, William A. Horne, Richard W. Tsien in Nature (1994)

  5. No Access

    Article

    Molecular determinants of voltage-dependent inactivation in calcium channels

    VOLTAGE-DEPENDENT Ca2+ channels respond to membrane depolarization by conformational changes that control channel opening and eventual closing by inactivation1–3. The kinetics of inactivation differ considerably ...

    Ji-Fang Zhang, Patrick T. Ellinor, Richard W. Aldrich, Richard W. Tsien in Nature (1994)

  6. No Access

    Article

    Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiPl

    Much of the predisposition to hereditary breast and ovarian cancer has been attributed to inherited defects in the BRCA1 tumour-suppressor gene1,2,3. The nuclear protein BRCA1 has the properties of a transcriptio...

    Kumaravel Somasundaram, Hongbing Zhang, Yi-**n Zeng, Yariv Houvras, Yi Peng… in Nature (1997)

  7. No Access

    Article

    Peptide bond formation by in vitro selected ribozymes

    An attractive solution to the problem of the origin of protein synthesis in an evolving ‘RNA world’ involves catalysis by nucleic acid without assistance from proteins1,2. Indeed, even the modern ribosome has bee...

    Biliang Zhang, Thomas R. Cech in Nature (1997)

  8. No Access

    Article

    Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin

    Vertebrates achieve internal homeostasis during infection or injury by balancing the activities of proinflammatory and anti-inflammatory pathways. Endotoxin (lipopolysaccharide), produced by all gram-negative ...

    Lyudmila V. Borovikova, Svetlana Ivanova, Minghuang Zhang, Huan Yang… in Nature (2000)

  9. Article

    Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity

    Recent studies of human immunodeficiency virus type 1 (HIV-1) infection in humans and of simian immunodeficiency virus (SIV) in rhesus monkeys have shown that resolution of the acute viral infection and contro...

    John W. Shiver, Tong-Ming Fu, Ling Chen, Danilo R. Casimiro, Mary-Ellen Davies… in Nature (2002)

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  10. No Access

    Article

    Remote electronic control of DNA hybridization through inductive coupling to an attached metal nanocrystal antenna

    Increasingly detailed structural1 and dynamic2,3 studies are highlighting the precision with which biomolecules execute often complex tasks at the molecular scale. The efficiency and versatility of these processe...

    Kimberly Hamad-Schifferli, John J. Schwartz, Aaron T. Santos, Shuguang Zhang… in Nature (2002)

  11. No Access

    Article

    Structure of a bacterial quorum-sensing transcription factor complexed with pheromone and DNA

    Many proteobacteria are able to monitor their population densities through the release of pheromones known as N-acylhomoserine lactones. At high population densities, these pheromones elicit diverse responses tha...

    Rong-guang Zhang, Katherine M. Pappas, Jennifer L. Brace, Paula C. Miller… in Nature (2002)

  12. No Access

    Article

    Chibby, a nuclear β-catenin-associated antagonist of the Wnt/Wingless pathway

    Inappropriate activation of downstream target genes by the oncoprotein β-catenin is implicated in development of numerous human cancers1,2. β-catenin and its fruitfly counterpart Armadillo act as a coactivator in...

    Ken-Ichi Takemaru, Shinji Yamaguchi, Young Sik Lee, Yang Zhang… in Nature (2003)

  13. No Access

    Article

    Ligand–receptor binding revealed by the TNF family member TALL-1

    The tumour necrosis factor (TNF) ligand TALL-1 and its cognate receptors, BCMA, TACI and BAFF-R, were recently identified as members of the TNF superfamily, which are essential factors contributing to B-cell m...

    Yingfang Liu, **a Hong, John Kappler, Ling Jiang, Rongguang Zhang, Liangguo Xu… in Nature (2003)

  14. No Access

    Article

    Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen

    The oncoprotein large tumour antigen (LTag) is encoded by the DNA tumour virus simian virus 40. LTag transforms cells and induces tumours in animals by altering the functions of tumour suppressors (including p...

    Dawei Li, Rui Zhao, Wayne Lilyestrom, Dahai Gai, Rongguang Zhang… in Nature (2003)

  15. Article

    Correction: Corrigendum: Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen

    Nature 423, 512–518 (2003). The name of A. J. was misspelt in the author list and should be Andrzej Joachimiak. Also, he is in the Biosciences Division of SBC (and not at the Advanced Photon Source, as publish...

    Dawei Li, Rui Zhao, Wayne Lilyestrom, Dahai Gai, Rongguang Zhang… in Nature (2003)

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  16. No Access

    Article

    Identification of the haematopoietic stem cell niche and control of the niche size

    Haematopoietic stem cells (HSCs) are a subset of bone marrow cells that are capable of self-renewal and of forming all types of blood cells (multi-potential)1. However, the HSC ‘niche’—the in vivo regulatory micr...

    Jiwang Zhang, Chao Niu, Ling Ye, Haiyang Huang, ** He, Wei-Gang Tong, Jason Ross… in Nature (2003)

  17. No Access

    Article

    Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5

    Mitogen-activated protein (MAP) kinases are essential regulators in immune responses1, and their activities are modulated by kinases and phosphatases. MAP kinase phosphatase (MKP) is a family of dual-specificity ...

    Yongliang Zhang, Joseph N. Blattman, Norman J. Kennedy, Julie Duong, Thang Nguyen… in Nature (2004)

  18. No Access

    Article

    Genetic evidence supports demic diffusion of Han culture

    The spread of culture and language in human populations is explained by two alternative models: the demic diffusion model, which involves mass movement of people; and the cultural diffusion model, which refers...

    Bo Wen, Hui Li, Daru Lu, **ufeng Song, Feng Zhang, Yungang He, Feng Li, Yang Gao… in Nature (2004)

  19. No Access

    Article

    A new self-pollination mechanism

    Pollen grains from most flowering plants are transported by wind or animals and deposited on the receptive surface of the stigma of a different individual, but self-pollination is also common. We have discover...

    Yingqiang Wang, Dianxiang Zhang, Susanne S. Renner, Zhongyi Chen in Nature (2004)

  20. No Access

    Article

    Crystal structure of the CorA Mg2+ transporter

    The transport mechanisms of most major biological ions have been determined in detail, apart from magnesium. CorA-type transporters are the main Mg2+ uptake system in most prokaryotes and in mitochondria. Now the...

    Vladimir V. Lunin, Elena Dobrovetsky, Galina Khutoreskaya, Rongguang Zhang… in Nature (2006)

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