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Virtual Screening Process: A Guide in Modern Drug Designing
Due to its capacity to drastically cut the cost and time necessary for experimental screening of compounds, virtual screening (VS) has grown to be a...
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Systems Biology Approach to Analyze Microarray Datasets for Identification of Disease-Causing Genes: Case Study of Oral Squamous Cell Carcinoma
The discovery of potential disease-causing genes can aid medical progress. The post-genomic era has made this a more difficult task. Modern...
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New Insights into Clinical Management for Sickle Cell Disease: Uncovering the Significant Pathways Affected by the Involvement of Sickle Cell Disease
One of the severe monogenic conditions with the highest prevalence in the globe is sickle cell disease. Although the significance of chronic anemia,...
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Big Data in Bioinformatics and Computational Biology: Basic Insights
The human genome was first sequenced in 1994. It took 10 years of cooperation between numerous international research organizations to reveal a...
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Identification of Mycoviruses by dsRNA Extraction
Mycoviruses exist in all major groups of fungi. With the continuous development of science and technology, the methods of studying viruses are...
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In Vivo Production of dsRNA Using Bacteriophage Ï•6 in Pseudomonas syringae Cit7 Cells
RNA interference (RNAi), also known as post-transcriptional gene silencing (PTGS), is one of the emerging genetic engineering techniques to...
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Application of dsRNA for Fungi Disease Management Sclerotinia sclerotiorum and Botrytis cinerea
Sclerotinia sclerotiorum and Botrytis cinerea are two closely related necrotrophic plant pathogenic fungi that have garnered significant attention...
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Detection of dsRNA with Fluorescence In Situ Hybridization (FISH)
Fluorescence in situ hybridization (FISH) is a powerful technique used for detecting and localizing specific nucleic acid sequences in cells or...
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Multiparametric Analysis of Apoptosis by Flow Cytometry
Flow cytometry remains the most widely used method for detecting and quantifying apoptosis and related forms of cell death in mammalian cells. The...
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Cytometry in High-Containment Laboratories
The emergence of new pathogens continues to fuel the need for advanced high-containment laboratories across the globe. Here we explore challenges and...
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Hi-M: A Multiplex Oligopaint FISH Method to Capture Chromatin Conformations In Situ and Accompanying Open-Source Acquisition Software
The simultaneous observation of three-dimensional (3D) chromatin structure and transcription in single cells is critical to understand how DNA is...
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hcHCR: High-Throughput Single-Cell Imaging of RNA in Human Primary Immune Cells
Functional genomics and chemical screens can identify and characterize novel cellular factors regulating signaling networks and chemical tools to...
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Computer-Aided Drug Discovery and Design: Recent Advances and Future Prospects
Computer-aided drug discovery and design involve the use of information technologies to identify and develop, on a rational ground, chemical...
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Molecular Dynamics and Other HPC Simulations for Drug Discovery
High performance computing (HPC) is taking an increasingly important place in drug discovery. It makes possible the simulation of complex biochemical...
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Hubs and Bottlenecks in Protein-Protein Interaction Networks
Protein-protein interaction networks (PPINs) represent the physical interactions among proteins in a cell. These interactions are critical in all...
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Inference of Dynamic Growth Regulatory Network in Cancer Using High-Throughput Transcriptomic Data
Growth is regulated by gene expression variation at different developmental stages of biological processes such as cell differentiation, disease...
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Systems Biology Approaches to Understanding COVID-19 Spread in the Population
In essence, the COVID-19 pandemic can be regarded as a systems biology problem, with the entire world as the system, and the human population as the...
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Optical Estimation of Bioelectric Patterns in Living Embryos
Fluorescent lifetime imaging (FLIM) is a powerful tool for visualizing physiological parameters in vivo. We present here a 3-dye strategy for map**...
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Identifying Key In Silico Knockout for Enhancement of Limonene Yield Through Dynamic Metabolic Modelling
Living cells display dynamic and complex behaviors. To understand their response and to infer novel insights not possible with traditional...
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Co-immunoprecipitation-Based Isolation of Double-Stranded RNA-Associated Protein Complexes in Nicotiana benthamiana
Double-stranded RNA (dsRNA) is associated with most viral infections, and is generated in host cells during viral replication. Viral RNA replication...