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Biomedicine
Bioinformatics
Systems Biology
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Processes Parallel Execution Using Grid Wizard Enterprise
The field of high-performance computing (HPC) has provided a wide array of strategies for supplying additional computing power to the goal of reducing the total “clock time” required to complete various comput...
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Enabling Public Data Sharing: Encouraging Scientific Discovery and Education
To promote scientific discovery and education, the federated Biomedical Informatics Research Network (BIRN) Data Repository (BDR) supports data storage, sharing, querying, and downloading for the biomedical co...
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System Biology of Gene Regulation
A famous joke story that exhibits the traditionally awkward alliance between theory and experiment and showing the differences between experimental biologists and theoretical modelers is when a University send...
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Methods of Information Geometry in Computational System Biology (Consistency between Chemical and Biological Evolution)
Interest in simulation of large-scale metabolic networks, species development, and genesis of various diseases requires new simulation techniques to accommodate the high complexity of realistic biological netw...
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Applications of Bioinformatics to Protein Structures: How Protein Structure and Bioinformatics Overlap
In this chapter, we will focus on the role of bioinformatics to analyze a protein after its protein structure has been determined. First, we present how to validate protein structures for quality assurance. Th...
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Brain Model of Text Animation as a Data Mining Strategy
Imagination is the critical point in develo** of realistic intelligence (AI) systems. One way to approach imagination would be simulation of its properties and operations. We developed two models “Brain Netw...
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Single Sign-On in a Grid Portal
Single Sign-On (SSO) is a practical requirement for software applications, which rely on distributed, networked services requiring authentication. SSO is as much a convenient feature for users as it is a secur...
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Management of Information in Distributed Biomedical Collaboratories
Organizing and annotating biomedical data in structured ways has gained much interest and focus in the last 30 years. Driven by decreases in digital storage costs and advances in genetics sequencing, imaging, ...
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Mediator Infrastructure for Information Integration and Semantic Data Integration Environment for Biomedical Research
This paper presents current progress in the development of semantic data integration environment which is a part of the Biomedical Informatics Research Network (BIRN; http://www.nbirn.net
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Current Computational Methods for Prioritizing Candidate Regulatory Polymorphisms
Discovery of DNA sequence variants responsible for human phenotypic variation is key to advances in molecular diagnostics and medicines. Historically, variants that alter the protein-coding sequence of genes h...
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Protein Structure Prediction Based on Sequence Similarity
The observation that similar protein sequences fold into similar three-dimensional structures provides a basis for the methods which predict structural features of a novel protein based on the similarity betwe...
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Knowledge Discovery via Machine Learning for Neurodegenerative Disease Researchers
Ever-increasing size of the biomedical literature makes more precise information retrieval and tap** into implicit knowledge in scientific literature a necessity. In this chapter, first, three new variants o...
