7 Result(s)
within
Biomedicine
Pharmacology/Toxicology
**n** Cao
Protocol
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Protocol
In Vivo cII, gpt, and Spi− Gene Mutation Assays in Transgenic Mice and Rats
Transgenic mutation assays are used to identify and characterize genotoxic hazards and for determining the mode of action for carcinogens. The three most popular transgenic mutational models are Big Blue® (rats o...
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Protocol
Array-Based Immunoassays with Rolling-Circle Amplification Detection
This chapter describes methods for the use of antibody microarrays with rolling-circle amplification (RCA). The methods are divided into three sections. The first section covers antibody preparation and microa...
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Protocol
Detection of Pig-a Mutant Erythrocytes in the Peripheral Blood of Rats and Mice
The endogenous X-linked phosphatidyl inositol glycan class A gene (Pig-a) can be used as a reporter of in vivo somatic cell mutation in rats and mice. Pig-a mutant cells are deficient in specific protein surface ...
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Protocol
Common Methods Used for the Discovery of Natural Anticancer Compounds
Carcinogenesis is a long-term, multifactorial, and multistep process. Dietary phytochemicals can play a significant role in cancer prevention. In this chapter, we describe common protocols to study the role of...
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Protocol
Evaluation of Protein–Ligand Docking by Cyscore
Protein–ligand docking is a powerful method in drug discovery. The reliability of docking can be quantified by RMSD between a docking structure and an experimentally determined one. However, most experimentall...
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Protocol
Detection of Pig-a Mutant Erythrocytes in the Peripheral Blood of Rats and Mice
The endogenous X-linked phosphatidyl inositol glycan class A gene (Pig-a) can be used as a reporter of in vivo somatic cell mutation in rats and mice. Pig-a mutant cells are deficient in specific protein surface ...
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Protocol
Protein–Ligand Blind Docking Using CB-Dock2
Protein–ligand blind docking is a widely used method for studying the binding sites and poses of ligands and receptors in pharmaceutical and biological research. Recently, our new blind docking server named CB...
