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Lead and calcium crosstalk tempted acrosome damage and hyperpolarization of spermatozoa: signaling and ultra-structural evidences
BackgroundExposure of humans and animals to heavy metals is increasing day-by-day; thus, lead even today remains of significant public health...
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Reinforcing effects of fentanyl analogs found in illicit drug markets
RationaleThe potent synthetic opioid fentanyl, and its analogs, continue to drive opioid-related overdoses. Although the pharmacology of fentanyl is...
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Navβ2 Intracellular Fragments Contribute to Aβ1-42-Induced Cognitive Impairment and Synaptic Deficit Through Transcriptional Suppression of BDNF
A pathological hallmark of Alzheimer’s disease (AD) is the region-specific accumulation of the amyloid-beta protein (Aβ), which triggers aberrant...
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Multicenter evaluation of mechanical thrombectomy for distal medium vessel occlusions with National Institute of Health Stroke Scale Scores ≥ 6 and ≤ 6
BackgroundWhile mechanical thrombectomy is considered standard of care for large vessel occlusions, scientific evidence to support treatment for...
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Incorporating slow NMDA-type receptors with nonlinear voltage-dependent magnesium block in a next generation neural mass model: derivation and dynamics
We derive a next generation neural mass model of a population of quadratic-integrate-and-fire neurons, with slow adaptation, and conductance-based...
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Current Topics Regarding the Function of the Medial Temporal Lobe Memory System
The first clear insight that the medial temporal lobe of the human brain was in fact a system of anatomically connected structures that were...
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From movement to motivation: a proposed framework to understand the antidepressant effect of exercise
Depression is the leading cause of disability worldwide, exerting a profound negative impact on quality of life in those who experience it....
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A skin-specific α-Synuclein seeding amplification assay for diagnosing Parkinson’s disease
The seeding amplification assay (SAA) has recently emerged as a valuable tool for detecting α-synuclein (αSyn) aggregates in various clinically...
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The use of Guyton’s approach to the control of cardiac output for clinical fluid management
Infusion of fluids is one of the most common medical acts when resuscitating critically ill patients. However, fluids most often are given without...
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Unraveling psilocybin’s therapeutic potential: behavioral and neuroplasticity insights in Wistar-Kyoto and Wistar male rat models of treatment-resistant depression
RationaleOur study aimed to unravel the unknown mechanisms behind the exceptional efficacy of Psilocybin (PSI) in treating treatment-resistant...
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“There is No Help:” Caregiver Perspectives on Service Needs for Adolescents and Adults with Profound Autism
The underrepresentation of individuals with profound autism (who require 24/7 access to care) in autism research has resulted in limited knowledge...
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Quantitative and calculated estimated blood loss in cesarean deliveries for twin and singleton pregnancies: a retrospective analysis
PurposeThis study retrospectively assessed blood loss during cesarean deliveries for twin and singleton pregnancies using two distinct methods,...
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New horizons for the role of selenium on cognitive function: advances and challenges
Cognitive deficits associated with oxidative stress and the dysfunction of the central nervous system are present in some neurodegenerative diseases,...
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The parasubthalamic nucleus refeeding ensemble delays feeding initiation and hastens water drinking
The parasubthalamic nucleus (PSTN) is activated by refeeding after food deprivation and several PSTN subpopulations have been shown to suppress...
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Context-dependent reduction in corticomuscular coupling for balance control in chronic stroke survivors
Balance control is an important indicator of mobility and independence in activities of daily living. How the functional coupling between the cortex...
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Evidence of bottom-up homeostatic modulation induced taVNS during emotional and Go/No-Go tasks
Bilateral transcutaneous auricular vagus nerve stimulation (taVNS) - a non-invasive neuromodulation technique – has been investigated as a safe and...
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Association between swallowing dynamics, tongue pressure and pulmonary function in patients with idiopathic pulmonary fibrosis
BackgroundSwallowing is a complex process that requires the coordination of muscles in the mouth, pharynx, larynx, and esophagus. Dysphagia occurs...
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Indicated Prevention for Children Screened in Routine Health Care: Effectiveness of a Social Skills Program on Social Anxiety and Depressive Symptoms
Social anxiety is common in childhood and potentially transitions into clinical disorders including depression. The present study aimed to examine...
