14 Result(s)
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Chapter and Conference Paper
Genetic and Molecular Biological Analysis of Protein-Protein Interactions in Coronavirus Assembly
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Chapter and Conference Paper
Histological Basis Of Mr/Optical Imaging Of Human Melanoma Mouse Xenografts Spanning A Range Of Metastatic Potentials
Predicting tumor aggressiveness will greatly facilitate cancer treatment. We have previously reported investigations utilizing various MR/optical imaging methods to differentiate human melanoma mouse xenograft...
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Chapter and Conference Paper
Lipoprotein Nanoplatform for Targeted Delivery of Diagnostic and Therapeutic Agents
Low-density lipoprotein (LDL) provides a highly versatile natural nanoplatform for delivery of optical and MRI contrast agents, photodynamic therapy agents and chemotherapeutic agents to normal and neoplastic ...
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Chapter and Conference Paper
31P-MRS Studies of Melanoma Xenografts with Different Metastatic Potential
Previously we reported that three imaging methods, dynamic contrast enhanced magnetic resonance imaging (DCE-MRI), T1ρ-MRI, and ultralow temperature NADH/flavoprotein fluorescence imaging (redox scanning), could ...
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Chapter and Conference Paper
What Is the Role of CCR3 in Choroidal Neovascularization?
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly in industrialized countries. The “wet” AMD, characterized by the development of choroidal neovacularization ...
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Chapter and Conference Paper
Regeneration of Cone Outer Segments Induced by CNTF
Secondary cone degeneration in the transgenic rats carrying the S334ter rhodopsin mutation (S334ter-3 rats) starts at the peak of rod degeneration (PD12) and progresses with age. An early sign of cone degenera...
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Chapter and Conference Paper
Can Mitochondrial Cytochrome Oxidase Mediate Hypoxic Vasodilation Via Nitric Oxide Metabolism?
The brain responds to hypoxia with an increase in cerebral blood flow (CBF). Many mechanisms have been proposed for this hypoxic vasodilation, but none has gained universal acceptance. Although there is some d...
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Chapter and Conference Paper
Modeling Hemoglobin Nitrite Reductase Activity as a Mechanism of Hypoxic Vasodilation?
The brain’s response to hypoxia is to increase cerebral blood flow (CBF). However, the molecular mechanism underpinning this phenomenon is controversial. We have developed a model to simulate brain blood flow ...
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Chapter and Conference Paper
Hemoglobin Effects on Nitric Oxide Mediated Hypoxic Vasodilation
The brain responds to hypoxia with an increase in cerebral blood flow (CBF). However, such an increase is generally believed to start only after the oxygen tension decreases to a certain threshold level. Altho...
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Chapter and Conference Paper
Analytical Expression for the NO Concentration Profile Following NONOate Decomposition in the Presence of Oxygen
We have derived an analytical expression for the time dependent NO concentration from NONOate donors in the presence of oxygen for the process of NO release from NO donors following autoxidation. This analytic...
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Chapter and Conference Paper
Efficient Protocol for the Identification of Hypoxic Cell Radiosensitisers
An evolution in radiotherapy practice is leading to greater use of stereotactic body radiotherapy (SBRT), raising the prospect of increased hypoxic cell radioresistance. New clinical interest in nitroimidazole...
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Chapter and Conference Paper
Studies of the Periciliary Membrane Complex in the Syrian Hamster Photoreceptor
Mutations in USH2A, ADGRV1, and WHRN genes cause Usher syndrome type 2 (USH2) and retinitis pigmentosa (RP). The proteins encoded by these genes form the periciliary membrane complex (PMC) in photoreceptors. Unli...
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Chapter and Conference Paper
Persistent Activation of STAT3 Pathway in the Retina Induced Vision Impairment and Retinal Degenerative Changes in Ageing Mice
Neurotrophic factors can promote the survival of degenerating retinal cells through the activation of STAT3 pathway. Thus, augmenting STAT3 activation in the retina has been proposed as potential therapy for r...
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Chapter and Conference Paper
Retinal Metabolic Profile on IMPG2 Deficiency Mice with Subretinal Lesions
The interphotoreceptor matrix (IPM) is the extracellular matrix between the photoreceptors and the retinal pigment epithelium (RPE). The IPM has two proteoglycans: the IPM proteoglycans 1 and 2 (IMPG1 and IMPG...
