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    Chapter

    Effects of metallothionein expression on development of drug resistance

    Metallothioneins (MTs) are low molecular weight metal-binding proteins with about 30% cysteine content [1]. MTs have been postulated to function in the protection against heavy metals, scavenging of free radic...

    Toby G. Rossman, Ekaterina I. Goncharova in Metallothionein IV (1999)

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    Chapter

    DNA Damage by Mercury Compounds: An Overview

    HgCl2-induced DNA damage has many similarities to those caused by X-rays; however, the single strand breaks induced by HgCl2 are not readily repaired, in contrast to those induced by X-rays. HgCl2 has also been s...

    Max Costa, Nelwyn T. Christie, Orazio Cantoni… in Advances in Mercury Toxicology (1991)

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    Chapter

    Use of the Microscreen Assay for Airborne Particulate Organic Matter

    The value of short-term in vitro assays to screen for potential human mutagens and carcinogens is well established. The most extensively validated short-term assay is the Ames test (Ames etal., 1975). This assay ...

    Toby G. Rossman, LeRoy W. Meyer… in Short-Term Bioassays in the Analysis of Co… (1985)