13 Result(s)
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Chapter
Advances in Alternate, Non-PAP, Non-surgical Therapies in the Treatment of Obstructive Sleep Apnea
Positive pressure therapy (PAP) is widely recognized as the gold standard treatment for OSA. Long-term adherence to PAP therapy, on the other hand, is typically low, ranging from 40 to 60%. Lifestyle modificat...
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Chapter
Central Sleep Apnea: Advances in the Last Decade
Central sleep apnea (CSA) is characterized by recurrent apneic episodes with absent respiratory effort. This is not a common clinical condition like obstructive sleep apnea. Central sleep apnea is diagnosed wh...
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Chapter
Wearable Technologies/Consumer Sleep Technologies in Relation to Sleep Disorders Developments in the Last Decade
Wearable devices [consumer sleep technologies (CSTs)] have disrupted sleep disorders management in the world today. In the USA, sleep disorders are managed in sleep disorders centers, usually accredited by AAS...
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Chapter
Melatonin as a Chronobiotic and Cytoprotector in Healthy Aging
A circadian alteration, as shown by a disturbed sleep and a low-degree inflammation, i.e., “inflammaging,” are two common disruptions oftenly seen in aging. Their aggravation contributes substantially to the e...
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Current Clinical Perspective of Adult Obstructive Sleep Apnea: Symptomatology, Clinical Features, and Different Phenotypes
The incidence and prevalence of obstructive sleep apnea (OSA) continue to rise in the United States and the world. The prevalence of OSA is conservatively estimated to be 3% among women and 10% among men 30 to...
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Traffic Safety in Sleep Deprivation, Sleepiness, and Sleep Disorders
Every year, a substantial number of people are killed or injured due to motor vehicle accidents (MVAs). A large number of these collisions are caused by driving errors. Vehicles travel at fast speeds, necessit...
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Pineal Gland Physiology and Aging-Related Alterations in the Circadian Timing System
For the last few decades, multiple research groups have studied the various processes, mechanisms, and regulations that can be manipulated to slow down the aging process in both animals and humans. Melatonin, ...
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Chapter
Impact of REM Sleep on Sleep Disorders: Current Perspectives
Sleep is a complex process characterized by different stages, including rapid eye movement (REM) and non-rapid eye movement (NREM) sleep. Throughout the night, the body cycles through these stages, with REM sl...
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The Effects of Melanin-Concentrating Hormone on Neurotransmitter Systems Involved in the Generation and Maintenance of Wakefulness
Within the central nervous system (CNS), melanin-concentrating hormone (MCH) participates in a number of functions including sleep-wake behavior. In this respect, MCHergic neurons project widely throughout the...
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The Involvement of 5-HT2A Receptor in the Regulation of Sleep and Wakefulness, and the Potential Therapeutic Use of Selective 5-HT2A Receptor Antagonists and Inverse Agonists for the Treatment of an Insomnia Disorder
Several agents have been shown to improve sleep induction and/or maintenance in patients with primary or comorbid insomnia. These include benzodiazepine and non-benzodiazepine receptor allosteric modulators, m...
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Chapter
Sodium Oxybate (Xyrem®): A New and Effective Treatment for Narcolepsy with Cataplexy
Sodium oxybate (SXB; Xyrem®) is the sodium salt of gamma hydroxybutyric acid (GHB). SXB has been approved in the United States for the treatment of cataplexy and excessive daytime sleepiness (EDS) in patients wit...
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Chapter
Circadian control by serotonin and melatonin receptors: Clinical relevance
This chapter reviews the role of the different serotonin receptors located in the circadian apparatus and their possible clinical implications for the activity of antidepressants. The central oscillator locate...
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Chapter
Circadian Organization of the Immune Response
Organisms populating the Earth are under the steady influence of daily and seasonal changes resulting from the planet's rotation and orbit around the sun. This periodic pattern is most prominently manifested b...
