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Chapter
Kinins in the Heart
Kinins are polypeptides that contain the sequence of the nonapeptide, bradykinin, in their structure. In mammals, the main kinins are bradykinin and lysine-bradykinin. They are generated by a group of enzymes ...
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Chapter
The molecular biology of the kallikrein-kinin system
There are numerous indications that the kallikrein-kinin system is underexpressed in various forms of hypertension: for example, urinary kallikrein excretion is decreased in human essential hypertension and in...
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Chapter
Kininogenase from Rat Vascular Tissue
A kininogenase resembling glandular kallikrein ws partially purified from vascular tissue and characterized. Saline perfused rat tail arteries and veins were homogenized in 0.25 M sucrose containing 10 mM Tris...
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Chapter
Release of Kallikrein and Tonin from the Rat Submandibular Gland
The interaction of neurotransmitters and hormones with specific receptors on the plasma membranes of cells results in enzyme secretion from exocrine glands. However, the effects of agonists on the release of k...
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Chapter
Kallikrein and Kinins Independently Stimulate Renin Release from Isolated Rat Glomeruli
We studied the interaction between kallikrein, kinins, and renin release in isolated rat renal glomeruli and their attendant arterioles. Purified hog kallikrein (170 mEU/ml) significantly stimulated renin rele...
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Chapter
Effect of Sodium Restriction and Corticosteroids on Glandular Kallikrein in Plasma and in the Submandibular Gland
We investigated whether sodium restriction or mineralocorticoid influence the release of submandibulary kallikrein into the blood and/or the concentration of kallikrein in glandular tissue. For this we measure...
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Chapter
The Glandular Kallikrein-Kinin System in Hypertension
Kallikreins are enzymes that release kinins, potent vasodilator peptides from plasma substrates called kininogens. In the microdissected nephron, prekallikrein and kailikrein are localized in the granular part...