6 Result(s)
within
Chapter
Mervyn Singer
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Chapter
Airway and Ventilation Management
Patients requiring intubation and mechanical ventilation due to underlying neurological disease usually have a need for prolonged weaning. Such patients include those with central disturbances of respiratory r...
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Chapter
Mitochondrial Function
While markers of global oxygen delivery are readily measurable at the bedside, the crucial question is whether this is sufficient for the cells to produce adequate energy substrate (ATP) to enable metabolism t...
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Oxygen and Oxidative Stress
Oxygen is a structural and functional compound essential to life. Evoking the toxicity of this molecule could seem inappropriate or even provocative. After its discovery by Priestley in 1774, Lavoisier named i...
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Tracking changes in cardiac output: methodological considerations for the validation of monitoring devices
Background: Until now, tools for continuous cardiac output (CO) monitoring have been validated as if they were tools for snapshot measurements. Most authors have compared variations in cardiac outp...
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Inhibition of Mitochondrial Respiration During Early Stage Sepsis
It is known that nitric oxide (NO) is produced in response to a septic insult such as bacterial invasion and that overproduction of NO can have serious debilitating consequences. The mechanism by which NO caus...
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Chapter
Reactive Oxygen Species in Clinical Practice
Reactive oxygen species (ROSs) are oxidants produced in both health and disease by various processes, for example, from the phagocytic respiratory burst, during mitochondrial aerobic respiration, and as a by-p...
