20 Result(s)
within
Chapter
Makoto Suzuki
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Chapter
Molecular Imaging of PD-1 Unveils Unknown Characteristics of PD-1 Itself by Visualizing “PD-1 Microclusters”
Programmed cell death-1 (PD-1) is one of the most famous coinhibitory receptors that are expressed on effector T cells to regulate their function. The PD-1 ligands, PD-L1 and PD-L2, are expressed by various ce...
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Chapter
Novel Intermolecular Surface Force Unveils the Driving Force of the Actomyosin System
In this chapter, we discuss the role of water in actomyosin-force generation. We have been investigating the hydration properties of ions, organic molecules, and proteins. These studies revealed that actin fil...
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Chapter
Spatial Distribution of Ionic Hydration Energy and Hyper-Mobile Water
In this chapter, we provide the following two topics.
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We carry out DRS measurements for divalent metal chloride and trivalent metal chl...
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Chapter and Conference Paper
A Study on Structural Behavior of Reinforced Concrete Walls Exposed to Hydrocarbon Fire Under Vertical Load
In order to investigate the structural behavior of a reinforced concrete wall exposed to a hydrocarbon fire while under a vertical load, fire-resistance tests and numerical analyses are carried out on small-sc...
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Chapter and Conference Paper
The Support System for a Visual Impaired Person Using Laser Eyewear
We construct a system for a visually impaired person. On our system, an image is input by a camera, is transformed by an image conversion system, and is provided to the visually impaired person by an eyewear l...
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Chapter
The Molecular Mechanism of Multifunctional Mechano-Gated Channel TRPV4
Transient receptor potential vanilloid 4 (TRPV4) is a member of the TRP family of channels. It contains 6 transmembrane domains and was first identified as a hypoosmolality-activated Ca2+ permeable channel. TRPV4...
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Chapter
TRP Channels and Mechanical Signals
Transient receptor potential (TRP) channels are a unique cellular mechanism converting a wide variety of signals, including mechanical stress, to cation flow. The protein was first discovered in studies that e...
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Chapter and Conference Paper
Possible role of Ccn family members during osteoblast differentiation
CCN family members share common structural characteristics, and it has been suggested that they might have similar or redundant functions. Actually, different CCN proteins were reported to share some biologica...
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Chapter
Okinawa: A Naturally Calorie Restricted Population
The people of Okinawa prefecture (southernmost island chain of Japan) are among the longest lived in the world, in terms of average life expectancy at birth, life expectancy at older ages, centenarian prevalen...
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Chapter
A Benefit from the Modern Portfolio Theory for Japanese Pension Investment
There were two paradigm shifts in Japanese pension investment. One was the investment deregulation in 1997 and another was an introduction and development of the modern portfolio theory. Until late 1980s, the ...
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Chapter
Mechanosensitive Channel TRPV4
The transient receptor potential vanilloid 4 (TRPV4), a member of the TRP family that has a 6-transmembrane (TM) segment, was first identified as a hypoosmolality-activated Ca2+ permeable channel. The mechanism o...
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Chapter and Conference Paper
Molecular Breeding of Low-Phytic-Acid Grains in Rice by Using the Promoter of 18 kDa Oleosin
In most plant seeds, phosphorus is stored primarily as myo-inositol 1,2,3,4,5,6-hexakisphosphate (InsP6; phytic acid). Monogastric animals are unable to utilize phytic acid phosphorus efficiently because they lac...
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Chapter
Motor Protein Mechanism Coupled with Hydrophobic Hydration/Dehydration Cycle
Muscle protein myosin is one of the most attractive mechanochemical enzymes which convert chemical energy into mechanical work. Figure 13.1 shows a schematic image of actin-myosin interaction producing a slidi...
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Chapter
Molecular Cloning of a New Aquaporin Superfamily in Mammals
Currently, aquaporins (AQPs) are divided into two subfamilies: AQP1 group and AQP3 group. AQP1 group is water-selective AQP and has 6 members in mammals: AQPO, AQP1, AQP2, AQP4, AQP5, AQP6. They share similar ...
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Chapter and Conference Paper
A newly developed stereotactic robot with detachable drive for neurosurgery
This paper describes the development of a needle insertion manipulator for stereotactic neurosurgery. This robot fulfils the requirements of having both a safe mechanical design and the capacity for being ster...
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Chapter and Conference Paper
Quantitative Vascular Shape Analysis for 3D MR-Angiography Using Mathematical Morphology
Beyond visualization of 3D MR-Angiography, further analysis has been carried out to obtain vascular shape in an anatomically-relevant generalized cone expression, which is suitable for the purpose of surgical ...
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Chapter and Conference Paper
Computer Aided Surgery (CAS) System for Stereotactic Neurosurgery
Computer Aided Surgery (CAS) system for stereotactic neurosurgery has been developed by means of robotics and software technology. In this paper, we describe design concepts and features of our system which co...
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Chapter and Conference Paper
Direct Prevention Against Progressive 201TL Perfusion Defects by Captopril Treatment in Patients with Mild to Moderate Heart Failure
Angiotensin-converting enzyme inhibitors are effective for the treatment of patients with severe congestive heart failure and have been shown to alleviate symptoms and improve prognosis (1,2). Furthermore, in ...
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Chapter and Conference Paper
Does Hypertrophic Cardiomyopathy Change into Dilated Cardiomyopathy-Like Features?
Hypertrophic cardiomyopathy sometimes progresses to dilated cardiomyopathy-like features [1–5]. The etiology of the progression remains to be determined. Recently, we reported a patient with hypertrophic cardi...
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Chapter
Amphoteric Polyvinyl Alcohol Hydrogel and Electrohydrodynamic Control Method for Artificial Muscles
Since Kuhn and Katchalsky et al.1 first demonstrated artificial muscle in 1950, various mechanochemical materials have been presented.2 From the view point of mechanical engineering, great hopes are set on these ...
