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Chapter
Structure and Mechanism of Plant DNA Methyltransferases
DNA methylation is an important epigenetic mark conserved in eukaryotes from fungi to animals and plants, where it plays a crucial role in regulating gene expression and transposon silencing. Once the methylat...
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Chapter and Conference Paper
Taurine Increases Spermatozoa Quality and Function in Asthenospermia Rats Impaired by Ornidazole
Asthenospermia has been considered as one of the crucial causes of male infertility, which was closely related to epididymal dysfunction. Lots of documents have revealed that taurine palys an important role in...
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Chapter
Glutaric Aciduria Type 1 and Acute Renal Failure: Case Report and Suggested Pathomechanisms
Glutaric aciduria type 1 (GA1) is caused by deficiency of the mitochondrial matrix enzyme glutaryl-CoA dehydrogenase (GCDH), leading to accumulation of glutaric acid (GA) and 3-hydroxyglutaric acid (3OHGA) in ...
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Chapter
Epigenetic Switching in the Human Fungal Pathogen Candida albicans
The human fungal pathogen Candida albicans can grow in a number of distinct morphologies: yeast (including white, gray, opaque, and GUT forms), hyphae, and pseudohyphae. White and opaque cells are two heritable c...
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Chapter
Network Analysis and Fine-Map** GWAS Loci to Identify Genes and Functional Variants Involved in the Development of Dupuytren Disease
The first genome-wide association study (GWAS) in Dupuytren disease (DD) has successfully identified nine genomic regions that harbor genetic variants contributing to the genetics of this disease. In GWASs com...
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Chapter
News on Clinical Details and Treatment in PGM1-CDG
Phosphoglucomutase 1 deficiency has recently been reported as a novel disease that belongs to two different classes of metabolic disorders, congenital disorders of glycosylation (CDG) and glycogen storage dise...
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Chapter
Involvement of Non-coding RNAs in the Signaling Pathways of Colorectal Cancer
Colorectal cancer (CRC) is one of the most common diagnosed cancers worldwide. The metastasis and development of resistance to anti-cancer treatment are major challenges in the treatment of CRC. Understanding ...
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Chapter
Influence of PAH Genotype on Sapropterin Response in PKU: Results of a Single-Center Cohort Study
Objective: Identifying phenylalanine hydroxylase (PAH) mutations associated with sapropterin response in phenylketonuria (PKU) would be an advantageous means to determine clinical benefit to saprop...
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Chapter
Analysis of Metagenomic Data
In this chapter, we first briefly introduce the background of next-generation sequencing metagenomics, including the special properties in this research field and the challenges for statistical analysis. A met...
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Chapter
Synaptic Plasticity in the Pathophysiology and Treatment of Bipolar Disorder
Emerging evidence suggests that synaptic plasticity is intimately involved in the pathophysiology and treatment of bipolar disorder (BPD). Under certain conditions, over-strengthened and/or weakened synapses a...
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Chapter
RNA Interference Expression Vectors Based on miRNAs and RNA Splicing
RNA interference (RNAi) has emerged as a powerful tool in basic research and therapeutics by silencing the expression of specific target genes. RNAi occurs naturally within cells to regulate gene expression at...
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Chapter
Telomerase Mutations and Premature Ageing in Humans
Dyskeratosis congenita (DC) is a rare inherited bone marrow failure syndrome which gets its name from the classic diagnostic triad of abnormal skin pigmentation, nail dystrophy, and leukoplakia. Most DC patien...
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Chapter
Hybrid Peptide-Polyketide Natural Products: Biosynthesis and Prospects Towards Engineering Novel Molecules
Polyketides and nonribosomal peptides are two groups of secondary metabolites found in many microorganisms and plants. Biosynthesis and genetic engineering of polyketide and nonribosomal peptide natural produc...
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Chapter
The Production and Delivery of Therapeutic Peptides in Plants
There is a wide range of naturally-occurring peptides with immunophysiological function of particular relevance to the intestinal health and development of mammals. Our goal is to produce and deliver therapeut...
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Chapter
Edible Vaccines in Plants for Livestock Pathogens
Edible vaccines derived from plants offer clear advantages to the livestock industry with respect to cost and ease of delivery. From a consumer perspective, the widespread adoption by the industry of efficient...
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Chapter
The Phylogenetic Origin of Antigen-Specific Receptors
The adaptive immune system of gnathostomes, vertebrates with jaws, is characterized by somatic rearrangement of gene segments to generate genes encoding dimeric antigen-specific receptors (Ig; T-cell receptor,...
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Chapter
Genesis and Progression of Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
MALT lymphomas typically arise in extranodal tissues, such as the stomach, which are normally devoid of lymphoid tissue but which have acquired MALT as the result of a chronic inflammatory disorder. In the sto...
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Chapter
Sodium Induced Regulation of Angiotensin Receptor 1A And 1B in Rat Kidney
Two AT1 receptor subtypes, AT1A and AT1B, have been cloned and sequenced in the rat.15 Although AT1A and AT1B share a high degree (96%) of amino acid homology,3, 5 they may be functionally different. In studies o...
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Chapter
Detection of Genetic Imbalances in Tumor Genomes by Fluorescence in situ Hybridization with Tumor Genomic DNA and Subregional DNA Probes
During the last decade strong evidence has been accumulated for a causal relationship between specific genetic alterations and the abnormal differentiation state and growth behaviour of malignant cells. Such a...
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Chapter and Conference Paper
Polymorphism of HLA-DRB3 and DRB4 Genes Detected by RFLPs
All the characterized human HLA class II genes are encoded within the major histocompatibility complex (MHC) on the short arm of chromosome six. Among the five subregions of the class II region, HLA-DR is uniq...