10 Result(s)
within
English
Medicine & Public Health
Human Genetics
Li**g Du
Chapter
-
Chapter
Network Analysis and Fine-Map** GWAS Loci to Identify Genes and Functional Variants Involved in the Development of Dupuytren Disease
The first genome-wide association study (GWAS) in Dupuytren disease (DD) has successfully identified nine genomic regions that harbor genetic variants contributing to the genetics of this disease. In GWASs com...
-
Chapter
Genesis and Progression of Gastric Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma
MALT lymphomas typically arise in extranodal tissues, such as the stomach, which are normally devoid of lymphoid tissue but which have acquired MALT as the result of a chronic inflammatory disorder. In the sto...
-
Chapter and Conference Paper
Polymorphism of HLA-DRB3 and DRB4 Genes Detected by RFLPs
All the characterized human HLA class II genes are encoded within the major histocompatibility complex (MHC) on the short arm of chromosome six. Among the five subregions of the class II region, HLA-DR is uniq...
-
Chapter and Conference Paper
The Generation of Class II Polymorphism by Recombination
One of the most striking features of the HLA gene products is their high degree of polymorphism. The HLA class II polymorphism varies from locus to locus, e.g. at present there are 18 serological defined antig...
-
Chapter and Conference Paper
Evolutions of the Immune System
Determining the relative importance of the elements of the immune sytem is a major task to which comparative studies may help first in pointing to key elements and second in suggesting their phylogenetic origi...
-
Chapter and Conference Paper
T Cell Differentiation in Lower Vertebrates
With all the recent advances in the study of T cell differentiation in mice, it is reasonable to question whether anything can be fetched from the examination of this problem in lower vertebrates. One obvious ...
-
Chapter and Conference Paper
Segregation of DQ and DR: “Exceptions to the Rule”
The strong associations of DQw1 with DR1, 2, w6, and w10, of DQw2 with DR3 and 7, and of DQw3 with DR4 and 5 have been defined in studies with cells of Caucasoid origin. The use of monoclonal antibodies and ca...
-
Chapter and Conference Paper
Antigen Report: HLA-Bw67
During the Sixth and Seventh Workshop, new HLA-B specificities (SN-2, BF, Te90) intermediate between B16 and Bw22 were described [1, 2]. During the Eighth Workshop, these specificities were coded as 8w57: the ...
-
Chapter and Conference Paper
Antigen Report: HLA-Cw3
Cw3 was first described by means of two sera, UPS from Copenhagen and Sa-50 from Gothenburg [9]. This antigen was confirmed as belonging to the third HLA series at the 1975 Workshop [8], where it was called Cw...
-
Chapter and Conference Paper
Antigen Report: HLA-Aw43
In 1972, the occurrence of apparent triplets associated with HLA-A10 and A29 in the Khoisan populations of Namibia was reported [1]. In 1975 [6], an HLA-A10/A29 allele was defined in terms of the Fifth Interna...
