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Chapter
Transforming Growth Factor α: A Potential Autocrine Growth Regulator in Prostatic Carcinoma
Since the classical observation of Huggins and Hodges in 1941 [1], the efficacy of androgen-ablative therapy has been well established in the management of patients with advanced prostate cancer. However, this...
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Chapter
Role of Androgens and Extracellular Matrix in the Growth and Differentiation of Benign and Malignant Prostate Epithelial Cells
Normal tissues maintain a balance between growth and differentiation. During normal adult life, the prostatic epithelium undergoes little net growth but synthesizes and secretes proteins such as prostate speci...
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Chapter
The Impact of Androgen, Extracellular Matrix, and Stroma Upon Proliferation and Differentiation of Benign and Malignant Prostate Epithelial Cells
Mesenchymal-epithelial interactions are thought to playa strategic role in androgen-induced regulation of prostate epithelial cell growth and differentiation. A more thorough understanding of this process has ...
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Chapter
Cancer of the Bladder